Evans Blue Staining Solution (0.1%) - BioReagent,Biological Stain,for microscopy,0.1% , CAS No.314-13-6

CAS: 314-13-6 Cat. No.: E1507841 Molecular Weight: 960.81 Beilstein Registry Number: 16(2)259 EC Number: 206-242-5

GRADE & PURITY BioReagent, Biological Stain, for Microscopy, 0.1%

Synonyms

Evans Blue Staining Solution

Storage

Store at 2-8°C,Protected from light

Shipped In

Wet ice

Application

Cell analysis, Cell Staining, Live/Dead Cell Assay

Overview

  Evans Blue, also known as azo blue, has a molecular formula of C₃₄H₂₄N₆Na₄O₁₄S₄, a molecular weight of 960.81, and a CAS number of 314-13-6. As a commonly used azo dye preparation, Evans Blue has a molecular weight similar to that of plasma albumin and high affinity with plasma albumin in the blood. Therefore, it is often used in neuroscience research to trace and observe the integrity of the blood-brain barrier (BBB). It is also used for cell staining to distinguish between live and dead cells, and for blood volume determination. Clinically, Evans Blue is used as a drug to measure plasma and blood volume, and also for the positioning of arterial cannulation. Under normal circumstances, plasma albumin cannot penetrate the blood-brain barrier. Thus, if the BBB in the nervous system remains intact after staining, Evans Blue bound to plasma albumin will not stain the nervous system. On the contrary, if the BBB is damaged, Evans Blue can enter the nervous system and stain it. Evans Blue shows strong absorption peaks at fluorescence wavelengths of 470 nm and 540 nm, and a weak peak at 680 nm, and can be detected by chemical dialysis and colorimetry.

  Both Evans Blue and trypan blue are cell viability dyes, commonly used to detect the integrity of cell membranes and cell viability. Live cells will not be stained blue, while dead cells will be stained light blue. After Evans Blue staining, the cell survival rate can be quantified relatively accurately by direct counting under a microscope or counting after microscopic photography. The most commonly used concentration is 0.5%. Live cells cannot be stained by Evans Blue due to their efflux function, so this method can be used to distinguish dead cells from live cells under a microscope, but cannot distinguish between apoptosis and necrosis. Evans Blue Staining Solution (0.1%) is mainly composed of Evans Blue and phosphate solution. This reagent is for research use only and not for clinical diagnosis or other purposes.

Materials to Be Prepared by Users

1. Syringes, tissue homogenizers

2. PBS (Phosphate-Buffered Saline), trichloroacetic acid, or acetone

Operating Procedures (for Reference Only)

(1) Blood-Brain Barrier Permeability Test

1. Take the treated experimental animals (mice as an example), and inject Evans Blue Staining Solution (0.1%) via the tail vein or femoral vein at a dose of 2-3 ml/kg. Within a few seconds to 1 minute, the mice’s eyes and skin will turn blue. Sacrifice the mice 0.5-1 hour later and collect the target brain tissue.

2. Place the brain tissue in a 1.5 ml centrifuge tube, add 1 ml of PBS, and quickly homogenize the brain tissue using a tissue homogenizer. Centrifuge at 1000×g for 15 minutes.

3. Collect the supernatant, add an equal volume of trichloroacetic acid, and incubate at 4°C for 18-24 hours. Alternatively, the following operation can be adopted: collect the supernatant, add acetone at a ratio of supernatant:acetone = 3:7, and incubate at room temperature for 24 hours.

4. Centrifuge at 1000×g for 20-30 minutes or at 2000×g for 15 minutes.

5. Take 1-2 ml of the above solution, measure the absorbance (OD value) at 620 nm using a spectrophotometer. Meanwhile, determine the OD values of standard Evans Blue solutions with different gradients, draw a standard curve, and calculate the Evans Blue content in the sample to be tested based on the standard curve.

(2) Live Cell Staining

1. Take 100 μl of resuspended cells into a conventional 1.5 ml or 0.5 ml centrifuge tube, add 100 μl of Evans Blue Staining Solution (0.1%), mix gently, and stain for 3 minutes (the staining time can be appropriately extended but should not exceed 10 minutes).

