Deflazacort - Moligand™, 10mM in DMSO , CAS No.14484-47-0

CAS: 14484-47-0 Cat. No.: D408396 Summenformel: C₂₅H₃₁NO₆ Molekulargewicht: 441.52 EG-Nummer: 238-483-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

MDL 458 | 5'H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2'-methyl-, (11β,16β)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Deflazacort Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
In vitro

In vivo

Deflazacort results in a significant and equal decrease of thymus weight, indicating a marked reduction in total immunogenic tissue in rats. Deflazacort reduces thymus weight and Daily weight gain in rats. Deflazacort lowers liver IFG-I and GHR mRNA in rats. Deflazacort (DFC) is a heterocyclic glucocorticoid with anti-inflammatory activity but with decreased side effects. Deflazacort and [3H]dexamethasone (DEX) similarly induce in vivo ornithine decarboxylase activity in hippocampus and liver, although body weight loss after chronic treatment is significantly less for DFC. Deflazacort induces dose-dependent decreases in osteocalcin (OC) plasma production rate (PPR). Deflazacort and prednisolone increase both postabsorptive plasma glucose and plasma calcium levels in sheep, but there are no significant differences between their effects. Deflazacort, especially combined with L-arginine, spares quadriceps muscle from injury-induced regeneration (myf5 expression) compared with placebo treatment, despite an increase in membrane permeability immediately after exercise. Deflazacort alone prevents the typical progressive loss of function (measured as voluntary distance run over 24 hours) that is observed 3 months later in placebo-treated mice. Deflazacort causes a less significant alteration in the pattern of GH secretion and does not negatively affect the overall amount of GH secreted.
Cell Data

cell lines：Colon cancer cell lines DLD-1, LoVo, HCT15, and Colo205

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

MDL 458 | 5'H-Pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2'-methyl-, (11β,16β)-

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

AGONIST

Produkteigenschaften

ALogP

2

Namen und Kennungen

Isomere SMILES

CC1=N[C@@]2([C@H](O1)C[C@@H]3[C@@]2(C[C@@H]([C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)O)C)C(=O)COC(=O)C

WGK Deutschland

3

Alternative CAS-Nummer

14484-47-0

MeSH-Eintrag

Calcort;deflazacort;Dezacor;Emflaza;Zamene

Molekulargewicht

441.52

Reaxy-Rn

37936925

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37936925&ln=