Enalaprilat Dihydrate - Moligand™,10mM in DMSO , Angiotensin-converting enzyme inhibitor, CAS No.84680-54-6, Angiotensin-converting enzyme inhibitor

CAS: 84680-54-6 Cat. No.: E408639 Summenformel: C₁₈H₂₄N₂O₅·2H₂O Molekulargewicht: 348.42 EG-Nummer: 689-724-1 PubChem CID: 6917719

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

MK-422 Dihydrate | N-​[(1S)​-​1-​carboxy-​3-​phenylpropyl]​-​L-​alanyl-L-​proline, hydrate (1:2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Enalaprilat (MK-422) is anangiotensin-converting enzyme (ACE)inhibitor withIC50of 1.94 nM.
In vitro

Enalaprilat has high affinity for human endothelial ACE with IC50 of 1.94 nM in vitro binding assay by displacing a saturating concentration of [^125I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykinin/angiotensin I selectivity ratio of 1.00 calculated from double displacement experiments. Enalaprilat has the strong inhibitory effect on Aβ42-to-Aβ40-converting activity found in the N-domain of ACE, exhibiting a 10-fold lower IC50 (0.003~0.01 μM) than captopril (0.03~0.1 μM). Enalaprilat (100 nM) blocks protein kinase C epsilon by directly activating bradykinin B1 receptor at the canonical Zn²⁺ binding site, leading to prolonged nitric oxide (NO) production in cytokine-treated human lung microvascular endothelial cells. Enalaprilat attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with IC50 of 90 mM.

In vivo

Enalaprilat has unfavourable ionisation characteristics to allow sufficient potency for oral administration, thus Enalaprilat is only suitable for intravenous administration, which is overcome by the esterification with ethanol to produce Enalapril. Administration of Enalaprilat induces a significant reduction of MAP at 70 minutes compared with the placebo group during haemorrhagic shock in rats, and results in a 50% reduction of CO, a general tendency of EB extravasation which is significant in the kidney and lungs, and a significant increase in ileal EB extravasation (53%). Enalaprilat has no effect in nonhypertrophied hearts, but significantly attenuates the greater increase in left ventricular end-diastolic pressure in hypertrophied hearts compared with no drug.
Cell Data

cell lines：

Concentrations：Dissolved in DMSO, final concentrations 1 nM - 10 μM

Incubation Time：24 hours

Powder Purity:≥99%

Specifications

Synonyme

MK-422 Dihydrate | N-​[(1S)​-​1-​carboxy-​3-​phenylpropyl]​-​L-​alanyl-L-​proline, hydrate (1:2)

Spezifikationen & Reinheit

Moligand™, 10mM in DMSO

Biochemische und physiologische Mechanismen

Enalaprilat (MK-422) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Angiotensin-converting enzyme inhibitor

Namen und Kennungen

Isomere SMILES

C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)N[C@@H](CCC2=CC=CC=C2)C(=O)O.O.O

WGK Deutschland

3

RTECS

TW3590600

PubChem CID

6917719

Molekulargewicht

348.42

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 3 mg/mL (19.72 mM); Water: Insoluble; Ethanol: Insoluble
• Schmelzpunkt (°C): 151-159°C

Häufig gestellte Fragen

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 84680-54-6, the molecular formula is C18H24N2O5·2H2O, and the molecular weight is 348.42 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.