Dehydroevodiamine hydrochloride - ≥99% , CAS No.111664-82-5

CAS: 111664-82-5 Cat. No.: D413069 Summenformel: C₁₉H₁₅N₃O.HCl Molekulargewicht: 337.8 EG-Nummer: 112-522-7

GRADE & PURITY ≥99%

Synonyms

Indolo[2',​3':3,​4]​pyrido[2,​1-​b]​quinazolin-​5(7H)​-​one,8,​14-​dihydro-​14-​methyl-​,hydrochloride (1:1)

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Information

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibitAChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Targets

AChE

In vitro

Dehydroevodiamine·HCl (DHED) treatment significantly recovers the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. It decreases intracellular calcium levels in primary cortical neurons.

In vivo

Dehydroevodiamine·HCl (DHED) can improve stress-induced memory impairments and depression-like behaviors. DHED significantly improves learning and memory in the Aβ_1-42-infused rat model. Antiamnestic effects of DHED occur through an improvement of learning and memory and an inhibition of neuronal dysfunction in a scopolamine-induced amnesic rat model. Furthermore, Dehydroevodiamine·HCl (DHED) has hypotensive and neuroprotective effects and modulates nitric oxide production.

Cell Research(from reference)

Cell lines：primary cortical neurons 

Concentrations：0.5 and 1 µM 

Incubation Time：4 h 

Specifications

Synonyme

Indolo[2',​3':3,​4]​pyrido[2,​1-​b]​quinazolin-​5(7H)​-​one,8,​14-​dihydro-​14-​methyl-​,hydrochloride (1:1)

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Storage

Protected from light,Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥99%

Produkteigenschaften

• ALogP: 2.891
• hba_count: 2

Namen und Kennungen

• Kanonisches Lächeln: Cl.CN1C2=CC=CC=C2C(=O)N3CCC4=C5C=CC=CC5=NC4=C13
• Molekulargewicht: 337.8
• Reaxy-Rn: 5326818
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5326818&ln=

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 37 mg/mL (109.53 mM)
• Empfindlichkeit: light sensitive;Moisture sensitive
• DMSO (mg/ml) Maximale Löslichkeit: 37
• DMSO (mM) Maximale Löslichkeit: 109.5322676