Factor XIII, CAS No.9013-56-3

CAS: 9013-56-3 Cat. No.: np330962

GRADE & PURITY BioReagent, Native, ≥94%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Accession #

P00488,P05160

Bioactivity

See COA

Übersicht

Human Factor XIII is a tetramer composed of two pairs of chains held together by noncovalent bonds. After activation of the zymogen via Thrombin to its active enzyme form, Factor XIIIa is responsible for catalyzing the formation of covalent bridges between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is very insoluble and resistant to lysis.

Buffer composition =50 mM Tris-HCl/0.1 M NaCl/1 mM EDTA/10u/mL aprotinin/20% glycerol/pH 7.5

Extinction Coefficient (1%)=13.8

Molecular Weight = 320,000 daltons

The human factor XIII is ≥94% as judged by SDS-PAGE. One plasma equivalent unit (PEU) is equal to ~108 Loewy units. The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.

Specifications

Product Name

Factor XIII, CAS No.9013-56-3

Synonyme

Native Human Factor XIII protein | Human Factor XIII Native Protein | Coagulation Factor XIII, Human Plasma | Human Factor XIII | Fibrin Stabilizing Factor | F13A1 | F13B | F13A | FXIIIB

Note

BioReagent, Native

Spezifikationen & Reinheit

BioReagent, Native, ≥94%(SDS-PAGE), from Human plasma; Protein concentration: See COA

Biochemische und physiologische Mechanismen

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fib

Bioaktivität

See COA

Beitritt #

P00488,P05160

Voraussichtliches Molekulargewicht

320 kDa

CAS

9013-56-3

Molekültyp

Protein

Lagerung und Versand

Konzentration

from Human plasma; Protein concentration: See COA

Storage

Store at -80°C,Avoid repeated freezing and thawing

Verschickt in

Dry ice packs + Cold packs

Stabilität und Lagerung

Store at -80℃ long term. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Definition der Einheit

One plasma equivalent unit (PEU) is equal to ~108 Loewy units.