Eltrombopag - Moligand™, 10mM in DMSO , Agonist of Thrombopoietin receptor, CAS No.496775-61-2, Agonist of Thrombopoietin receptor

CAS: 496775-61-2 Cat. No.: E424282 Summenformel: C₂₅H₂₂N₄O₄ Molekulargewicht: 442.47 EG-Nummer: 610-469-9

QUALITÄT & REINHEIT Moligand™, 10mM in DMSO

Synonyms

BCP9000641 | D02363 | CHEBI:85010 | EN300-1709152 | XDXWLKQMMKQXPV-UHFFFAOYSA-N | SB497115 | SB-497115 | 3'-[(2Z)- [1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid | 3'-{2-[1-(

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Eltrombopag is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR).
An agonist of the thrombopoietin receptor

Spezifikationen

Synonyme

BCP9000641 | D02363 | CHEBI:85010 | EN300-1709152 | XDXWLKQMMKQXPV-UHFFFAOYSA-N | SB497115 | SB-497115 | 3'-[(2Z)- [1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid | 3'-{2-[1-(

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

An agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

AGONIST

Mechanismus der Wirkung

Agonist of Thrombopoietin receptor

Namen und Kennungen

Pubchem Sid

528764391

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/528764391

Kanonisches Lächeln

CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C

IUPAC Name

3-[3-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]diazenyl]-2-hydroxyphenyl]benzoic acid

InChIKey

SVOQIEJWJCQGDQ-UHFFFAOYSA-N

INCHI

1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33)

Isomere SMILES

CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)N=NC3=CC=CC(=C3O)C4=CC(=CC=C4)C(=O)O)C

Molekulargewicht

442.47

Reaxy-Rn

35490049

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=35490049&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Klasse Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Klasse: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: Phenylpyrazoles Benzoic acids o-Xylenes Benzoyl derivatives 1-hydroxy-4-unsubstituted benzenoids Pyrazolones Vinylogous amides Heteroaromatic compounds Lactams Azo compounds Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Biphenyl - Phenylpyrazole - Benzoic acid - Benzoic acid or derivatives - O-xylene - Xylene - Benzoyl - 1-hydroxy-4-unsubstituted benzenoid - Phenol - Pyrazolinone - Heteroaromatic compound - Vinylogous amide - Pyrazole - Azole - Lactam - Azo compound - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

MPL Tclin Thrombopoietin receptor (1 Activities)

Discover Target: MPL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemische und physikalische Eigenschaften

• Molekulargewicht: 442.500 g/mol
• XLogP3: 5.400
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 442.164 Da
• Monoisotopic Mass: 442.164 Da
• Topological Polar Surface Area: 115.000 Ų
• Heavy Atom Count: 33
• Formal Charge: 0
• Complexity: 812.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1