disodium ethydronate - 10mM in Water , ATP inhibitor, CAS No.7414-83-7, ATP inhibitor

CAS: 7414-83-7 Cat. No.: D425768 Summenformel: C₂H₆Na₂O₇P₂ Molekulargewicht: 249.99 EG-Nummer: 231-025-7

GRADE & PURITY 10mM in Water

Synonyms

Etidronate disodium|7414-83-7|Didronel|Disodium etidronate|Sodium etidronate|Sodium ethidronate|Sodium ethydronate|Disodium ethydronate|Didronel R|Turpinal 2NZ|Etidronic Acid Disodium Salt|Disodium ethanol-1,1-diphosphonate|Etidronsaeure dinatriumsalz|Dis

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Etidronate Disodium is a bisphosphonate bone resorption inhibitor. Phosphonate ligands demonstrate a very high affinity for alkali metal ions and form crystals with some difficulty. Organophosphonate chelating compounds are able to prevent precipitation of calcium salts at stoichiometric concentrations which is applicable in corrosion inhibition, water treatment and scale inhibition. Etidronate Disodium is an inhibitor of FDPS.

Specifications

Synonyme

Etidronate disodium | 7414-83-7 | Didronel | Disodium etidronate | Sodium etidronate | Sodium ethidronate | Sodium ethydronate | Disodium ethydronate | Didronel R | Turpinal 2NZ | Etidronic Acid Disodium Salt | Disodium ethanol-1,1-diphosphonate | Etidronsaeure dinatriumsalz | Dis

Spezifikationen & Reinheit

10mM in Water

Biochemische und physiologische Mechanismen

Bisphosphonate. Potent bone resorption inhibitor similar to Risedronate ( Asc 3001 ). Metabolically incorporates into nonhydrolysable analogues of ATP. Active in vivo . Orally active.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Mechanismus der Wirkung

ATP inhibitor

Namen und Kennungen

• Pubchem Sid: 528769992
• Kanonisches Lächeln: CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
• IUPAC Name: disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
• InChIKey: GWBBVOVXJZATQQ-UHFFFAOYSA-L
• INCHI: 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• Isomere SMILES: CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
• RTECS: SZ8562240
• Molekulargewicht: 249.99
• Reaxy-Rn: 5190835
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5190835&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Klasse Organic phosphonic acids and derivatives
      • Subclass Bisphosphonates

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Klasse: Organic phosphonic acids and derivatives
• Subclass: Bisphosphonates
• Intermediate Tree Nodes: Not available
• Direct Parent: Bisphosphonates
• Alternative Parents: Organic phosphonic acids Organopnictogen compounds Organophosphorus compounds Organooxygen compounds Organic sodium salts Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Bisphosphonate - Organophosphonic acid - Organic alkali metal salt - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organic sodium salt - Organic salt - Organophosphorus compound - Organooxygen compound - Aliphatic acyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
• External Descriptors: organic sodium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)

Discover Target: ABCC2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCB11 Tchem Bile salt export pump (2311 Activities)

Discover Target: ABCB11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)

Discover Target: ABCC3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)

Discover Target: ABCC4

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Empfindlichkeit: Heat Sensitive
• Molekulargewicht: 249.990 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 249.938 Da
• Monoisotopic Mass: 249.938 Da
• Topological Polar Surface Area: 141.000 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 206.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3

Referenzen

1. Cao Xia, He Qing, Adu-Frimpong Michael, Shen Xinyi, Rong Wanjing, Li Xiaoxiao, Zhang Jian, Xia Xiaoli, Shi Feng, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing.  (2022)  Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity.  AAPS PHARMSCITECH,  23  (7): (1-13).  [PMID:36207561] [10.1208/s12249-022-02427-1]

2. Ying-Qi Li, Yi Chen, Jia-Yi Fang, Si-Qi Jiang, Ping Li, Fei Li.  (2020)  Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:32173426] [10.1016/j.jep.2020.112764]

3. Fan Xinyu, Zhang Ying, Li Xinyu, Ding Junhui, Huang Jiaolong, Lian Kai, Duan Peng, Hu Chunhui, Xu Junchang.  (2025)  Unraveling Ginsenoside Rg1’s osteoprotective pathways in zebrafish models of glucocorticoid induced osteoporosis via transcriptomics.  Scientific Reports,  15  (1): (1-13).  [PMID:40835685] [10.1038/s41598-025-15284-2]

4. Xinyu Li, Xiaoyang Zhou, Zhiyong Li, Zilu Zhu, Songtao Wang, Jiaolong Huang, Kai Lian, Peng Duan, Chunhui Hu, Yihua Shi.  (2026)  Therapeutic functions of tanshinone IIA in a zebrafish model of glucocorticoid-induced osteoporosis.  Frontiers in Pharmacology,      [PMID:41929250] [10.3389/fphar.2026.1772925]