2. Aspirate a small amount of stained cells and count them using a hemocytometer. For relatively accurate quantification, at least 500 cells should be counted for each cell sample, and the number of blue cells and the total number of cells should be recorded. The calculation formula is as follows:

Cell Survival Rate = [(Total Number of Cells - Number of Blue Cells) / Total Number of Cells] × 100%

(3) Seed Staining

1. Use a blade to make cross-sections and accurate longitudinal sections along the center of the seed embryo, then immerse the sections in the staining solution for 3-5 minutes.

2. Soak the stained sections in distilled water for 20-60 minutes, depending on the degree of decolorization.

(4) IFA Counterstaining for Paraffin Sections

1. Perform routine slide baking and dewaxing.

2. Incubate with the secondary antibody containing Evans Blue at a specific concentration (0.1%) for counterstaining, lasting 30 minutes.

3. Mount the sections with buffered glycerol and observe under a microscope.

(5) Viable Cell Detection in Intact Plant Leaves

1. Take the leaves treated with stress, wash them thoroughly with pure water, dry them, and soak them in 0.25% (W/V) Evans Blue solution for 24 hours.

2. Rinse the surface of the leaves with clean water to remove the blue staining solution, blot the surface moisture, and immerse the leaves in boiling absolute ethanol:glycerol (9:1) solution for 30 minutes. Continue until chlorophyll is removed and the leaves turn pale, then take photos to record the leaves with blue spots.

3. Cut the leaves into pieces, place them in 4 mL of 1% SDS solution for extraction over 3 days. Use leaves fully stained blue by Evans Blue (after boiling in water for 15-20 minutes) as the control. Measure the absorbance of the extract at 600 nm.

Precautions

1. Evans Blue Staining Solution (0.1%) has slight toxicity to the human body; please take careful protective measures.

2. During cell staining, note that apoptotic bodies may occasionally exhibit dye exclusion (i.e., not be stained).

3. In the blood-brain barrier permeability test, the injection volume of Evans Blue Staining Solution (0.1%) should be adjusted according to the type and weight of the experimental animals.

4. It is recommended to use a low-temperature refrigerated centrifuge for centrifugation.

5. For your safety and health, please wear a lab coat and disposable gloves during operation.

Specifications

Synonyms

Evans Blue Staining Solution

Specifications & Purity

BioReagent, Biological Stain, for microscopy, 0.1%

Stability And Storage

Store at 2-8℃ long term (12 months). Store in the dark.

Storage

Store at 2-8°C, Protected from light

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Biological Stain, BioReagent, for Microscopy

Names and Identifiers

• Isomeric SMILES: CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(C4=C(C=C3)C(=CC(=C4N)S(=O)(=O)[O-])S(=O)(=O)[O-])O)C)N=NC5=C(C6=C(C=C5)C(=CC(=C6N)S(=O)(=O)[O-])S(=O)(=O)[O-])O.[Na+].[Na+].[Na+].[Na+]
• WGK Germany: 3
• RTECS: QJ6440000
• Molecular Weight: 960.81
• Beilstein: 16(2)259
• Reaxy-Rn: 7110511
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7110511&ln=

Chemical and Physical Properties

• Sensitivity: Light-sensitive

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54. Zhixiao Liu, Liang Wang, Zhiming Mi, Sizhuo Jin, Daming Wang, Xiaogang Zhao, Hongwei Zhou, Chunhai Chen.  (2019)  A carboxyl potassium salt polysulfone (PSF-COOK)-embedded mixed matrix membrane with high permeability and anti-fouling properties for the effective separation of dyes and salts.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2019.06.063]

55. Hu Peilin, Du Jie, Zhang Shuai, Wang Ting, Li Jun, Chen Gang, Zhou Guangqian.  (2019)  Oral Administration of Strontium Gluconate Effectively Reduces Articular Cartilage Degeneration Through Enhanced Anabolic Activity of Chondrocytes and Chondrogenetic Differentiation of Mesenchymal Stromal Cells.  BIOLOGICAL TRACE ELEMENT RESEARCH,  193  (2): (422-433).  [PMID:31054068] [10.1007/s12011-019-01711-9]

56. Zaigang Zhou, Baoli Zhang, Haoran Wang, Ahu Yuan, Yiqiao Hu, Jinhui Wu.  (2018)  Two-stage oxygen delivery for enhanced radiotherapy by perfluorocarbon nanoparticles.  Theranostics,      [PMID:30429876] [10.7150/thno.27598]

