≥99% für empfindliche chromatographische und analytische Workflows, die minimale Basislinieninterferenzen erfordern.
Store at -20°C,Desiccated Versand Ice chest + Ice pads. Genaue Spezifikationen finden Sie im chargenspezifischen COA.
SDS, COA, Datenblatt und Spezifikationsblatt stehen zum Download bereit. Chargenspezifische COA über Chargennummernsuche abrufbar.
In 0 peer-reviewten Publikationen zu Chromatographie, organischer Synthese und Kreuzkupplungsreaktionen zitiert.
Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with K i s of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs , respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418.
In Vitro
Epiboxidine hydrochloride has affinity and functional at central neuronal α4β2 receptors, with K i s of 0.46 and 1.2 in rat and humen. Epiboxidine hydrochloride has activity at ganglionic-type α3β4*-nicotinic receptors of PC12 cells, with a K i of 19. Epiboxidine hydrochloride is much less toxic than Epibatidine. Epiboxidine hydrochloride stimulates sodium-22 influx in PC12 and TE671 cells, with EC 50 s of 0.18 and 2.6 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Epiboxidine hydrochloride (20 μg/kg; ip; once) treatment shows marked analgetic activity in mice . Epiboxidine hydrochloride (50 and 100 mg/kg; intraperitoneal injected; once) causes marked antinociception as measured in the hot-plate assay. Epiboxidine hydrochloride inhibits [ 3 H]nicotine binding in rat cerebral cortical membranes, with a K i of 0.6 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
Umfassendes Dokument zu Gefahren, Handhabung, Lagerung und Einhaltung regulatorischer Vorschriften.
<<<<<<< HEAD SDS herunterladen → ======= SDS herunterladen → >>>>>>> release248-p3Chargenspezifische Qualitätsdaten. Geben Sie Ihre Chargennummer ein, um das genaue COA abzurufen.
COA nachschlagen →Vollständige Qualitätsmerkmale und Akzeptanzkriterien für diese Qualität.
Spezifikationsblatt ansehen →