Dehydroevodiamine hydrochloride - ≥99% , CAS No.111664-82-5

CAS: 111664-82-5 Cat. No.: D413069 Molecular Weight: 337.8 EC Number: 112-522-7

GRADE & PURITY ≥99%

Synonyms

Indolo[2',​3':3,​4]​pyrido[2,​1-​b]​quinazolin-​5(7H)​-​one,8,​14-​dihydro-​14-​methyl-​,hydrochloride (1:1)

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibitAChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Targets

AChE

In vitro

Dehydroevodiamine·HCl (DHED) treatment significantly recovers the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. It decreases intracellular calcium levels in primary cortical neurons.

In vivo

Dehydroevodiamine·HCl (DHED) can improve stress-induced memory impairments and depression-like behaviors. DHED significantly improves learning and memory in the Aβ_1-42-infused rat model. Antiamnestic effects of DHED occur through an improvement of learning and memory and an inhibition of neuronal dysfunction in a scopolamine-induced amnesic rat model. Furthermore, Dehydroevodiamine·HCl (DHED) has hypotensive and neuroprotective effects and modulates nitric oxide production.

Cell Research(from reference)

Cell lines：primary cortical neurons 

Concentrations：0.5 and 1 µM 

Incubation Time：4 h 

Specifications

Synonyms

Indolo[2', ​3':3, ​4]​pyrido[2, ​1-​b]​quinazolin-​5(7H)​-​one, 8, ​14-​dihydro-​14-​methyl-​, hydrochloride (1:1)

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Product Properties

• ALogP: 2.891
• hba_count: 2

Names and Identifiers

• Canonical Smiles: Cl.CN1C2=CC=CC=C2C(=O)N3CCC4=C5C=CC=CC5=NC4=C13
• Molecular Weight: 337.8
• Reaxy-Rn: 5326818
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5326818&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 37 mg/mL (109.53 mM)
• Sensitivity: light sensitive;Moisture sensitive
• DMSO(mg / mL) Max Solubility: 37
• DMSO(mM) Max Solubility: 109.5322676