Ethyl formate - anhydrous, ≥98% , CAS No.109-94-4

CAS: 109-94-4 Cat. No.: E139940 Molecular Weight: 74.08 Beilstein Registry Number: 906769 EC Number: 203-721-0
AVAILABLE TO ORDER
GRADE & PURITY Anhydrous Grade ? Anhydrous grade — water removed and packaged dry for moisture-sensitive chemistry. Use in reactions where even trace water would interfere or quench. ≥98%
Synonyms
ETHYL FORMATE|109-94-4|Formic acid, ethyl ester|Areginal|Ethyl methanoate|Formic acid ethyl ester|Ethyl formic ester|Aethylformiat|Formic ether|Ethylformiaat|Mrowczan etylu|Carboxylic acid oxaethane|Ethyle (formiate d')|Etile (formiato di)|Caswell No. 443
Storage
Room temperature,Desiccated
Shipped In
FedEx DG Service
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Size
Status
Price
Qty
100ml
E139940-100ml
2

$28.90

$38.90
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Why this grade

anhydrous, ≥98% Anhydrous Grade for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Room temperature,Desiccated Ships FedEx DG Service Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 26 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
ETHYL FORMATE | 109-94-4 | Formic acid, ethyl ester | Areginal | Ethyl methanoate | Formic acid ethyl ester | Ethyl formic ester | Aethylformiat | Formic ether | Ethylformiaat | Mrowczan etylu | Carboxylic acid oxaethane | Ethyle (formiate d') | Etile (formiato di) | Caswell No. 443
Specifications & Purity
anhydrous, ≥98%
Storage
Room temperature, Desiccated
Shipped In
FedEx DG Service
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Anhydrous Grade
Purity
≥98%
Names and Identifiers
Canonical SmilesCCOC=O
IUPAC Nameethyl formate
InChIKeyWBJINCZRORDGAQ-UHFFFAOYSA-N
INCHI1S/C3H6O2/c1-2-5-3-4/h3H,2H2,1H3
Isomeric SMILES CCOC=O
WGK Germany 1
RTECS LQ8400000
UN Number 1190
Packing Group II
Molecular Weight 74.08
Beilstein 906769
Reaxy-Rn 906769
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=906769&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
SubclassCarboxylic acid derivatives
Intermediate Tree Nodes Not available
Direct ParentCarboxylic acid esters
Alternative Parents Monocarboxylic acids and derivatives  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAliphatic acyclic compounds
Substituents Carboxylic acid ester - Monocarboxylic acid or derivatives - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
DescriptionThis compound belongs to the class of organic compounds known as carboxylic acid esters. These are carboxylic acid derivatives in which the carbon atom from the carbonyl group is attached to an alkyl or an aryl moiety through an oxygen atom (forming an ester group).
External Descriptors ethyl ester - formate ester
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
D2615339Certificate of AnalysisApr 09, 2026 E139940
D2615341Certificate of AnalysisApr 09, 2026 E139940
C2517085Certificate of AnalysisDec 24, 2024 E139940
C2517183Certificate of AnalysisDec 24, 2024 E139940
D1825017Certificate of AnalysisDec 18, 2023 E139940
C2223553Certificate of AnalysisMay 30, 2022 E139940
C2223555Certificate of AnalysisMay 30, 2022 E139940
C2405111Certificate of AnalysisMay 30, 2022 E139940
F23061521Certificate of AnalysisMay 30, 2022 E139940
L2412209Certificate of AnalysisMay 30, 2022 E139940
Chemical and Physical Properties
SolubilitySoluble in water (105 g/l at 20 °C).
