Ebselen - Moligand™, ≥98% , Antioxidant, CAS No.60940-34-3, Antioxidant

CAS: 60940-34-3 Cat. No.: P137293 Summenformel: C₁₃H₉NOSe Molekulargewicht: 274.18 EG-Nummer: 612-054-8

GRADE & PURITY Moligand™, ≥98%

Synonyms

Ebselen, Cystein-Modifikator | HMS502P13 | Lopac-E-3520 | Prestwick0_000740 | SCHEMBL33829 | C042986 | NCGC00024072-04 | CID3194 | AC-1124 | BPBio1_000770 | Bio2_000542 | 2-Phenyl-1,2-benzoselenazol-3-one | BSPBio_002538 | HMS1791D04 | NCGC00015412-01 | B

Storage

Lagerung bei -20°C, Argon geladen

Shipped In

Eistruhe + Eispads

Übersicht

Ebselen ist eine interessante Organoseleniumverbindung mit entzündungshemmenden und antioxidativen Eigenschaften. Ebselen hemmt nachweislich die Enzyme 5-Lipoxygenase (5-LO) und 15-Lipoxygenase (15-LO) in Abwesenheit von Glutathion. Ebselen hemmt auch Cox (Cyclooxygenase), PKC (Proteinkinase C), DECR1 (NADPH) und Mox-1 (NADPH-Oxidase). Die Oxidation von Lipoproteinen niedriger Dichte durch freie Radikale wird durch die antioxidative Wirkung von Ebselen unterdrückt. Ebselen ist ein Inhibitor von Cox-1, Cox-2, NOS, GST und IDO.
Ein Inhibitor von 5-LO, 15-LO, Cox, NADPH und NADPH-Oxidase.

anwendung：

Ebselen wurde als Blocker von spannungsabhängigen Kalziumkanälen (VDCCs) und als Glutathionperoxidase-Mimetikum verwendet, um seine hemmende Wirkung auf die kontraktionsvermittelte Aufnahme von Desoxyglukose (2-DG) im Extensor digitorum longus (schnell zuckenden) Muskel der Maus zu testen

glukozerebrosidase-Inhibitor；Helicase-Inhibitor des Hepatitis-C-Virus

Specifications

Synonyme

Ebselen, Cystein-Modifikator | HMS502P13 | Lopac-E-3520 | Prestwick0_000740 | SCHEMBL33829 | C042986 | NCGC00024072-04 | CID3194 | AC-1124 | BPBio1_000770 | Bio2_000542 | 2-Phenyl-1,2-benzoselenazol-3-one | BSPBio_002538 | HMS1791D04 | NCGC00015412-01 | B

Spezifikationen & Reinheit

Moligand™, ≥98%

Biochemische und physiologische Mechanismen

Eine Organo-Selenium-Verbindung mit antioxidativen Eigenschaften. Hemmt Lipoxygenasen von Säugetieren in Abwesenheit von Thiolgruppen sowie Glutathion-S-Transferase und Papain über die Wechselwirkung mit Cysteinresten. Hemmt auch die Indolamin-2,3-Dioxyge

Storage

Lagerung bei -20°C, Argon geladen

Verschickt in

Eistruhe + Eispads

Note

Moligand™

Mechanismus der Wirkung

Antioxidant

Hinweis

Wenn möglich, sollten Sie die Lösungen noch am selben Tag zubereiten und verwenden. Wenn Sie jedoch Stammlösungen im Voraus herstellen müssen, empfehlen wir Ihnen, die Lösung als Aliquote in dicht verschlossenen Fläschchen bei -20 °C zu lagern. Diese sind in der Regel bis zu einem Monat haltbar. Vor der Verwendung und vor dem Öffnen des Fläschchens empfehlen wir, das Produkt mindestens 1 Stunde lang auf Raumtemperatur kommen zu lassen. Benötigen Sie weitere Ratschläge zur Löslichkeit, Verwendung und Handhabung? Besuchen Sie unsere Seite mit den häufig gestellten Fragen (FAQ) für weitere Informationen.