57. Dan Zhao, Juan Chen, Ya Zhang, Hua-Bao Liao, Zhi-Feng Zhang, Yang Zhuang, Meng-Xian Pan, Jun-Chun Tang, Rui Liu, Yang Lei, Shu Wang, Xing-Ping Qin, Yu-Gong Feng, Yun Chen, Qi Wan.  (2018)  Glycine confers neuroprotection through PTEN/AKT signal pathway in experimental intracerebral hemorrhage.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,      [PMID:29698679] [10.1016/j.bbrc.2018.04.171]

58. Hengli Zhao, Xuan Zhang, Zhiqiang Dai, Yang Feng, Qiang Li, John H. Zhang, Xin Liu, Yujie Chen, Hua Feng.  (2016)  P2X7 Receptor Suppression Preserves Blood-Brain Barrier through Inhibiting RhoA Activation after Experimental Intracerebral Hemorrhage in Rats..  Scientific Reports,      [PMID:26980524] [10.1038/srep23286]

59. Ce Zhang, Jia Zheng, Xueping Yu, Binglin Kuang, Xiaohong Dai, Lei Zheng, Weiwei Yu, Wei Teng, Hongtao Cao, Mingyue Li, Jiayong Yao, Xiaoying Liu, Wei Zou.  (2024)  “Baihui” (DU20)-penetrating “Qubin” (GB7) acupuncture on blood–brain barrier integrity in rat intracerebral hemorrhage models via the RhoA/ROCK II/MLC 2 signaling pathway.  Animal Models and Experimental Medicine,      [PMID:38379356] [10.1002/ame2.12374]

60. Yixuan Ma, Yimin Huang, Xuyang Liu, Liwu Jiao, Hongtao Zhu, Zhiye Chen, Zhuojin Wu, Yuanzhong Shen, Kehan Lin, Feng Hu, Kai Shu.  (2025)  Aquaporin‑1 regulates microglial polarization and inflammatory response in traumatic brain injury.  INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,  55  (3): (1-14).  [PMID:39749692] [10.3892/ijmm.2025.5482]

61. Bian Xufei, Guo Qian, Yau Lee-Fong, Yang Ling, Wang Xiaoyou, Zhao Shikang, Wu Shiqiong, Qin Xurong, Jiang Zhi-Hong, Li Chong.  (2025)  Berberine-inspired ionizable lipid for self-structure stabilization and brain targeting delivery of nucleic acid therapeutics.  Nature Communications,  16  (1): (1-16).  [PMID:40064874] [10.1038/s41467-025-57488-0]

62. Ruilong Li, Yongjian Yang, Jingjing Chen, Chongchong Chen, Wenpeng Li, Xiaoli Wu, Jingtao Wang.  (2024)  Channel–molecule attraction mediated molecule transport in confined nanochannels of COF membranes for nanofiltration.  AICHE JOURNAL,      [PMID:] [10.1002/aic.18719]

63. Li Wang, Meng Zhang, Yufei Shu, Qi Han, Li Long, Beizhao Chen, Mengxia Wang, Li Li, Siyu Cao, Zhe Yang, Bei Liu, Zhongying Wang, Chuyang Y. Tang.  (2024)  Covalently modified MoS2 for the fabrication of interlayered thin film composite membranes with excellent structural stability against swelling and drying in organic solvent nanofiltration.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.122985]

64. Chao Wang, Yujia Lu, Peijuan Chu, Tengfei He, Lijia Liu, Chunhong Zhang.  (2024)  Design of intrinsically antibacterial thin film composite membrane based on natural material for efficient molecular sieving.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2024.129798]

65. Luyao Liu, Ruikun Wang, Weijuan Gao, Xianming Hou, Xiaofei Jin, Yanmeng Zhao, Xiaohong Zhou, Yi Zhang.  (2024)  Drug pairs of Huangqi and Danggui alleviates pyroptosis by promoting autophagy activity via AMPK/mTOR signaling pathway in middle-cerebral artery occlusion/reperfusion in rats.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:39454707] [10.1016/j.jep.2024.118982]

