Dimethylamiloride hydrochloride - ≥97% , CAS No.2235-97-4

CAS: 2235-97-4 Cat. No.: D275816 Summenformel: C₈H₁₂ClN₇O.HCl Molekulargewicht: 294.14

GRADE & PURITY ≥97%

Synonyms

DMA.HCl | UNII-52W30K1Q9Q | 3-Amino-5-(N,N-dimethylamino)-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide | 5-(N,N-DIMETHYL) AMILORIDE HYDROCHLORIDE | 5-(N,N)-Dimethylamiloride Hydrochloride | CCG-221321 | Dimethylamiloride hydrochloride | 5-(N,N-Dimethy

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Übersicht

Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.

Application：

5-(N,N-dimethyl)-Amiloride (hydrochloride) has been used to investigate biochemical processes related to the circadian clock in mouse and human cell lines. It can also inhibit sodium-hydrogen exchangers (NHE). NHEs regulate sodium and pH in various tissues.

Specifications

Synonyme

DMA.HCl | UNII-52W30K1Q9Q | 3-Amino-5-(N,N-dimethylamino)-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide | 5-(N,N-DIMETHYL) AMILORIDE HYDROCHLORIDE | 5-(N,N)-Dimethylamiloride Hydrochloride | CCG-221321 | Dimethylamiloride hydrochloride | 5-(N,N-Dimethy

Spezifikationen & Reinheit

≥97%

Biochemische und physiologische Mechanismen

Selective Na + /H + exchange blocker (IC 50 = 6.9 μM). Shows greater potency and selectivity than analog, amiloride. Inhibits proliferation and induces differentiation of HL-60 cells. Shows anti-ischemic effects in vivo.

Storage

Protected from light,Store at -20°C,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥97%

Namen und Kennungen

Pubchem Sid

504766818

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504766818

Kanonisches Lächeln

CN(C)C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N.Cl

IUPAC Name

3-amino-6-chloro-N-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide;hydrochloride

InChIKey

IIUPTHVVXMBJMQ-UHFFFAOYSA-N

INCHI

1S/C8H12ClN7O.ClH/c1-16(2)6-4(9)13-3(5(10)14-6)7(17)15-8(11)12;/h1-2H3,(H2,10,14)(H4,11,12,15,17);1H

Isomere SMILES

CN(C)C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N.Cl

Alternative CAS-Nummer

1214-79-5 (Free Base)

Molekulargewicht

294.14

Reaxy-Rn

26124096

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26124096&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Diazines
      • Subclass Pyrazines
        • Ebene5 Pyrazine carboxylic acids and derivatives
          • Ebene6 Pyrazinecarboxamides

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Diazines
• Subclass: Pyrazines
• Intermediate Tree Nodes: Pyrazine carboxylic acids and derivatives
• Direct Parent: Pyrazinecarboxamides
• Alternative Parents: Dialkylarylamines Acylguanidines Aminopyrazines Aryl chlorides Imidolactams Vinylogous amides Heteroaromatic compounds Amino acids and derivatives Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Carboximidamides Hydrocarbon derivatives Hydrochlorides Organic oxides Organochlorides Organooxygen compounds Organopnictogen compounds Primary amines
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyrazinecarboxamide - Dialkylarylamine - Acylguanidine - Aminopyrazine - Aryl chloride - Aryl halide - Imidolactam - Heteroaromatic compound - Vinylogous amide - Amino acid or derivatives - Guanidine - Carboxylic acid derivative - Azacycle - Carboximidamide - Propargyl-type 1,3-dipolar organic compound - Organic 1,3-dipolar compound - Organooxygen compound - Organonitrogen compound - Organochloride - Organohalogen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Primary amine - Hydrochloride - Organic oxygen compound - Organopnictogen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as pyrazinecarboxamides. These are compounds containing a pyrazine ring which bears a carboxamide.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in DMSO to 10 mM
• Empfindlichkeit: light sensitive
• Molekulargewicht: 294.140 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 293.056 Da
• Monoisotopic Mass: 293.056 Da
• Topological Polar Surface Area: 137.000 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 317.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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