Diazoxide - Moligand™, 10mM in DMSO , Activator of K ir6.1;Activator of K ir6.2, CAS No.364-98-7, Activator of K ir6.1;Activator of K ir6.2

CAS: 364-98-7 Cat. No.: D423637 Summenformel: C₈H₇ClN₂O₂S Molekulargewicht: 230.67 EG-Nummer: 206-668-1

QUALITÄT & REINHEIT Moligand™, 10mM in DMSO

Synonyms

diazoxide|364-98-7|Proglycem|Hyperstat|Hypertonalum|Eudemine|Proglicem|Dizoxide|Mutabase|7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide|Diazossido|Diazoxidum|Sch 6783|Sch-6783|Diazoxido|SRG 95213|SRG-95213|C8H7ClN2O2S|Eudemine injection|2H-1,2,4-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Spezifikationen

Synonyme

diazoxide | 364-98-7 | Proglycem | Hyperstat | Hypertonalum | Eudemine | Proglicem | Dizoxide | Mutabase | 7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide | Diazossido | Diazoxidum | Sch 6783 | Sch-6783 | Diazoxido | SRG 95213 | SRG-95213 | C8H7ClN2O2S | Eudemine injection | 2H-1,2,4-

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Selective K IR 6.x (K ATP ) activator; antihypertensive.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

ACTIVATOR

Mechanismus der Wirkung

Activator of K ir6.1;Activator of K ir6.2

Namen und Kennungen

Pubchem Sid

528769653

Kanonisches Lächeln

CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl

IUPAC Name

7-chloro-3-methyl-4H-1λ6,2,4-benzothiadiazine 1,1-dioxide

InChIKey

GDLBFKVLRPITMI-UHFFFAOYSA-N

INCHI

1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

Isomere SMILES

CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl

WGK Deutschland

3

RTECS

DK8185000

Molekulargewicht

230.67

Reaxy-Rn

523846

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=523846&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Thiadiazines
      • Subclass Benzothiadiazines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Thiadiazines
• Subclass: Benzothiadiazines
• Intermediate Tree Nodes: Not available
• Direct Parent: 1,2,4-benzothiadiazine-1,1-dioxides
• Alternative Parents: Imidolactams Benzenoids Aryl chlorides Organosulfonic acids and derivatives Azacyclic compounds Amidines Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 1,2,4-benzothiadiazine-1,1-dioxide - Aryl chloride - Aryl halide - Benzenoid - Imidolactam - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Azacycle - Amidine - Hydrocarbon derivative - Organonitrogen compound - Organochloride - Organohalogen compound - Organic nitrogen compound - Organic oxide - Organopnictogen compound - Organic oxygen compound - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position.
• External Descriptors: sulfone - organochlorine compound - benzothiadiazine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

KCNJ11 Tclin ATP-sensitive inward rectifier potassium channel 11 (1 Activities)

Discover Target: KCNJ11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Empfindlichkeit: Heat sensitive
• Schmelzpunkt (°C): 332 °C
• Molekulargewicht: 230.670 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 229.992 Da
• Monoisotopic Mass: 229.992 Da
• Topological Polar Surface Area: 66.900 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 360.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1