≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Defensamide (MHP) Defensamide (MHP) is an activator of sphingosine kinase (SPHK1) . It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production.
Targets
SPHK1
In vitro
Treatment with MHP directly activates SPHK1 and increases cellular S1P content in normal cultured human keratinocytes. MHP also stimulates CAMP production and enhances epidermal antimicrobial defense via the recently identified S1P-dependent mechanism. Defensamide (MHP) treatment also activates NF-κB which is assessed by nuclear translocation of NF-κB.
| ALogP | 2.914 |
|---|---|
| hba_count | 3 |
| HBD-Zahl | 2 |
| Rotationsfähige Bindung | 9 |
| Pubchem Sid | 504771432 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504771432 |
| Kanonisches Lächeln | CCCCCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)OC |
| IUPAC Name | methyl (2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoate |
| InChIKey | GBTVWZMJUZJPBU-AWEZNQCLSA-N |
| INCHI | 1S/C16H23NO4/c1-3-4-5-6-15(19)17-14(16(20)21-2)11-12-7-9-13(18)10-8-12/h7-10,14,18H,3-6,11H2,1-2H3,(H,17,19)/t14-/m0/s1 |
| Isomere SMILES | CCCCCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)OC |
| Molekulargewicht | 293.36 |
| Reaxy-Rn | 48134938 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=48134938&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Klasse | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives - Alpha amino acids and derivatives |
| Direct Parent | Tyrosine and derivatives |
| Alternative Parents | Phenylalanine and derivatives N-acyl-alpha amino acids and derivatives Alpha amino acid esters Amphetamines and derivatives Fatty acid esters 1-hydroxy-2-unsubstituted benzenoids N-acyl amines Methyl esters Secondary carboxylic acid amides Monocarboxylic acids and derivatives Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Tyrosine or derivatives - Phenylalanine or derivatives - Alpha-amino acid ester - N-acyl-alpha amino acid or derivatives - Amphetamine or derivatives - 1-hydroxy-2-unsubstituted benzenoid - Fatty acid ester - Phenol - Benzenoid - N-acyl-amine - Fatty amide - Fatty acyl - Monocyclic benzene moiety - Methyl ester - Secondary carboxylic acid amide - Carboxylic acid ester - Carboxamide group - Monocarboxylic acid or derivatives - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organic oxygen compound - Aromatic homomonocyclic compound |
| Beschreibung | This compound belongs to the class of organic compounds known as tyrosine and derivatives. These are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Datum | Artikel |
|---|---|---|---|
 G2215317 | Certificate of Analysis | Apr 03, 2025 | D413494 |
| G2215318 | Certificate of Analysis | Apr 03, 2025 | D413494 |
| G2215319 | Certificate of Analysis | Apr 03, 2025 | D413494 |
| G2215320 | Certificate of Analysis | Apr 03, 2025 | D413494 |
| G2215355 | Certificate of Analysis | Apr 03, 2025 | D413494 |
| Löslichkeit | Solubility (25°C) In vitro DMSO: 100 mg/mL (340.87 mM); Water: 100 mg/mL (340.87 mM); Ethanol: Insoluble; |
|---|---|
| DMSO (mg/ml) Maximale Löslichkeit | 100 |
| DMSO (mM) Maximale Löslichkeit | 340.878101990728 |
| Wasser (mg/ml) Maximale Löslichkeit | 100 |
| Wasser (mM) Maximale Löslichkeit | 340.878101990728 |
| Molekulargewicht | 293.360 g/mol |
| XLogP3 | 2.200 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 9 |
| Exact Mass | 293.163 Da |
| Monoisotopic Mass | 293.163 Da |
| Topological Polar Surface Area | 75.600 Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 324.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
