Efonidipine hydrochloride monoethanolate - 10mM in DMSO , CAS No.111011-76-8

CAS: 111011-76-8 Cat. No.: E420612 Summenformel: C₃₆H₄₅ClN₃O₈P Molekulargewicht: 714.18 EG-Nummer: 692-145-7

QUALITÄT & REINHEIT 10mM in DMSO

Synonyms

Efonidipine hydrochloride ethanol | NZ 105 ethanolate | EFONIDIPINE HCL MONOETHANOLATE | NZ-105 hydrochloride monoethanolate | CAS-3113-71-1 | AKOS024457778 | SMR003475016 | Landel (TN) | 1,4-trans-cyclohexane diamine | Q27269529 | Efonidipine hydrochlori

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Racemic efonidipine has both L-type and T-type calcium channel protein inhibitor activity. The R(?)-isomer appears to be very selective for T-type calcium channel. The S(+)-isomer inhibits the expressed Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1 channel currents almost equally.

Spezifikationen

Synonyme

Efonidipine hydrochloride ethanol | NZ 105 ethanolate | EFONIDIPINE HCL MONOETHANOLATE | NZ-105 hydrochloride monoethanolate | CAS-3113-71-1 | AKOS024457778 | SMR003475016 | Landel (TN) | 1,4-trans-cyclohexane diamine | Q27269529 | Efonidipine hydrochlori

Spezifikationen & Reinheit

10mM in DMSO

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

Pubchem Sid

528773754

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/528773754

Kanonisches Lächeln

CCO.CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5.Cl

IUPAC Name

2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;ethanol;hydrochloride

InChIKey

IKBJGZQVVVXCEQ-UHFFFAOYSA-N

INCHI

1S/C34H38N3O7P.C2H6O.ClH/c1-24-30(33(38)42-19-18-36(28-15-9-6-10-16-28)21-26-12-7-5-8-13-26)31(27-14-11-17-29(20-27)37(39)40)32(25(2)35-24)45(41)43-22-34(3,4)23-44-45;1-2-3;/h5-17,20,31,35H,18-19,21-23H2,1-4H3;3H,2H2,1H3;1H

Isomere SMILES

CCO.CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5.Cl

Molekulargewicht

714.18

Reaxy-Rn

5902629

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5902629&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Pyridines and derivatives
      • Subclass Hydropyridines
        • Ebene5 Dihydropyridines
          • Ebene6 Dihydropyridinecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Pyridines and derivatives
• Subclass: Hydropyridines
• Intermediate Tree Nodes: Dihydropyridines
• Direct Parent: Dihydropyridinecarboxylic acids and derivatives
• Alternative Parents: Monocarboxylic acids and derivatives Primary alcohols Organic zwitterions Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Not available
• Substituents: Dihydropyridinecarboxylic acid derivative - Monocarboxylic acid or derivatives - Organic oxygen compound - Hydrocarbon derivative - Hydrochloride - Organic zwitterion - Primary alcohol - Organooxygen compound - Alcohol - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as dihydropyridinecarboxylic acids and derivatives. These are compounds containing a dihydropyridine moiety bearing a carboxylic acid group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemische und physikalische Eigenschaften

• Molekulargewicht: 714.200 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 10
• Exact Mass: 713.263 Da
• Monoisotopic Mass: 713.263 Da
• Topological Polar Surface Area: 143.000 Ų
• Heavy Atom Count: 49
• Formal Charge: 0
• Complexity: 1170.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3