66. Wang Zhenhua, Li Yuan, Wang Zhixu, Liao Yuhui, Ye Qingqing, Tang Shilong, Wei Ting, Xiao Pengyu, Huang Juan, Lu Weitian.  (2024)  Edaravone Maintains AQP4 Polarity Via OS/MMP9/β-DG Pathway in an Experimental Intracerebral Hemorrhage Mouse Model.  MOLECULAR NEUROBIOLOGY,      [PMID:38421470] [10.1007/s12035-024-04028-4]

67. Xiao-lei ZHANG, Meng-ni HU, Ya-nan LI, Yao WANG, Zhen RONG, Jun MA.  (2025)  Effect of electroacupuncture on MMP-2/9 pathway mediated the blood-brain barrier permeability in mice with Parkinson's disease.  World Journal of Acupuncture-Moxibustion,      [PMID:] [10.1016/j.wjam.2025.01.002]

68. Yisa Zhou, Ya Zhang, Jian Xue, Rui Wang, Jiale Dong, Zongjie Yin, Chen Guo, Haihui Wang.  (2024)  Electrochemically assisted preparation of graphitic carbon nitride nanosheet membranes for efficient water purification.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.151638]

69. Xiaonan Li, Qi Qiao, Xiong Liu, Qian Hu, Yulin Yu, Xianya Qin, Tianyi Tian, Yinmei Tian, Xiangjun Ou, Boning Niu, Conglian Yang, Li Kong, Zhiping Zhang.  (2024)  Engineered Biomimetic Nanovesicles Based on Neutrophils for Hierarchical Targeting Therapy of Acute Respiratory Distress Syndrome.  ACS Nano,      [PMID:38166370] [10.1021/acsnano.3c09848]

70. Xuan Wang, Jiaojiao Duan, Weiliang Li, Xiaoli Wu, Yong Wang, Mingjie Wei, Yifan Li, Runnan Zhang, Jingtao Wang.  (2025)  Evaluation of the Stability of β-Ketoenamine-Type Covalent Organic Framework Membranes in Organic Solvent.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2025.124052]

71. Gao Tao, Zhang Huaisheng, Xu Yuan, He Guosong, Ma Huicong, Zheng Chuanming, Li Lei, Cheng Feng, Dou Hehe, Zhang Fulong, Zhao Heng, Qiu Zhaolei.  (2025)  HIF-1α Enhances Intestinal Injury and Inflammation in Severe Acute Pancreatitis Through NLRP3 Inflammasome Activation.  DIGESTIVE DISEASES AND SCIENCES,      [PMID:39998719] [10.1007/s10620-025-08926-y]

72. Ruixue Meng, Xinxin Wang, Deping Li, Kewei Zhang, Xiankai Li, Yanhui Li, Long Chen, Lijie Ci.  (2024)  High antifouling graphene membranes with Fe2O3 nanoparticles in-situ intercalation for selective dye/salt separation.  DESALINATION,      [PMID:] [10.1016/j.desal.2024.117919]

73. Heguo Han, Zheng Liu, Huiting Yu, Yuxuan Sun, Shenghai Li, Suobo Zhang.  (2024)  Imine-linked integrally crosslinked thin-film composite membrane for organic solvent nanofiltration.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.123490]

74. Mengying Long, Luhui Yang, Niaz Ali Khan, Chao Yang, Guangwei He, Tao Wu, Dongmin An, Zhongyi Jiang.  (2025)  In-situ crystallization of covalent organic framework fillers in mixed matrix membranes via the reactive surface segregation approach.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.116387]

75. Yun-Han Ren, Wen-Hai Zhang, Ming-Jie Yin, Zhi-Jie Liu, Quan-Fu An.  (2024)  In-situ nanoparticles intercalating graphene oxide membranes for superior water transport in dye desalination.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.122544]

76. Yuhan Han, Weiji Weng, Yongkang Zhang, Qiyuan Feng, Yuxiao Ma, Ankang Quan, Xianhua Fu, Xinxin Zhao, Loren Skudder-Hill, Jiyao Jiang, Yan Zhou, Honglin Chen, Junfeng Feng.  (2024)  Intraoperative application of intelligent, responsive, self-assembling hydrogel rectifies oxygen and energy metabolism in traumatically injured brain.  BIOMATERIALS,      [PMID:38309053] [10.1016/j.biomaterials.2024.122495]

