Doxylamine Succinate - 10mM in DMSO , Histamine H1 receptor antagonist, CAS No.562-10-7, Histamine H1 receptor antagonist

CAS: 562-10-7 Cat. No.: D424761 Summenformel: C₁₇H₂₂N₂O·C₄H₆O₄ Molekulargewicht: 388.46 EG-Nummer: 209-228-7

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

Doxylamine succinate|562-10-7|Decapryn|Gittalun|Unisom|Hoggar N|Doxylamine (succinate)|Doxylamine succinate salt|Doxy-sleep-aid|Evigoa D|Decapryn Succinate|Doxylamine hydrogen succinate|Alsadorm|Mereprine|Sedaplus|A-H Injection|Doxylamine succinate (1:1)|

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Doxylamine succinate competitively inhibits histamine at H1 receptors with substantial sedative and anticholinergic effects

Spezifikationen

Synonyme

Doxylamine succinate | 562-10-7 | Decapryn | Gittalun | Unisom | Hoggar N | Doxylamine (succinate) | Doxylamine succinate salt | Doxy-sleep-aid | Evigoa D | Decapryn Succinate | Doxylamine hydrogen succinate | Alsadorm | Mereprine | Sedaplus | A-H Injection | Doxylamine succinate (1:1) |

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Doxylamine Succinate is an antihistaminic, sedative, and hypnotic. Doxylamine Succinate is also a H1 histamine receptor antagonist.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

ANTAGONIST

Mechanismus der Wirkung

Histamine H1 receptor antagonist

Namen und Kennungen

Pubchem Sid

528771237

Kanonisches Lächeln

CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O

IUPAC Name

butanedioic acid;N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine

InChIKey

KBAUFVUYFNWQFM-UHFFFAOYSA-N

INCHI

1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

Isomere SMILES

CC(C1=CC=CC=C1)(C2=CC=CC=N2)OCCN(C)C.C(CC(=O)O)C(=O)O

WGK Deutschland

2

RTECS

US9275000

Molekulargewicht

388.46

Reaxy-Rn

3829474

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3829474&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Benzylethers

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Benzylethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzylethers
• Alternative Parents: Pyridines and derivatives Dicarboxylic acids and derivatives Heteroaromatic compounds Trialkylamines Dialkyl ethers Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Not available
• Substituents: Benzylether - Dicarboxylic acid or derivatives - Pyridine - Heteroaromatic compound - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organoheterocyclic compound - Ether - Dialkyl ether - Amine - Organopnictogen compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as benzylethers. These are aromatic ethers with the general formula ROCR' (R = alkyl, aryl; R'=benzene).
• External Descriptors: organic molecular entity

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

VDR Tclin Vitamin D receptor (26531 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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BLM Tchem Bloom syndrome protein (4248 Activities)

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GMNN Tbio Geminin (128009 Activities)

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MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Impa1 Inositol monophosphatase 1 (16203 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Empfindlichkeit: Light sensitive
• Schmelzpunkt (°C): 95-98°C
• Molekulargewicht: 388.500 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 388.2 Da
• Monoisotopic Mass: 388.2 Da
• Topological Polar Surface Area: 100.000 Ų
• Heavy Atom Count: 28
• Formal Charge: 0
• Complexity: 369.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3