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 504750646
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504750646
• Kanonisches Lächeln: C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
• IUPAC Name: 2-phenyl-1,2-benzoselenazol-3-one
• InChIKey: DYEFUKCXAQOFHX-UHFFFAOYSA-N
• INCHI: 1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
• Isomere SMILES: C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
• WGK Deutschland: 3
• Molekulargewicht: 274.18
• Reaxy-Rn: 164926
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=164926&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzene and substituted derivatives
• Alternative Parents: Selenazoles Heteroaromatic compounds Lactams Azacyclic compounds Organoselenium compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Monocyclic benzene moiety - Heteroaromatic compound - 1,2-selenazole - Lactam - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organoselenium compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
• External Descriptors: benzoselenazole

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (1 Activities)

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EHMT1 Tchem Histone-lysine N-methyltransferase EHMT1 (1 Activities)

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IDE Tchem Insulin-degrading enzyme (2 Activities)

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EPHX2 Tchem Bifunctional epoxide hydrolase 2 (3 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GALE Tchem UDP-glucose 4-epimerase (1 Activities)

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PMM2 Tchem Phosphomannomutase 2 (1 Activities)

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PHOSPHO1 Tchem Phosphoethanolamine/phosphocholine phosphatase (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPI Tchem Mannose-6-phosphate isomerase (1 Activities)

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MIF Tchem Macrophage migration inhibitory factor (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BBOX1 Tchem Gamma-butyrobetaine dioxygenase (5 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IDO1 Tchem Indoleamine 2,3-dioxygenase 1 (2 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

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INSR Tclin Insulin receptor (5558 Activities)

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ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)

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VDR Tclin Vitamin D receptor (26531 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

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PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

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PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)

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IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)

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ANPEP Tchem Aminopeptidase N (863 Activities)

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MIF Tchem Macrophage migration inhibitory factor (979 Activities)

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POLB Tchem DNA polymerase beta (23632 Activities)

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TRPV1 Tclin Vanilloid receptor (8273 Activities)

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FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 Activities)

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ALDOA Tbio Fructose-bisphosphate aldolase A (1 Activities)

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SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)

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BCHE Tclin Butyrylcholinesterase (7174 Activities)

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APP Tclin Amyloid-beta A4 protein (8510 Activities)

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GLA Tclin Alpha-galactosidase A (5444 Activities)

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ALB Tchem Serum albumin (2651 Activities)

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METAP2 Tchem Methionine aminopeptidase 2 (1512 Activities)

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GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)

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AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 Activities)

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RPS6KA4 Tchem Ribosomal protein S6 kinase alpha 4 (2104 Activities)

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PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 Activities)

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SYK Tclin Tyrosine-protein kinase SYK (7372 Activities)

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PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

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ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

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ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

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ALOX12 Tchem Arachidonate 12-lipoxygenase (3262 Activities)

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HDAC3 Tclin Histone deacetylase 3 (3654 Activities)

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PTK2 Tclin Focal adhesion kinase 1 (4730 Activities)

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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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HK1 Tchem Hexokinase type I (266 Activities)

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MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)

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MET Tclin Hepatocyte growth factor receptor (10718 Activities)

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NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)

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PRKCA Tchem Protein kinase C alpha (5923 Activities)

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EPHX2 Tchem Epoxide hydratase (3844 Activities)

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FYN Tclin Tyrosine-protein kinase FYN (5308 Activities)

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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HDAC9 Tclin Histone deacetylase 9 (708 Activities)

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LYN Tclin Tyrosine-protein kinase Lyn (4251 Activities)

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MPI Tchem Mannose-6-phosphate isomerase (940 Activities)

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ampC Beta-lactamase AmpC (62480 Activities)

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Cruzipain (33337 Activities)

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polC DNA polymerase III (243 Activities)

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Hdac5 Histone deacetylase 5 (5 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Pkm Pyruvate kinase isozymes M1/M2 (66 Activities)

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Streptococcus (3973 Activities)

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Enterococcus (1748 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Enterobacter cloacae (7976 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Staphylococcus epidermidis (22802 Activities)

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Acinetobacter baumannii (41033 Activities)

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Citrobacter freundii (1864 Activities)

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Escherichia coli (133304 Activities)

