DOTAP Methyl Sulfate - Moligand™,≥98% , CAS No.144189-73-1

CAS: 144189-73-1 Cat. No.: D292996 Summenformel: C₄₃H₈₃NO₈S Molekulargewicht: 774.19

GRADE & PURITY Moligand™, ≥98%

Synonyms

DOTAP | 18:1 TAP (DOTAP, MS Salt), 1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt), chloroform | N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium methyl sulfate | DOTAP Liposomal Transfection Reagent, N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-t

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Application

Drug Delivery, Surface Modification, PEGylation of Protein, Peptide & Oligo

Übersicht

DOTAP Liposomal Transfection Reagent is a liposome formulation of the cationic lipid DOTAP. Unlike other liposomal reagents, it produces highly efficient transfections both in the presence and absence of serum. It can also be successfully used for in vivo applications. Mixing DOTAP with DNA results in spontaneously formed stable complexes. These complexes can be added directly to the cell culture medium. This method of DNA transfer is very gentle, avoiding the cytotoxic effects commonly encountered with lipofection or other transfection methods.

Specifications

Synonyme

DOTAP | 18:1 TAP (DOTAP, MS Salt), 1,2-dioleoyl-3-trimethylammonium-propane (methyl sulfate salt), chloroform | N,N,N-Trimethyl-2,3-bis(oleoyloxy)propan-1-aminium methyl sulfate | DOTAP Liposomal Transfection Reagent, N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-t

Spezifikationen & Reinheit

Moligand™,≥98%

Storage

Store at -20°C,Argon charged

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 504768367
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504768367
• Kanonisches Lächeln: CCCCCCCCC=CCCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC.COS(=O)(=O)[O-]
• IUPAC Name: 2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;methyl sulfate
• InChIKey: RSMRWWHFJMENJH-LQDDAWAPSA-M
• INCHI: 1S/C42H80NO4.CH4O4S/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;1-5-6(2,3)4/h20-23,40H,6-19,24-39H2,1-5H3;1H3,(H,2,3,4)/q+1;/p-1/b22-20-,23-21-
• Isomere SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC.COS(=O)(=O)[O-]
• WGK Deutschland: 3
• Molekulargewicht: 774.19
• Reaxy-Rn: 34197390
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34197390&ln=

Chemische und physikalische Eigenschaften

• Empfindlichkeit: Air sensitive;Heat sensitive
• Siedepunkt (°C): 100 °C
• Schmelzpunkt (°C): -5 °C
• Molekulargewicht: 774.200 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 37
• Exact Mass: 773.584 Da
• Monoisotopic Mass: 773.584 Da
• Topological Polar Surface Area: 127.000 Ų
• Heavy Atom Count: 53
• Formal Charge: 0
• Complexity: 845.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 2
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 2
• Covalently-Bonded Unit Count: 2

XLogP3

Referenzen

1. Yandong Xie, Xueying Lu, Zhen Wang, Mingxi Liu, Liang Liu, Ran Wang, Kun Yang, Hong Xiao, Jianyong Li, Xianglong Tang, Hongyi Liu.  (2022)  A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma.  Biomaterials Science,  10  (23): (6791-6803).  [PMID:36314541] [10.1039/D2BM01145J]

2. Binke Wang, Xinyu Qi, Ruping Yang, Xu Xu, Shiyao Li, Chunli Zhang, Haitao Yu.  (2025)  Cubosome-based co-delivery of doxorubicin and polydatin for targeted cancer therapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.168855]