Diazoxide - Moligand™, ≥98% , Activator of K ir6.1;Activator of K ir6.2, CAS No.364-98-7, Activator of K ir6.1;Activator of K ir6.2

CAS: 364-98-7 Cat. No.: D136582 Summenformel: C₈H₇ClN₂O₂S Molekulargewicht: 230.67 EG-Nummer: 206-668-1

GRADE & PURITY Moligand™, ≥98%

Synonyms

MFCD00078578 | Diazoxido | EINECS 206-668-1 | SMR000058392 | 7-Chloro-3-methyl-2H-1,4-benzothiadiazine 1,1-dioxide | DTXCID902914 | 7-chloro-3-methyl-4H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide | Bio1_000036 | DIAZOXIDE [EP MONOGRAPH] | Diazoxidum | NSC76

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Synonyme

MFCD00078578 | Diazoxido | EINECS 206-668-1 | SMR000058392 | 7-Chloro-3-methyl-2H-1,4-benzothiadiazine 1,1-dioxide | DTXCID902914 | 7-chloro-3-methyl-4H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide | Bio1_000036 | DIAZOXIDE [EP MONOGRAPH] | Diazoxidum | NSC76

Spezifikationen & Reinheit

Moligand™, ≥98%

Biochemische und physiologische Mechanismen

Selective K IR 6.x (K ATP ) activator; antihypertensive.

Storage

Store at 2-8°C

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

ACTIVATOR

Mechanismus der Wirkung

Activator of K ir6.1;Activator of K ir6.2

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 488179733
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179733
• Kanonisches Lächeln: CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl
• IUPAC Name: 7-chloro-3-methyl-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide
• InChIKey: GDLBFKVLRPITMI-UHFFFAOYSA-N
• INCHI: 1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
• Isomere SMILES: CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl
• WGK Deutschland: 3
• RTECS: DK8185000
• Molekulargewicht: 230.67
• Reaxy-Rn: 523846
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=523846&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Thiadiazines
      • Subclass Benzothiadiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Thiadiazines
• Subclass: Benzothiadiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: 1,2,4-benzothiadiazine-1,1-dioxides
• Alternative Parents: Imidolactams Benzenoids Aryl chlorides Organosulfonic acids and derivatives Azacyclic compounds Amidines Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 1,2,4-benzothiadiazine-1,1-dioxide - Aryl chloride - Aryl halide - Benzenoid - Imidolactam - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Azacycle - Amidine - Hydrocarbon derivative - Organonitrogen compound - Organochloride - Organohalogen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position.
• External Descriptors: sulfone - organochlorine compound - benzothiadiazine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

KCNJ8 Tbio ATP-sensitive inward rectifier potassium channel 8 (0 Activities)

Discover Target: KCNJ8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ11 Tclin ATP-sensitive inward rectifier potassium channel 11 (1 Activities)

Discover Target: KCNJ11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Löslichkeit: Insoluble in water; Soluble in Dimethylformamide,Alcohol
• Empfindlichkeit: Heat sensitive
• Schmelzpunkt (°C): 332 °C
• Molekulargewicht: 230.670 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 229.992 Da
• Monoisotopic Mass: 229.992 Da
• Topological Polar Surface Area: 66.900 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 360.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referenzen

1. Panqin Ma, Zheng Luo, Qi Wang, Ying Chen, Feng Liu, Changliang Ren, Caisheng Wu, Zibiao Li, Yun-Long Wu.  (2024)  Combined activation of artificial and natural ion channels for disrupting mitochondrial ion homeostasis towards effective postoperative tumor recurrence and metastasis suppression.  Theranostics,      [PMID:38855179] [10.7150/thno.94855]

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 364-98-7, the molecular formula is C8H7ClN2O2S, and the molecular weight is 230.67 g/mol. InChIKey GDLBFKVLRPITMI-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.