Dexrazoxane HCl (ICRF-187) - 10mM in DMSO , CAS No.149003-01-0

CAS: 149003-01-0 Cat. No.: D408112 Summenformel: C₁₁H₁₆N₄O₄·HCl Molekulargewicht: 304.73

GRADE & PURITY 10mM in DMSO

Synonyms

ADR-529 | 4,​4'-​[(1S)​-​1-​methyl-​1,​2-​ethanediyl]​bis-​2,​6-​piperazinedione, hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Dexrazoxane HCl (ICRF-187, ADR-529) is an intracellulariron chelator, which decreases the formation of superoxide radicals, used as acardioprotectiveagent; also an inhibitor oftopoisomerase II
In vitro

Dexrazoxane (10 mM), known clinically to limit anthracycline cardiac toxicity, prevents daunorubicin-induced myocyte apoptosis, but not necrosis induced by higher anthracycline concentrations in rat cardiac myocytes. Dexrazoxane presumably exerts its cardioprotective effects by either binding free or loosely bound iron, or iron complexed to doxorubicin, thus preventing or reducing site-specific oxygen radical production that damages cellular components. Dexrazoxane specifically abolishes the DNA damage signal gamma-H2AX induced by doxorubicin, but not camptothecin or hydrogen peroxide, in H9C2 cardiomyocytes. Dexrazoxane also induces rapid degradation of Top2beta, which paralleles the reduction of doxorubicin-induced DNA damage. Dexrazoxane antagonizes doxorubicin-induced DNA damage through its interference with Top2beta, which could implicate Top2beta in doxorubicin cardiotoxicity. Dexrazoxane is hydrolyzed to its active form intracellularly and binds iron to prevent the formation of superhydroxide radicals, thus preventing mitochondrial destruction.

In vivo

Dexrazoxane combined with doxorubicin, daunorubicin, or idarubicin reduces the tissue lesions in B6D2F1 mice (expressed as area under the curve of wound size times duration) by 96%, 70%, and 87%, respectively. Dexrazoxane combined with doxorubicin, daunorubicin, or idarubicin results in a statistically significant reduction in the fraction of mice with wounds as well as the duration of wounds.
Cell Data

cell lines：

Concentrations：30 μM

Incubation Time：3 h

Powder Purity:

Specifications

Synonyme

ADR-529 | 4,​4'-​[(1S)​-​1-​methyl-​1,​2-​ethanediyl]​bis-​2,​6-​piperazinedione, hydrochloride (1:1)

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Dexrazoxane HCl (ICRF-187, ADR-529) is an intracellular iron chelator, which decreases the formation of superoxide radicals, used as a cardioprotective agent; also an inhibitor of topoisomerase II

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Namen und Kennungen

• Isomere SMILES: C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.Cl
• Alternative CAS-Nummer: 1263283-43-7
• Molekulargewicht: 304.73

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 47 mg/mL (202.0 mM); Ethanol: 47 mg/mL (202.0 mM); Water: Insoluble

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 149003-01-0, the molecular formula is C11H17ClN4O4, and the molecular weight is 304.73 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.