Equol - 10mM in DMSO , Estrogen receptor beta agonist, CAS No.531-95-3, Estrogen receptor beta agonist

CAS: 531-95-3 Cat. No.: E407986 Summenformel: C₁₅H₁₄O₃ Molekulargewicht: 242.27 EG-Nummer: 208-522-2

GRADE & PURITY 10mM in DMSO

Synonyms

2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3S)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Equol ,a metabolite of soybeans, is an important isoflavone in humans，specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.
In vitro

Equol is a metabolite produced from the soy phytoestrogen daidzein by the action of gut microflora. Equol has higher affinity for both ERs (estrogen receptors including ERalpha and ERbeta). Equol exists as the enantiomers R-equol and S-equol. S-equol has a high binding affinity, preferential for ERbeta with a K_i of 16 nM whereas R-equol binds more weakly and with a preference for ERalpha K with a K_i of 50 nM. Equol is superior to all other isoflavones in its antioxidant activity. Equol has antioestrogenic properties. Equol is a 100-fold more potent than daidzein in stimulating an oestrogenic response. Equol is also more effective than daidzein in competing with ³ H-oestradiol for binding to the ER. Equol stimulates the growth of MCF-7 cells in a concentration-dependent manner. Although equol exhibits oestrogenic activity, exposure of MCF-7 cells to equol simultaneously with oestradiol is effective in reducing pS2 mRNA expression. Equol results in the downregulation of ER mRNA expression.

In vivo

Cell Data

cell lines：

Concentrations：0 μM-10 μM

Incubation Time：24 hours

Powder Purity:≥99%

Specifications

Synonyme

2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3S)-

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Equol ,a metabolite of soybeans, is an important isoflavone in humans，specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

AGONIST

Mechanismus der Wirkung

Estrogen receptor beta agonist

Produkteigenschaften

ALogP

3

Namen und Kennungen

Isomere SMILES

C1[C@H](COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O

RTECS

DJ2887080

Alternative CAS-Nummer

221054-79-1；94105-90-5

Molekulargewicht

242.27

Reaxy-Rn

87753

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=87753&ln=

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 31 mg/mL (196.0 mM); Water: 31 mg/mL (196.0 mM); Ethanol: Insoluble