SensitivityMoisture Sensitive
Refractive Index1.359
Flash Point(°F)-4.0 °F - closed cup
Flash Point(°C)-20℃
Boil Point(°C)54°C
Melt Point(°C)-80°C
Molecular Weight74.080 g/mol
XLogP30.500
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass74.0368 Da
Monoisotopic Mass74.0368 Da
Topological Polar Surface Area26.300 Ų
Heavy Atom Count5
Formal Charge0
Complexity26.100
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Citations of This Product
References
1. Busheng Zhang, Liangcai Lin, Canjie Zheng, Xuan Liu, Wanjing Cui, Xin Li, Xiaotong Lyu, Cuiying Zhang.  (2023)  Using in situ untargeted flavoromics analysis to unravel the empty cup aroma of Jiangxiang-type Baijiu: A novel strategy for geographical origin traceability.  FOOD CHEMISTRY,      [PMID:37979271] [10.1016/j.foodchem.2023.137932]
2. Li Qinsheng, Li Yupeng, Li Yaru, Huang Qinghua, Hu Zhongyu, Yang Yuping, Xiong Zhenhua, Cheng Chuanjie.  (2023)  Self-healable polymer networks from bio-based platform chemicals through Passerini and Diels–Alder reactions: a preliminary study.  IRANIAN POLYMER JOURNAL,  32  (10): (1307-1319).  [PMID:] [10.1007/s13726-023-01206-4]
3. Yanrui Wang, Hailin Chang, Shu Jiang, Jialong Chen, Jinlong Wang, Heng Liang, Guibai Li, Xiaobin Tang.  (2023)  An efficient co-solvent tailoring interfacial polymerization for nanofiltration: enhanced selectivity and mechanism.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2023.121615]
4. Wenxia Tian, Xiaofang Liu, Jia Zheng, Yi Ma, Huibo Luo, Xiaogang Luo, Changjun Hou, Danqun Huo.  (2023)  Array-based sensing and discrimination of segmented Baijiu using organic molecules-regulated PEI@Ag NPs@Ln as fluorescent probes.  FOOD CHEMISTRY,      [PMID:36917907] [10.1016/j.foodchem.2023.135888]
5. Xiao-San Li, Mao-Xun Yang, Yu-Hao Luo, He-Hui Zhan, Mei-Fang Chen, Yong-Mei Huang, Li Liu, Xue-Mei Yang.  (2022)  Design, Synthesis and Anticancer Activity of Novel Steroidal Derivatives with D-Ring Fused or Substituted N-Heterocyclic Systems.  CHEMISTRY & BIODIVERSITY,  19  (10): (e202200648).  [PMID:36043381] [10.1002/cbdv.202200648]
6. Bo Lin, Shichao Du, Changyou Yu, Ningning Tian, Weiwei Tang.  (2020)  The effect of solvents on solid-liquid phase equilibrium of Dimethyl sulfone.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2020.112448]
7. Baoqing Bai, Lanqi Zhang, Ying Zhang, Bin Feng, Tao Bo, Jinhua Zhang, Sanhong Fan, Yukun Yang.  (2024)  Comparative analysis of flavor characteristics of two rounds of Qingxiangxing Baijiu by GC×GC-TOFMS, HS-GC-IMS, GC-E-nose and E-tongue.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.105789]
8. Xuan Liu, Lixia Yang, Rao Chen, Mei Han, Chaoqun Yao, Guangwen Chen.  (2024)  Continuous alkylation of 1,3,5-trihydroxy-2,4,6-trinitrobenzene in microreactor: Process intensification and reaction kinetics.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.153544]
9. Qianchun Zhang, Xixi Long, Shan Tang, Li Jiang, Zhaoru Ban, Yanju Chen, Runkun Zhang.  (2024)  Enhanced Cataluminescence Sensor Based on SiO2/MIL-53(Al) for Detecting Isobutylaldehyde.  MOLECULES,      [PMID:39064866] [10.3390/molecules29143287]
10. Bin Ou, Lemei Huang, Shi Su, Yanyan Huang, Zhijia Wang, Xiaobing Liu, Kui Wu.  (2025)  Experimental Study on Binary (Solid + Liquid) Equilibrium and Solubility Analysis of 2-Aminopyrimidine in 17 Organic Solvents at Temperatures Ranging from 272.65 to 323.35 K.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.4c00673]
11. Lin Wang, Hao Jiang, Jun Zhang, Xinhua He, Fangfang Li, Jing Feng, Bo Pan.  (2024)  Identifying the photoproduction sites of reactive oxygen species in dissolved black carbon: A remarkable role of oxygenated functional groups.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2024.123921]
12. Jixiu Deng, Pengshuai Zhang, Han Sun, Wang Rongrong, Binbin Wu, Yuemei Li, Beibei Feng, Haowei Sun, Shuoye Yang.  (2025)  Insight into the solid-liquid equilibrium behavior and apparent thermodynamic analysis of polymorphic pregnenolone (Form Ⅰ) in thirteen neat solvents.  THERMOCHIMICA ACTA,      [PMID:] [10.1016/j.tca.2025.179979]