77. Kai Xu, Yu Zheng, Junjie Zhou, Yang Zhao, Xiao Pang, Lijuan Cheng, Hui Wang, Xianjuan Zhang, Runnan Zhang, Zhongyi Jiang.  (2024)  Microwave-Assisted Fabrication of Highly Crystalline, Robust COF Membrane for Organic Solvent Nanofiltration.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202417383]

78. Zheng Xiao-Bo, Wang Xue, Gao Sheng-Qing, Gao Chao-Chao, Li Tao, Han Yan-Ling, Zhao Ran, Sun Yan, Miao Shu-Hao, Qiu Jia-Yin, Jin Wang-Xuan, Zhou Meng-Liang.  (2025)  NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury.  Cell Death Discovery,  11  (1): (1-15).  [PMID:39979243] [10.1038/s41420-025-02350-x]

79. Jian Wang, Jun Peng, Ling Gao, Jun He, Long Lin, Jia-Meng Li, Ying Xia.  (2025)  Olfactory mucosa mesenchymal stem cell-derived exosomes protect against neuroinflammation after subarachnoid hemorrhage by activating mitophagy.  KAOHSIUNG JOURNAL OF MEDICAL SCIENCES,      [PMID:39969074] [10.1002/kjm2.12951]

80. Ji Zhang, Kaili Chen, Yizhe Chen, Lingchen Hua, Siping Chen, Xin Chen, Liangyu Zou, Shupeng Li, Xifei Yang, Yuanyuan Shen.  (2024)  Pathology reduction and motor behavior improvement associated with ultrasound-mediated delivery of arctiin to the motor cortex in a mutant SOD1 mouse model of amyotrophic lateral sclerosis.  ULTRASONICS,      [PMID:39217855] [10.1016/j.ultras.2024.107449]

81. Kai Mi, Sen Xiong, Yanqiu Lu, Yong Wang.  (2024)  Precise Fabrication of Robust Conjugated Microporous Polymer Membranes via Oxidative Molecular Layer Deposition for Efficient Organic Solvent Nanofiltration.  CHEMISTRY OF MATERIALS,      [PMID:] [10.1021/acs.chemmater.4c01424]

82. Henan Peng, Hongru He, Pan Chen, Ke Zhang, Chunhai Chen, Daming Wang.  (2024)  Preparation of highly efficient nanofiltration membranes resistant to organic solvents by adjusting zinc oxide nanoparticle-loaded attapulgite.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2024.127004]

83. Xiongfei Du, Yang Li, Kaixuan Sun, Hailiang Liu, Mingxing Chen, Qinglin Huang.  (2024)  Preparation of PMIA loose nanofiltration membrane with electrostatic layer-by-layer self-assembled for dye/salt filtration.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2024.112204]

84. Tingyan Deng, Zhen Cao, Fan Ni, Li Zhao, Fei Shen, Jianmei Zou, Yanzong Zhang, Yating Chen, Jinsong He.  (2024)  Quantitative assessment of structure-performance relationship of loose nanofiltration membranes with TA-MoS2 interlayer for effective dye/salt separation.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2024.129902]

85. Fu Xianhua, Zhang Yongkang, Chen Guojie, Mao Guangyao, Tang Jiajia, Xu Jin, Han Yuhan, Chen Honglin, Ding Lianshu.  (2025)  Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-22).  [PMID:40045354] [10.1186/s12951-025-03251-y]

86. Yuanwei He, Ziyu Chen, Qinglang Liu, Zhiyang Li, Dingsheng Wen, Hong Zhang, Ming Zhang, Di Jiang, Huaan Li, Lu Wen, Gang Chen.  (2024)  Reversible opening of the blood-labyrinth barrier by low-pressure pulsed ultrasound and microbubbles for the treatment of inner ear diseases.  JOURNAL OF CONTROLLED RELEASE,      [PMID:38906419] [10.1016/j.jconrel.2024.06.043]

87. Ying Zhang, Jing Xie, Huimin Zhang, Jiacheng Li, Xing Mi, Xuyi Zhou, Zhenhua Ding.  (2024)  Serum exosomal miRNA promote glioma progression by targeting SOS1 via abscopal effect of radiation.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS,      [PMID:39303929] [10.1016/j.abb.2024.110138]

