Determine the necessary mass, volume, or concentration for preparing a solution.
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature,Argon charged Ships FedEx DG Service Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 13 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
| Pubchem Sid | 504751868 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504751868 |
| Canonical Smiles | CCOC(=O)C(F)(F)F |
| IUPAC Name | ethyl 2,2,2-trifluoroacetate |
| InChIKey | STSCVKRWJPWALQ-UHFFFAOYSA-N |
| INCHI | 1S/C4H5F3O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3 |
| Isomeric SMILES | CCOC(=O)C(F)(F)F |
| WGK Germany | 1 |
| Alternate CAS | 383-63-1 |
| NSC Number | 220215 |
| UN Number | 1993 |
| Packing Group | II |
| Molecular Weight | 142.08 |
| Beilstein | 1761411 |
| Reaxy-Rn | 1761411 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1761411&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Alpha-halocarboxylic acids and derivatives |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Alpha-halocarboxylic acid derivatives |
| Alternative Parents | Carboxylic acid esters Monocarboxylic acids and derivatives Organofluorides Organic oxides Hydrocarbon derivatives Carbonyl compounds Alkyl fluorides |
| Molecular Framework | Aliphatic acyclic compounds |
| Substituents | Alpha-halocarboxylic acid derivative - Carboxylic acid ester - Monocarboxylic acid or derivatives - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organofluoride - Organohalogen compound - Carbonyl group - Alkyl halide - Alkyl fluoride - Aliphatic acyclic compound |
| Description | This compound belongs to the class of organic compounds known as alpha-halocarboxylic acid derivatives. These are carboxylic acid derivatives containing a halogen atom bonded to the alpha carbon atom. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
| Certificate of Analysis | Jun 09, 2026 | E105562 | |
| Certificate of Analysis | Jun 09, 2026 | E105562 | |
| Certificate of Analysis | Mar 09, 2026 | E105562 | |
| Certificate of Analysis | Mar 09, 2026 | E105562 | |
| Certificate of Analysis | Mar 09, 2026 | E105562 | |
| Certificate of Analysis | Mar 09, 2026 | E105562 | |
| Certificate of Analysis | Nov 12, 2025 | E105562 | |
| Certificate of Analysis | Jul 09, 2025 | E105562 | |
| Certificate of Analysis | Jul 09, 2025 | E105562 | |
| Certificate of Analysis | Jul 09, 2025 | E105562 | |
| Certificate of Analysis | Jul 09, 2025 | E105562 | |
| Certificate of Analysis | Jul 09, 2025 | E105562 | |
| Certificate of Analysis | Jun 10, 2025 | E105562 | |
| Certificate of Analysis | Jun 10, 2025 | E105562 | |
| Certificate of Analysis | Dec 16, 2024 | E105562 | |
| Certificate of Analysis | Dec 16, 2024 | E105562 | |
| Certificate of Analysis | Dec 16, 2024 | E105562 | |
| Certificate of Analysis | Dec 16, 2024 | E105562 | |
| Certificate of Analysis | Dec 16, 2024 | E105562 | |
| Certificate of Analysis | Oct 14, 2024 | E105562 | |
| Certificate of Analysis | Oct 14, 2024 | E105562 | |
| Certificate of Analysis | Oct 14, 2024 | E105562 | |
| Certificate of Analysis | Oct 14, 2024 | E105562 | |
| Certificate of Analysis | Jul 12, 2024 | E105562 | |
| Certificate of Analysis | Jul 12, 2024 | E105562 | |
| Certificate of Analysis | Jun 07, 2024 | E105562 | |
| Certificate of Analysis | Jun 07, 2024 | E105562 | |
| Certificate of Analysis | Jun 07, 2024 | E105562 | |
| Certificate of Analysis | Jun 07, 2024 | E105562 | |
| Certificate of Analysis | Jun 07, 2024 | E105562 | |
| Certificate of Analysis | Jan 10, 2024 | E105562 | |
| Certificate of Analysis | Jan 10, 2024 | E105562 | |
| Certificate of Analysis | Aug 15, 2023 | E105562 | |
| Certificate of Analysis | Aug 15, 2023 | E105562 | |
| Certificate of Analysis | Aug 15, 2023 | E105562 | |
| Certificate of Analysis | Aug 15, 2023 | E105562 | |
| Certificate of Analysis | Feb 03, 2023 | E105562 | |
| Certificate of Analysis | Feb 03, 2023 | E105562 | |
| Certificate of Analysis | Feb 03, 2023 | E105562 | |
| Certificate of Analysis | Feb 03, 2023 | E105562 | |
| Certificate of Analysis | Jul 03, 2022 | E105562 | |
| Certificate of Analysis | Jul 03, 2022 | E105562 | |
| Certificate of Analysis | Jul 03, 2022 | E105562 | |
| Certificate of Analysis | Sep 08, 2021 | E105562 |
| Solubility | Slightly miscible with water. Miscible with chloroform and methanol. |
|---|---|
| Sensitivity | Moisture sensitive. |
| Refractive Index | 1.3073 |
| Flash Point(°F) | 30.2 °F |
