Dehydroevodiamine hydrochloride - 10mM in DMSO , CAS No.111664-82-5

CAS: 111664-82-5 Cat. No.: D420627 Summenformel: C₁₉H₁₅N₃O.HCl Molekulargewicht: 337.8 EG-Nummer: 112-522-7

GRADE & PURITY 10mM in DMSO

Synonyms

Indolo[2',​3':3,​4]​pyrido[2,​1-​b]​quinazolin-​5(7H)​-​one,8,​14-​dihydro-​14-​methyl-​,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibitAChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Targets

AChE

In vitro

Dehydroevodiamine·HCl (DHED) treatment significantly recovers the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. It decreases intracellular calcium levels in primary cortical neurons.

In vivo

Dehydroevodiamine·HCl (DHED) can improve stress-induced memory impairments and depression-like behaviors. DHED significantly improves learning and memory in the Aβ_1-42-infused rat model. Antiamnestic effects of DHED occur through an improvement of learning and memory and an inhibition of neuronal dysfunction in a scopolamine-induced amnesic rat model. Furthermore, Dehydroevodiamine·HCl (DHED) has hypotensive and neuroprotective effects and modulates nitric oxide production.

Cell Research(from reference)

Cell lines：primary cortical neurons 

Concentrations：0.5 and 1 µM 

Incubation Time：4 h 

Specifications

Synonyme

Indolo[2',​3':3,​4]​pyrido[2,​1-​b]​quinazolin-​5(7H)​-​one,8,​14-​dihydro-​14-​methyl-​,hydrochloride (1:1)

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Dehydroevodiamine (DHE), a major phytochemical in fruits of Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Produkteigenschaften

ALogP

2.891

hba_count

2

Namen und Kennungen

Kanonisches Lächeln

Cl.CN1C2=CC=CC=C2C(=O)N3CCC4=C5C=CC=CC5=NC4=C13

Molekulargewicht

337.8

Reaxy-Rn

5326818

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5326818&ln=

Chemische und physikalische Eigenschaften

• DMSO (mg/ml) Maximale Löslichkeit: 37
• DMSO (mM) Maximale Löslichkeit: 109.5322676

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 111664-82-5, the molecular formula is C19H15N3O.HCl, and the molecular weight is 337.8 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.