DMPQ dihydrochloride - ≥99% , CAS No.1123491-15-5

CAS: 1123491-15-5 Cat. No.: D276030 Summenformel: C₁₆H₁₄N₂O₂.₂HCl Molekulargewicht: 339.22 EG-Nummer: 802-288-0 PubChem CID: 45073427

GRADE & PURITY ≥99%

Synonyms

5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride | 5,7-Dimethoxy-3-(4-pyridinyl)quinolinedihydrochloride

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

DMPQ dihydrochloride is a potent and selective inhibitor of human platelet-derived growth factor receptor β (PDGFRβ) with an IC50 of 80 nM.

Specifications

Synonyme

5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride | 5,7-Dimethoxy-3-(4-pyridinyl)quinolinedihydrochloride

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

Potent and selective β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) inhibitor (IC 50 = 80 nM). Shows >100-fold selectivity over EGFR, PKA, PKC, p56 and erbB2.

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥99%

Namen und Kennungen

Pubchem Sid

528764207

Kanonisches Lächeln

COC1=CC2=C(C=C(C=N2)C3=CC=NC=C3)C(=C1)OC.Cl.Cl

IUPAC Name

5,7-dimethoxy-3-pyridin-4-ylquinoline;dihydrochloride

InChIKey

YBBAOKYVJCNJIV-UHFFFAOYSA-N

INCHI

1S/C16H14N2O2.2ClH/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11;;/h3-10H,1-2H3;2*1H

Isomere SMILES

COC1=CC2=C(C=C(C=N2)C3=CC=NC=C3)C(=C1)OC.Cl.Cl

PubChem CID

45073427

Molekulargewicht

339.22

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Pyridines and derivatives
      • Subclass Bipyridines and oligopyridines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Pyridines and derivatives
• Subclass: Bipyridines and oligopyridines
• Intermediate Tree Nodes: Not available
• Direct Parent: Bipyridines and oligopyridines
• Alternative Parents: Quinolines and derivatives Anisoles Alkyl aryl ethers Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Bipyridine - Quinoline - Anisole - Phenol ether - Alkyl aryl ether - Benzenoid - Heteroaromatic compound - Azacycle - Ether - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxygen compound - Hydrochloride - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as bipyridines and oligopyridines. These are organic compounds containing two pyridine rings linked to each other.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in water to 100 mM
• Empfindlichkeit: Moisture sensitive
• Molekulargewicht: 339.200 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 338.059 Da
• Monoisotopic Mass: 338.059 Da
• Topological Polar Surface Area: 44.200 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 307.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

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