DM-β-CD - Moligand™, 10 mM in DMSO , CAS No.51166-71-3

CAS: 51166-71-3 Cat. No.: D1496563 Molecular Weight: 1331.36 Beilstein Registry Number: 1679140

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

DM-β-CD (2,6-Di-O-methyl-β-cyclodextrin) is a cyclic molecule consisting of seven glucose units modified with two methyl groups at the 2- and 6-positions. It is usually used as a solubilizer and carrier for poorly soluble drugs in pharmaceutical preparations. Furthermore, it has applications in analytical chemistry, food science, and environmental remediation due to its ability to form clathrates with various guest molecules, such as aromatic compounds, pesticides, and heavy metals.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: COC[C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)OC)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)OC)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)OC)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)OC)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)OC)O[C@@H]8[C@H](O[C@H](O2)[C@@H]([C@H]8O)OC)COC)COC)COC)COC)COC)COC)OC)O
• WGK Germany: 3
• Molecular Weight: 1331.36
• Beilstein: 1679140
• Reaxy-Rn: 16858380
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=16858380&ln=

Chemical and Physical Properties

• Flash Point(°C): 187°C
• Melt Point(°C): 180-182°C

References

1. Hang Li, Qing-Sheng Zhao, Li-Wei Wang, Sen-Lin Chang, Pei-Dong Wang, Bing Zhao.  (2022)  Optimization of cyclodextrin-assisted green extraction of cannabidiol from industrial hemp leaves: Release behavior, permeability, bioactivity, and stability.  INDUSTRIAL CROPS AND PRODUCTS,      [PMID:] [10.1016/j.indcrop.2022.115709]

2. Hang Li, Qing-Sheng Zhao, Sen-Lin Chang, Tan-Ran Chang, Ming-Hui Tan, Bing Zhao.  (2021)  Development of cannabidiol full-spectrum oil/2,6-di-O-methyl-β-cyclodextrin inclusion complex with enhanced water solubility, bioactivity, and thermal stability.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2021.118318]

3. Liyuan Chen, Waixiang Yang, Chuanzhu Gao, Xiali Liao, Jing Yang, Bo Yang.  (2021)  The complexes of cannabidiol mediated by bridged cyclodextrins dimers with high solubilization, in vitro antioxidant activity and cytotoxicity.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2021.117017]

4. Hang Li, Sen-Lin Chang, Tan-Ran Chang, Ying You, Xiao-Dong Wang, Li-Wei Wang, Xiao-Fan Yuan, Ming-Hui Tan, Pei-Dong Wang, Peng-Wei Xu, Wei-Bo Gao, Qing-Sheng Zhao, Bing Zhao.  (2021)  Inclusion complexes of cannabidiol with β-cyclodextrin and its derivative: Physicochemical properties, water solubility, and antioxidant activity.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2021.116070]

5. Ying Chen, Yongchao Yao, Xueying Zhou, Chunyan Liao, Xin Dai, Jie Liu, Yunlong Yu, Shiyong Zhang.  (2019)  Cascade-Reaction-Based Nanodrug for Combined Chemo/Starvation/Chemodynamic Therapy against Multidrug-Resistant Tumors.  ACS Applied Materials & Interfaces,      [PMID:31722522] [10.1021/acsami.9b15848]

6. Xiaoxu Du, Nan Song, Ying-Wei Yang, Guolin Wu, Jianbiao Ma, Hui Gao.  (2014)  Reverse micelles based on β-cyclodextrin-incorporated amphiphilic polyurethane copolymers for protein delivery.  Polymer Chemistry,  5  (18): (5300-5309).  [PMID:] [10.1039/C4PY00278D]

7. Pu Zheng, Xinru Chen, Chunyang Zhao, Jialong Wang, Jianhong Zhang, Xiong Hu, Wenchao Geng, Qianqian Zhao.  (2024)  Integrating strategy to investigate the formation and stabilization mechanisms of Curcumin-Cyclodextrin inclusion complexes: Experimental characterizations and multi-scale computational simulations.  FOOD HYDROCOLLOIDS,      [PMID:] [10.1016/j.foodhyd.2024.110679]