88. Wen-Hai Zhang, Yun-Han Ren, Ming-Jie Yin, Zhi-Jie Liu, Haiqi Gao, Shuang-Shuang Wang, Zhen-Yuan Wang, Quan-Fu An, Hong Meng.  (2024)  Stable supra-nanosheet graphene oxide membranes for ultrafast water transport.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.123160]

89. Jingjing Chen, Ruilong Li, Siyu Liu, Wenpeng Li, Jie Zhang, Xiaoli Wu, Jingtao Wang.  (2024)  Surfactant-assisted interfacial polymerization towards high-crystallinity COF membranes for organic solvent nanofiltration.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2023.122404]

90. Henan Peng, Pan Chen, Yuqi Wu, Chunhai Chen, Daming Wang.  (2024)  Synergistic preparation of organic solvent nanofiltration membranes from polydopamine/polyethyleneimine interlayers with aminated attapulgite.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2024.129503]

91. Junhui Huang, Yanqiu Zhang, Jing Guo, Zhen Yang, Yongping Bai, Gang Gao, Jiaqi Zhu, Bhekie B. Mamba, Huanting Wang, Lu Shao.  (2024)  Thermostable nanofiltration membranes enabling superior hot wastewater purification.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2024.123216]

92. Jiao Sun, Yiqing Wang, Jiaxing Zhang, Jianhao Wang, Cheng Wang.  (2025)  A drug reservoir strategy for long-acting cancer therapy using morphologically transformed amphiphilic polymeric nanoparticles.  Acta Biomaterialia,      [PMID:40617494] [10.1016/j.actbio.2025.07.006]

93. Menghao Lin, Juan Liu, Wenyu Zhou, Can Deng, Yaohan Du, Lichun Dong, Cailong Zhou.  (2025)  Mixed matrix membranes based on controllable synthesized one-dimensional HOFs for molecular separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2025.124503]

94. Xiaoxiang Cheng, Zhe Xu, Xinsheng Luo, Yi Chai, Jiajian Xing, Xinyu Zhang, Jingtao Xu.  (2025)  Self-limiting interfacial synthesis of inorganic thin films for high-performance organic solvent nanofiltration in pharmaceutical applications.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.134261]

95. Huang Junjun, Wang Luyu, Jia Ziyu, Cheng Kunxia, Han Rongzhi, Yu Juanjuan, Wang Huahua.  (2025)  Involvement of nitric oxide-mediated cytosolic glucose-6-phosphate dehydrogenase in soybean resistance to heavy metal toxicity.  PLANT CELL REPORTS,  44  (8): (1-15).  [PMID:40690014] [10.1007/s00299-025-03565-z]

96. Elham Ghashghaei, Minghui Wang, Ahmed Mijiyawa, Hai Lin.  (2025)  Effects of amino acids methionine, lysine, and taurine on feed intake and mRNA expression of appetite-related neuropeptides in layer-type chicks.  POULTRY SCIENCE,      [PMID:40743628] [10.1016/j.psj.2025.105586]

97. Yu-Zhang Wang, Wei-Hai Chen, Zi-Yi Han, Shi-Man Zhang, Ping Ji, Cheng Zhang, Jun-Long Liang, Xian-Zheng Zhang.  (2025)  Targeted tumor therapy with L-cyst(e)ine-addicted bacteria-nanodrug biohybrids.  Cell Metabolism,      [PMID:40215982] [10.1016/j.cmet.2025.03.012]

98. Doudou Ning, Zhaoqing Lu, Li Hua, Nan Li, Songfeng E.  (2025)  Rational Design of Covalent Organic Framework-Based Membranes with Pore-in-Pore Structure for Efficient Mass Transport.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202525420]

99. Ma Yangguang, Liu Yi, Pan Dongsheng, Zhang Jiawei, Liang Zhuowen, Wang Yi, Hu Xueyu, Wang Zhe, Ding Tan.  (2025)  Photobiomodulation repairs the blood–spinal cord barrier in a mouse model of spinal cord injury.  Neural Regeneration Research,      [PMID:41673789] [10.4103/NRR.NRR-D-24-01098]

