E260 - ≥98% , CAS No.1241537-79-0

CAS: 1241537-79-0 Cat. No.: E412119 Summenformel: C₂₄H₃₄N₆S Molekulargewicht: 438.63

QUALITÄT & REINHEIT ≥98%

Synonyms

Fer and FerT inhibitor E260Imidazo[2,​1-​b]​-​1,​3,​4-​thiadiazole,6-​[4-​(1-​methylethyl)​phenyl]​-​2-​[4-​[(4-​methyl-​1-​piperazinyl)​methyl]​-​1-​piperidinyl]​-；6-(4-isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Targets

Fer kinase ; FerT

Spezifikationen

Synonyme

Fer and FerT inhibitor E260Imidazo[2,​1-​b]​-​1,​3,​4-​thiadiazole,6-​[4-​(1-​methylethyl)​phenyl]​-​2-​[4-​[(4-​methyl-​1-​piperazinyl)​methyl]​-​1-​piperidinyl]​-；6-(4-isopropylphenyl)-2-(4-((4-methylpiperazin-1-yl)methyl)piperidin-1-yl)imidazo[2,1-b][1

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

E260 (Fer and FerT inhibitor E260) is a Fer kinase and FerT inhibitor that selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation, and onset of energy-consuming autophagy which decreases the cellular ATP

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Namen und Kennungen

Pubchem Sid

528764325

Kanonisches Lächeln

CC(C)C1=CC=C(C=C1)C2=CN3C(=N2)SC(=N3)N4CCC(CC4)CN5CCN(CC5)C

IUPAC Name

2-[4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl]-6-(4-propan-2-ylphenyl)imidazo[2,1-b][1,3,4]thiadiazole

InChIKey

RFHSWNJYHRAOMP-UHFFFAOYSA-N

INCHI

1S/C24H34N6S/c1-18(2)20-4-6-21(7-5-20)22-17-30-23(25-22)31-24(26-30)29-10-8-19(9-11-29)16-28-14-12-27(3)13-15-28/h4-7,17-19H,8-16H2,1-3H3

Isomere SMILES

CC(C)C1=CC=C(C=C1)C2=CN3C(=N2)SC(=N3)N4CCC(CC4)CN5CCN(CC5)C

Molekulargewicht

438.63

Reaxy-Rn

20663094

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=20663094&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Azoles
      • Subclass Imidazoles
        • Ebene5 Substituted imidazoles
          • Ebene6 Phenylimidazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Azoles
• Subclass: Imidazoles
• Intermediate Tree Nodes: Substituted imidazoles
• Direct Parent: Phenylimidazoles
• Alternative Parents: Bicyclic monoterpenoids Aromatic monoterpenoids Phenylpropanes Cumenes Dialkylarylamines N-methylpiperazines 2-amino-5-substituted-1,3,4-thiadiazoles Piperidines N-substituted imidazoles Heteroaromatic compounds Trialkylamines Azacyclic compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: 5-phenylimidazole - 4-phenylimidazole - P-cymene - Aromatic monoterpenoid - Bicyclic monoterpenoid - Monoterpenoid - Cumene - Phenylpropane - Dialkylarylamine - N-methylpiperazine - N-alkylpiperazine - 2-amino-5-substituted-1,3,4-thiadiazole - Benzenoid - Monocyclic benzene moiety - 1,4-diazinane - N-substituted imidazole - 2-amino-1,3,4-thiadiazole - Piperazine - Piperidine - Thiadiazole - Heteroaromatic compound - Tertiary amine - Tertiary aliphatic amine - Azacycle - Amine - Organic nitrogen compound - Organonitrogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as phenylimidazoles. These are polycyclic aromatic compounds containing a benzene ring linked to an imidazole ring through a CC or CN bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro Ethanol: 15 mg/mL (34.19 mM); DMSO: Insoluble; Water: Insoluble
• Molekulargewicht: 438.600 g/mol
• XLogP3: 4.700
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 438.257 Da
• Monoisotopic Mass: 438.257 Da
• Topological Polar Surface Area: 68.200 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 566.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1