Deltarasin hydrochloride - 10mM in DMSO , CAS No.1613404-76-4

CAS: 1613404-76-4 Cat. No.: D655480 Summenformel: C₄₀H₃₈ClN₅O Molekulargewicht: 640.22 PubChem CID: 78357804

QUALITÄT & REINHEIT 10mM in DMSO

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Deltarasin hydrochloride is an inhibitor of KRAS-PDEδ interaction with K d of 38 nM for binding to purified PDEδ.

In Vitro

In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with K D of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Kd: 38 nM (PDEδ)

Spezifikationen

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Deltarasin hydrochloride is an inhibitor of KRAS-PDEδ interaction with K d of 38 nM for binding to purified PDEδ.

Storage

Desiccated,Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

Isomere SMILES

C1CNCCC1[C@@H](COC2=CC=C(C=C2)C3=NC4=CC=CC=C4N3CC5=CC=CC=C5)N6C7=CC=CC=C7N=C6C8=CC=CC=C8.Cl

Alternative CAS-Nummer

1440898-82-7

PubChem CID

78357804

Molekulargewicht

640.22