13. Pengshuai Zhang, Keyi Lu, Han Sun, Chunxia Jin, Ranran Feng, Jixiu Deng, Jiaqi Sun, Shuwei Yu, Beibei Zhang, Lu Zhang, Jianzheng Li.  (2024)  Solid-liquid equilibrium solubility, modeling, Hansen solubility parameter and thermodynamic analysis of 2-Mercaptobenzimidazole in eleven mono-solvents and three binary solvents at different temperatures.  FLUID PHASE EQUILIBRIA,      [PMID:] [10.1016/j.fluid.2024.114036]
14. Jiazhuang Guo, Pan Zhang, Liangliang Zhu, Hao Chen, Hai-Xia Shen, Cai-Feng Wang, Su Chen.  (2024)  Solvent-Engineered Synthesis of Multicolor Emissive Carbon Dots from Citric Acid and Cyanamide.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.4c00136]
15. Zihan Liu, Chaojie Li, Zhiru Yuan, Weiwei He, Lifen Zhang, Zhenping Cheng.  (2024)  Synthesis of Y-Type Fluorinated Surfactant for Aqueous Film-Forming Foam Extinguishing Agent with High Performance.  INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,      [PMID:] [10.1021/acs.iecr.4c00712]
16. Zhaopeng Li, Pei Li, Jinfu Zhang, Helei Yang, Zhiguo Zhu, Hua Zhou, Xia Sun, Zhenhe Wang.  (2025)  NiO/ZnO nanocomposites for high-performance ethyl formate detection in fish meal.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.115025]
17. Pengshuai Zhang, Haiyan Luo, Lan Cui, Jixiu Deng, Shiyu Xie, Danfeng Liu, Shuqi Wang, Xiaoying Si, Zichao Wang, Yameng Wan, En Zhang, Xing Li, Lu Zhang.  (2022)  Assessment of solid–liquid equilibrium behavior and thermodynamic analysis of natural plant extracts artemisinin (Form I) in twelve mono-solvents.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2022.120975]
18. Zhaopeng Li, Pei Li, Peisi Yin, Xin Zhao, Yangting Hu, Fei Sun, Xia Sun, Zhenhe Wang.  (2025)  Jackfruit-like ZnO gas sensor for monitoring ethyl formate emissions from fish meal.  Sensor Review,      [PMID:] [10.1108/SR-01-2025-0014]
19. Bin Ou, Xiaofang Li, Lemei Huang, Xiaobing Liu, Kui Wu.  (2025)  Experimental study on binary (solid + liquid) equilibrium and solubility analysis of N-fluorobenzenesulfonimide in 16 organic solvents at temperatures ranging from 273.35 to 322.85 K under 101.3 kPa.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2025.127526]
20. Wenfeng Huang, Yufeng Wei, Xiaocong Liu, Ruonan Li, Qiuxiang Yin, Lihong Jia.  (2025)  Solubility Measurements and Correlation of Quetiapine Fumarate in 12 Individual Solvents and Tetrahydrofuran–Water from 283.15 to 323.15 K.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.5c00103]
21. Guangping Zhou, Hao Huang, Bo Yang, Xuan Zhou, Huoyan Jiang, Da Zhang, Wanli Zhang, Shaoqu Xie.  (2025)  Rational design of carbon-doped copper catalysts for efficient captured CO2 hydrogenation to methanol.  INTERNATIONAL JOURNAL OF HYDROGEN ENERGY,      [PMID:] [10.1016/j.ijhydene.2025.04.523]
22. Yajun Li, Aoxiang Xu, Jili Zheng, Xianhe Deng, Can Hu, Jun Zhu, Kui Wu.  (2025)  Investigation of the Dissolution Behavior of Diludine in Monosolvents: Solid–Liquid Equilibrium Determination, Model Correlation, and Thermodynamic Analysis.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.5c00370]
23. Ru Zhao, Wenjun Xu, Yuxiang Tang, Jinwen Liu, Xiaoli Li, Liangui Tan, Ailing Ben, Tingli Liu, Lei Yang.  (2025)  Preparation of Lignin Nanoparticles from Thlaspi arvense L. Rhizomes via Ultrasound-Assisted Antisolvent Precipitation: Nanostructural Characterization and Evaluation of Their Radical Scavenging Activity.  MOLECULES,  30  (20): (4070).  [PMID:41157087] [10.3390/molecules30204070]
24. Bin Ou, Xiaofang Li, Lemei Huang, Yujiang Ke, Chaohui Che, Xiaobing Liu, Yajun Li, Kui Wu.  (2025)  Determination of 2-Chlorocinnamic Acid Solubility in 16 Solvents: Model Correlation, Molecular Simulation and Solvent Effects Analysis.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.5c00494]
25. Helei Yang, Pei Li, Jinfu Zhang, Zhiguo Zhu, Hua Zhou, Zhenhe Wang, Xia Sun.  (2025)  Colorimetric ammonia (NH3) sensor based on Cu2+ doped sodium alginate hydrogel and its application in visual monitoring of shrimp freshness.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.116558]
26. Baoqing Bai, Shijie Niu, Junnan Li, Bin Feng, Tao Bo, Jinhua Zhang, Ying Zhang, Yukun Yang.  (2026)  Effects of fermentation with different coarse cereals on antioxidant capacity, flavor profiles and sensory characteristics of Huangjiu.  JOURNAL OF CEREAL SCIENCE,      [PMID:] [10.1016/j.jcs.2026.104389]
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