| Flash Point(°C) | -1℃ |
| Boil Point(°C) | 61.7°C |
| Melt Point(°C) | <-78°C |
| Molecular Weight | 142.080 g/mol |
| XLogP3 | 1.200 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 2 |
| Exact Mass | 142.024 Da |
| Monoisotopic Mass | 142.024 Da |
| Topological Polar Surface Area | 26.300 Ų |
| Heavy Atom Count | 9 |
| Formal Charge | 0 |
| Complexity | 107.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Futing Yang, Wenjie Yu, Qiying Yu, Xiyu Liu, Chunping Liu, Chong Lu, Xinghua Liao, Yi Liu, Na Peng. (2023) Mitochondria-Targeted Nanosystem with Reactive Oxygen Species-Controlled Release of CO to Enhance Photodynamic Therapy of PCN-224 by Sensitizing Ferroptosis. Small, 19 (16): (2206124). [PMID:36693788] [10.1002/smll.202206124] |
| 2. Huan Xu, Mingyue Yang, Yijing Du, Tian Gao, Yi Liu, Liwei Xiong, Na Peng. (2022) Self-assembly of micelles with pH/ROS dual-responsiveness and mitochondrial targeting for potential anti-tumor applications. NEW JOURNAL OF CHEMISTRY, 46 (44): (21235-21244). [PMID:] [10.1039/D2NJ03244A] |
| 3. Yang Yang, Fuwei Yang, Xiaotian Shan, Jiamin Xu, Wenjie Fang, Juan Zhou, Lipeng Qiu, Jinghua Chen. (2021) Fabrication of pH/Reduction Sensitive Polyethylene Glycol-Based Micelles for Enhanced Intracellular Drug Release. Pharmaceutics, 13 (9): (1464). [PMID:34575539] [10.3390/pharmaceutics13091464] |
| 4. Miaomiao Long, Shenhuan Liu, Xiaotian Shan, Jing Mao, Fuwei Yang, Xiaoyu Wu, Lipeng Qiu, Jinghua Chen. (2020) Self-assembly of pH-sensitive micelles for enhanced delivery of doxorubicin to melanoma cells. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.jddst.2020.101859] |
| 5. Xin Ji, Huilong Guo, Qiao Tang, Dong Ma, Wei Xue. (2017) A targeted nanocarrier based on polyspermine for the effective delivery of methotrexate in nasopharyngeal carcinoma. Materials Science & Engineering C-Materials for Biological Applications, [PMID:28888001] [10.1016/j.msec.2017.07.036] |
| 6. Zhixian Huang, Ling Li, Miaomiao Zhou, Haiming Jiang, Ting Qiu. (2015) Isobaric vapor–liquid equilibrium of trifluoroacetic acid + water, trifluoroacetic acid + ethyl trifluoroacetate and ethyl trifluoroacetate + ethanol binary mixtures. FLUID PHASE EQUILIBRIA, [PMID:] [10.1016/j.fluid.2015.08.012] |
| 7. Tianzhi Yu, Yan Cao, Wenming Su, Chengcheng Zhang, Yuling Zhao, Duowang Fan, Mingjun Huang, Kan Yue, Stephen Z. D. Cheng. (2013) Synthesis, structure, photo- and electro-luminescence of an iridium(III) complex with a novel carbazole functionalized β-diketone ligand. RSC Advances, 4 (2): (554-562). [PMID:] [10.1039/C3RA44432E] |
| 8. Chang Hui, Kang Wenjia, Zhao Xinyu, Chang Shuai, Li Xinping, Luo Yuxia, Xiong Chuanyin, Zhu Xunjin, Zhang Zhao. (2025) Nanocellulose chiral synergistic effect enhances circularly polarized luminescence of lanthanide electric dipole transition bands. CELLULOSE, [PMID:] [10.1007/s10570-025-06473-3] |
| 9. Danying Yi, Tao Wang, Shuangshuang Xu, Yuying Liu, Zhonghao Wang, Ning Li, Ye Wu, Yiyan He. (2025) Injectable ROS/pH-Responsive Hydrogel for Synergistic Chemo-Photodynamic Tumor Therapy and Enhanced Wound Healing. Advanced Healthcare Materials, [PMID:40798895] [10.1002/adhm.202502349] |
| 10. Ying Hu, Dandan Wang, Qijie Yu, Ziyi He, Fengrui Deng, Hao Yan, Tinglu Song, Jin-Cheng Zheng, Yang Dai. (2025) The Use of Cognate Cosolvent to Mediate Localized High-Concentration Electrolytes for High-Voltage and Long-Cycling Lithium-Metal Batteries. Batteries-Basel, 11 (4): (156). [PMID:] [10.3390/batteries11040156] |
| 11. Zhaojun Liu, Jiaxuan Feng, Rui Yang, Shen-ao Wang, Xiaochen Wu, Xiangyu Zhang, Sujuan Cheng, Ning Liu, Teng Long, Pengchao Si. (2025) Breaking the 5.5 V barrier: Lithium nitrate-stabilized electrolyte for wide-temperature and high-voltage applications. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.170208] |
| 12. Na Peng, Chun Song, Xiaoting Liu, Michał Nowicki, Roman Szewczyk, Yanyang Wang, Yi Liu. (2025) Mitochondria-Targeted HA-Coated Nanosystem for ROS/CO Generation and Metabolic Reprogramming to Enhance Tumoricidal Macrophage Polarization. ACS Applied Materials & Interfaces, [PMID:41196012] [10.1021/acsami.5c15795] |
| 13. Shichao Zhang, Siyuan Li, Yuezheng Liu, Jin Tang, Xinyang Wang, Wei Zhong, Shulan Mao, Qian Wu, Chaoqiang Tan, Ziren Long, Hao Cheng, Yong Wu, Yingying Lu. (2026) Molecular Engineering of Fluorinated Solvents Enables Practical Lithium Metal Batteries. Advanced Energy Materials, [PMID:] [10.1002/aenm.202506771] |