Diamide - ≥97%(HPLC) , CAS No.10465-78-8

CAS: 10465-78-8 Cat. No.: D165635 Molecular Weight: 172.19 Beilstein Registry Number: 1910410 EC Number: 233-951-7

GRADE & PURITY ≥97%(HPLC)

Synonyms

TMAD | (+/-)-Secobarbital | Azodicarboxylic acid bis-dimethylamide | TMAD | 1,N-dimethylformamide) | BP-10037 | FT-0642495 | N,N',N'-Tetramethylazobisformamide | CCG-204490 | CHEBI:6863 | NSC 143013 | NCGC00093824-02 | GTPL7505 | N,N,N',N'-Tetramethylazod

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Specifications

Synonyms

TMAD | (+/-)-Secobarbital | Azodicarboxylic acid bis-dimethylamide | TMAD | 1, N-dimethylformamide) | BP-10037 | FT-0642495 | N, N', N'-Tetramethylazobisformamide | CCG-204490 | CHEBI:6863 | NSC 143013 | NCGC00093824-02 | GTPL7505 | N, N, N', N'-Tetramethylazod

Specifications & Purity

≥97%(HPLC)

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥97%(HPLC)

Names and Identifiers

• Pubchem Sid: 504763663
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504763663
• Canonical Smiles: CN(C)C(=O)N=NC(=O)N(C)C
• IUPAC Name: (3E)-3-(dimethylcarbamoylimino)-1,1-dimethylurea
• InChIKey: VLSDXINSOMDCBK-BQYQJAHWSA-N
• INCHI: 1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
• Isomeric SMILES: CN(C)C(=O)/N=N/C(=O)N(C)C
• WGK Germany: 3
• RTECS: LQ1041000
• Molecular Weight: 172.19
• Beilstein: 1910410
• Reaxy-Rn: 1910409
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1910409&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Organic carbonic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Organic carbonic acids and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Organic carbonic acids and derivatives
• Alternative Parents: Azo compounds Propargyl-type 1,3-dipolar organic compounds Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Carbonic acid derivative - Azo compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as organic carbonic acids and derivatives. These are compounds comprising the organic carbonic acid or a derivative thereof.
• External Descriptors: 1,1'-azobis(N,N-dimethylformamide)

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

VDR Tclin Vitamin D receptor (26531 Activities)

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ARSA Tbio Cerebroside-sulfatase (655 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

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PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

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MPHOSPH8 Tbio M-phase phosphoprotein 8 (656 Activities)

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Associated Targets(non-human)

Mycobacterium tuberculosis (203094 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

Discover Target: pfk

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

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Mycobacterium tuberculosis variant bovis BCG (1626 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

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Mechanisms of Action

Chemical and Physical Properties

• Solubility: water: 19.60-21.00 mg/mL, clear to slightly hazy, orange
• Sensitivity: air sensitive；heat sensitive
• Melt Point(°C): 113-115 °C
• Molecular Weight: 172.190 g/mol
• XLogP3: 0.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 172.096 Da
• Monoisotopic Mass: 172.096 Da
• Topological Polar Surface Area: 65.300 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 188.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1