100. Fan Yang, Qiangqiang Yang, Jing Guo, Xiaoyu Tan, Junhui Huang, Yanqiu Zhang, Lu Shao.  (2025)  CQD-mediated homogeneous covalent organic framework membranes for ultrafast molecular sieving.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2025.124061]

101. Yan Song, Luyao Wang, Tingting Peng, Lingling Shan, Bo Wan, Mingtan Tang, Yuxia Luan, Yue Jiang, Wenxiu He.  (2025)  Brain-targeting biomimetic nanozyme enhances neuroprotection in ischemic stroke by remodeling the neurovascular unit.  JOURNAL OF CONTROLLED RELEASE,      [PMID:40254137] [10.1016/j.jconrel.2025.113750]

102. Huabin Liu, Chuangyang Bai, Jiahui Cai, Yue Wu, Changwei Zhu.  (2025)  Yucasin Alleviates Aluminum Toxicity Associated with Regulating Reactive Oxygen Species Homeostasis in Tomato Seedlings.  Toxics,  13  (5): (406).  [PMID:40423485] [10.3390/toxics13050406]

103. Siyuan Qiao, Pei Nian, Guisen Yang, Yingfei He, Xingrui Li, Yibin Wei.  (2025)  Preparation of Zr-MOF membranes via vapor-assisted conversion for efficient dye rejection.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.133497]

104. Yue Yu, Yang Liu, Chao Wang, Chang Chen, Qingsong Ye, Zhewei Zhang, Lifeng Luo, Chengjun Song, Chenxuan Zhao, Zhiwen Zou, Yitao Ding, Jinhui Wu.  (2025)  Protein-based embolic agent loaded with ethiodized oil for targeted tumor vascular embolization.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40409614] [10.1016/j.ijbiomac.2025.144503]

105. Henan Peng, Fengqin Hong, Pan Chen, Chunhai Chen, Daming Wang, Hongwei Zhou.  (2025)  Preparation of organic solvent-resistant nanofiltration membranes through copper sulfate (CuSO4)/hydrogen peroxide (H2O2) oxidation triggered polydopamine (PDA)/polyethyleneimine (PEI) deposition interlayer.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.133090]

106. Huacun Li, Mingbo Xie, Zhenghao Wang, Jinkang Liu, Jun Xie, Xu Yan, Qingwei Wang, Meiqing Shi, Liyuan Chai, Liyuan Zhang.  (2025)  Gentle Gradient-Reduction of Graphene Oxide Membranes by Interfacial Redox Reaction toward Breaking Selectivity-Permeability Trade-off.  ACS Applied Materials & Interfaces,      [PMID:40460038] [10.1021/acsami.5c07301]

107. Jia Wenjing, Yue Huilan, Liu Liying, Wang Luya, Zhang Lin, Tao Jihong, Zhou Guoying, Wei Lixin, Dong Hongxin, Dhondrup Rinchen, Zhao Xiaohui.  (2025)  Biosynthesized nanoparticles of Tibetan medicine mercuric sulfide preparation to promote endocytosis and realize drug crossing through blood brain barrier.  JOURNAL OF NANOBIOTECHNOLOGY,  23  (1): (1-26).  [PMID:40524151] [10.1186/s12951-025-03525-5]

108. Yaozhi He, Siyuan Zou, Jiawei Wang, Wenbin Zhang, Sheng Lu, Mengxian Jia, Yumin Wu, Xiaowu Lin, Ziwei Fan, Qishun Liang, Yizhe Sheng, Qichuan Zhuge, Bi Chen, Minyu Zhu, Honglin Teng.  (2025)  Curcumin-loaded milk-derived sEVs fused with platelet membrane attenuate endothelial senescence and promote spinal cord injury recovery in diabetic mice.  Materials Today Bio,      [PMID:40688662] [10.1016/j.mtbio.2025.102036]

109. Xiaoxuan Fei, Junyi Pei, Simin Yan, Weihong Ge, Li Li, Jianjun Zou, Huimin Zhang, Lie Sun, Sifei Han, Luojuan Hu.  (2025)  Subcutaneously administered anti-PD-(L)1 antibodies are predominantly absorbed via the lymphatic system, resulting in high drug exposure to draining lymph nodes.  JOURNAL OF PHARMACEUTICAL SCIENCES,      [PMID:41093037] [10.1016/j.xphs.2025.104026]