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Klebsiella oxytoca (929 Activities)

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Morganella morganii (1291 Activities)

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Enterococcus faecium (13803 Activities)

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Listeria monocytogenes (2626 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Saccharomyces cerevisiae (19171 Activities)

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Enterococcus faecalis (29875 Activities)

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Mycolicibacterium smegmatis (8003 Activities)

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Trypanosoma brucei (78846 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Bos taurus (956 Activities)

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Gerbillinae (442 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Human immunodeficiency virus 1 (70413 Activities)

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Salmonella enterica (1497 Activities)

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Streptococcus sp. 'group A' (3417 Activities)

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CHO (4503 Activities)

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CHO-K1 (1115 Activities)

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PC-12 (7051 Activities)

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HT-22 (3261 Activities)

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Murine-murine hybridoma (mark 3) (19 Activities)

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Luciferase (58 Activities)

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TRXR Thioredoxin reductase (20 Activities)

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lef Anthrax lethal factor (7585 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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Npsr1 Neuropeptide S receptor (260 Activities)

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Luciferin 4-monooxygenase (66902 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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PYK Pyruvate kinase (6726 Activities)

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botA Botulinum neurotoxin type A (1303 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility in water: insoluble Solubility in other solvents: soluble in methanol, ethanol, THF, ethyl acetate, DMSO
• Empfindlichkeit: heat sensitive；Air sensitive
• Schmelzpunkt (°C): 183 °C
• Molekulargewicht: 274.190 g/mol
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 274.985 Da
• Monoisotopic Mass: 274.985 Da
• Topological Polar Surface Area: 20.300 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 275.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

XLogP3

Referenzen

1. Minglu Li, Hui Han, Shengmei Song, Shaomin Shuang, Chuan Dong.  (2021)  AIE-based fluorescent boronate probe and its application in peroxynitrite imaging.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:34118522] [10.1016/j.saa.2021.120044]

2. Yiming Li, Guanhui Chen, Yi He, Xiliu Zhang, Binghui Zeng, Chao Wang, Chen Yi, Dongsheng Yu.  (2019)  Ebselen rescues oxidative-stress-suppressed osteogenic differentiation of bone-marrow-derived mesenchymal stem cells via an antioxidant effect and the PI3K/Akt pathway.  JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY,      [PMID:31345368] [10.1016/j.jtemb.2019.06.002]

3. Yongqin Fan, Junxia Feng, Xudong Yang, Ruike Chen, Dongjie Cui, Chunli Liu, Hangbo Xu, Qisen Xiang, Zhen Jiao, Ruonan Ma.  (2024)  Cold atmospheric plasma degradation of deoxynivalenol in solid and liquid phases and its effect on whole wheat flour quality.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2024.116920]

4. Xionghua Sun, Xuelei Wan, Li Chen, Yadong Cui, Xihua Chen, Jian Zhang, Xiaogang Jiang.  (2025)  Mitomycin induced the senescence of alveolar epithelial cells by targeting peroxiredoxin I.  BIOCHEMICAL PHARMACOLOGY,      [PMID:40139326] [10.1016/j.bcp.2025.116890]

5. Chang Liu, Linhua Li, Li Li, Qingyin Li, Jing Liu, Chunle Zhang, Zhengjiang Cao, Liang Ma, Xiaoxi Zeng, Ping Fu.  (2024)  Ultrasmall Magnolol/Ebselen Nanomicelles for Preventing Renal Ischemia/Reperfusion Injury.  Biomaterials Science,      [PMID:39034872] [10.1039/D4BM00614C]

6. Liqing Wang, Menghan Chen, Hanxue Wang, Qihui Sun, Sujuan Zheng, Xiaoyun Liu, Yong Yang, Rong Rong.  (2025)  Data mining guided affinity ultrafiltration for rapid screening of SARS-CoV-2 3CLpro inhibitors in medicinal herbs.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:40834688] [10.1016/j.jpba.2025.117122]

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?20 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 60940-34-3, the molecular formula is C13H9NOSe, and the molecular weight is 274.18 g/mol. InChIKey DYEFUKCXAQOFHX-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.