110. Yunpeng Zhu, Lingjiang Li, Yunshan Guo, Renji Wang, Yiguang Hao, Xin He.  (2025)  M5C-methylated EDIL3 attenuates spinal cord ischemia-reperfusion injury by suppressing neutrophil extracellular trap formation.  FREE RADICAL BIOLOGY AND MEDICINE,      [PMID:41173315] [10.1016/j.freeradbiomed.2025.10.294]

111. Huangtao Chen, Shaochun Guo, Yanglan Mi, Ruili Han, Yuxin Xi, Tingwei Peng, Longhui Fu, Weidong Liu, Ruiyu Ma, Beibei Yu, Yongfeng Zhang, Luyao Li, Jing Ye, Shouping Gong.  (2025)  Microglial SLC25A28 Knockout Mitigates Spinal Cord Injury in Mice by Inhibiting Heme Synthesis and Subsequent NOX2 Activation.  CNS Neuroscience & Therapeutics,  31  (11): (e70638).  [PMID:41177991] [10.1111/cns.70638]

112. Jiulong Yin, Lei Qi, Na Li, Meng Li, Chao Jiang, Yujian Yao, Xuan Zhang.  (2025)  Brominated monomer-enabled polyester tight ultrafiltration membranes for efficient dye/salt separation and anti-fouling performance.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.136009]

113. Elham Ghashghaei, Ahmed Mijiyawa, Minghui Wang, Morteza Zendehdel, Hai Lin.  (2025)  Central effects of bile acids on feed intake and mRNA expression of appetite-related neuropeptides in layer-type chicks.  POULTRY SCIENCE,      [PMID:41265140] [10.1016/j.psj.2025.106105]

114. Yuqing Shen, Yi Shen, Xuru Wang, Fuhua Wang, Piaopiao Liu, Chen Sun, Ying Zhang, Feng-qin Miao, Jianqiong Zhang, Lixin Wang.  (2025)  LC3-positive extracellular vesicles released from tumor cells promote lung metastasis of breast cancer by inducing vascular permeability.  FEBS Journal,      [PMID:41307630] [10.1111/febs.70335]

115. Xinda You, Zifan Song, Youqing Tian, Ran Chen, Yuxiang Wu, Meijie Wang, Dai Shi, Shan Luo, Jiamei Sun, Yuanhui Xiao, Haixiong Liu, Hanyang Liu, Beili Lu, Lirong Tang, Xingzhong Cao, Jiande Lin, Biao Huang.  (2025)  Coordination-reconstructed cellulose membranes for precise molecular separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2025.125020]

116. Xiaoyue Lai, Xiaoqin Wan, Xinyu Bao, Qingyuan Yang, Wei Zhang, Yan Tan, Xiaoshi Cai, Ziyang Wang, Yujie Li, Chun Liu, Zhongfang Deng, Pan Zheng, Dingyuan Tian, Ming Chen, Hongjun Yin, Gang Xu, Qi Huang, Zhihui Zhang, Hongmei Xia, Fang Deng.  (2025)  5-Methoxytryptophan attenuates hypobaric hypoxia induced acute lung injury by alleviating lipid peroxidation via targeting peroxiredoxin 6.  Redox Biology,      [PMID:41270299] [10.1016/j.redox.2025.103922]

117. Huimin Li, Ziang Wang, Suwei He, Minghui Zhong, Xichen Wang, Weitao Hu, Jingrong Tang, Zhonghao Xiao, Xiaowen Shi, Zigang Cao.  (2025)  2-Hydroxyanthraquinone exposure causes the damage of cerebrovascular and blood brain barrier in zebrafish via inducing inflammation and downregulation of the Wnt/β-catenin signaling pathway.  COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,      [PMID:41386556] [10.1016/j.cbpc.2025.110432]

118. Wenkai Li, Sifan Song, Wenyong Li, Jing Chen.  (2025)  Flavonoid-Rich Extract from Bombyx batryticatus Alleviate LPS-Induced Acute Lung Injury via the PI3K/MAPK/NF-κB Pathway.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  26  (24): (12057).  [PMID:41465486] [10.3390/ijms262412057]

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