4-(4-Fluorophenyl)piperazine-1-carboxamide: Key FAQs

4-(4-Fluorophenyl)piperazine-1-carboxamide is a fluorinated piperazine-based carboxamide building block widely used in medicinal chemistry and drug discovery research as a versatile synthetic intermediate.

Product Name

4-(4-Fluorophenyl)piperazine-1-carboxamide

SKU

F1297738

Core Structure

Piperazine ring bearing a 4-fluorophenyl group at N-4 and a primary carboxamide at N-1

Primary Use

Synthetic intermediate and building block in medicinal chemistry and drug discovery

Key Functional Groups

Tertiary amine (piperazine N-4), primary carboxamide (N-1), aryl fluoride

Recommended Storage

Cool, dry, well-ventilated area away from light and incompatible materials; follow label instructions

Chemical Identity and Structure

4-(4-Fluorophenyl)piperazine-1-carboxamide (SKU: F1297738) is a synthetic organic compound built around a six-membered piperazine ring. The N-4 nitrogen of the piperazine carries a para-fluorophenyl substituent, while the N-1 nitrogen bears a primary carboxamide (–C(=O)NH₂) group. The presence of the fluorine atom on the phenyl ring is a deliberate design feature commonly exploited in medicinal chemistry: fluorine enhances metabolic stability, modulates lipophilicity, and can strengthen binding interactions through electrostatic and orthogonal effects. The carboxamide moiety at N-1 provides a handle for further derivatization, enabling chemists to construct more complex pharmacophores via acylation, coupling, or condensation reactions.

Research Applications

This compound serves primarily as a building block and synthetic intermediate in the preparation of biologically active molecules. Key application areas include:

• Medicinal chemistry: The 4-fluorophenylpiperazine motif is a well-established pharmacophore element found in numerous CNS-active agents and receptor ligands. Researchers incorporate this scaffold to probe structure–activity relationships (SAR) at piperazine-bearing drug candidates.
• Drug discovery: As a fragment or intermediate, the compound can be elaborated into libraries of analogues for high-throughput screening against enzymatic or receptor targets.
• Synthesis of receptor ligands: Fluorophenylpiperazine units are commonly employed in the design of dopamine, serotonin, and adrenergic receptor modulators, making this carboxamide a useful precursor in such programs.

Researchers should verify the specific biological activity of this exact compound independently, as the carboxamide substitution differentiates it from related N-unsubstituted or N-acyl piperazine analogues.

Handling, Storage, and Safety

As with all fine chemicals and research reagents, proper handling and storage of 4-(4-Fluorophenyl)piperazine-1-carboxamide are essential to maintain product integrity and ensure laboratory safety.

• Storage: Store in a cool, dry, well-ventilated location, protected from light and moisture. Keep the container tightly sealed when not in use. Follow all label-specific storage temperature recommendations.
• Handling: Wear appropriate personal protective equipment (PPE) including gloves, lab coat, and eye protection. Avoid inhalation of dust or aerosols. Work in a fume hood when handling bulk quantities.
• Incompatibilities: Keep away from strong oxidizing agents, strong acids, and strong bases, which are generally incompatible with secondary amine- and amide-containing compounds.
• Disposal: Dispose of according to local, regional, and national regulations applicable to organic chemical waste.

Always consult the Safety Data Sheet (SDS) provided with the product before use. Contact Aladdin Scientific for SDS requests.

Solubility and Solution Preparation

The solubility of 4-(4-Fluorophenyl)piperazine-1-carboxamide depends on the solvent system chosen. General guidance based on the compound's structural features is provided below; researchers should empirically determine solubility for their specific application:

• Polar aprotic solvents such as DMSO and DMF are generally good first-choice solvents for piperazine carboxamide compounds and are recommended for preparing stock solutions for biological assays.
• Aqueous solubility may be limited due to the lipophilic 4-fluorophenyl group; addition of co-solvents or pH adjustment may be required for aqueous formulations.
• Organic solvents such as ethanol, methanol, or DCM may dissolve the compound effectively for synthetic applications.

Recommended practice: Prepare a concentrated stock solution in DMSO, then dilute into the desired aqueous or assay buffer immediately before use. Vortex and/or warm gently to assist dissolution. Verify concentration by UV-Vis or gravimetric methods as appropriate. Note that specific solubility data should be confirmed experimentally or requested from Aladdin Scientific.

Ordering and Availability

4-(4-Fluorophenyl)piperazine-1-carboxamide is available from Aladdin Scientific under SKU F1297738. To place an order or inquire about availability, pricing, and pack sizes, please visit the Aladdin Scientific website or contact our customer service team.

• SKU: F1297738
• Supplier: Aladdin Scientific
• Quote requests: Available for bulk quantities; contact sales for custom pack sizes or purity specifications.
• Documentation: Certificate of Analysis (CoA) and Safety Data Sheet (SDS) are available upon request or downloadable from the product page.

For questions about payment, pricing, promotions, shipping, or returns, please refer to the relevant sections of the Aladdin Scientific website or contact customer support directly.

Frequently asked questions

What is 4-(4-Fluorophenyl)piperazine-1-carboxamide used for in research?

4-(4-Fluorophenyl)piperazine-1-carboxamide is primarily used as a synthetic building block and intermediate in medicinal chemistry and drug discovery. The fluorophenylpiperazine scaffold is a well-recognized pharmacophore element, and the N-1 carboxamide group allows further chemical elaboration toward more complex drug candidates or receptor ligands.

What solvent should I use to dissolve 4-(4-Fluorophenyl)piperazine-1-carboxamide?

For biological assays, DMSO is generally the recommended first-choice solvent for preparing stock solutions of piperazine carboxamide compounds. For synthetic applications, organic solvents such as DMF, ethanol, methanol, or DCM may be suitable. Aqueous solubility may be limited due to the lipophilic fluorophenyl group; empirical testing is advised, and specific solubility data can be requested from Aladdin Scientific.

How should I store F1297738 to maintain its stability?

Store 4-(4-Fluorophenyl)piperazine-1-carboxamide (F1297738) in a cool, dry, well-ventilated area, protected from light and moisture, with the container tightly sealed. Always follow the specific storage conditions stated on the product label and Safety Data Sheet. For long-term storage guidance, contact Aladdin Scientific or refer to the product CoA.

How do I obtain a Certificate of Analysis (CoA) or Safety Data Sheet (SDS) for F1297738?

The Certificate of Analysis and Safety Data Sheet for F1297738 are available upon request from Aladdin Scientific customer service or may be downloadable directly from the product page on the Aladdin Scientific website. Please have your lot number ready when requesting a CoA to ensure you receive the document specific to your batch.

Is 4-(4-Fluorophenyl)piperazine-1-carboxamide available in bulk quantities?

Yes, Aladdin Scientific can accommodate bulk quantity requests for F1297738. Please contact the sales team directly to discuss custom pack sizes, pricing, purity specifications, and lead times for larger orders.

References

1. Fluorine in Medicinal Chemistry: General Principles and Recent Advances — textbook-level reference on fluorine substituent effects in drug design. No specific publication cited; flag for editorial review.
2. Piperazine scaffold in drug discovery — general medicinal chemistry reference covering piperazine-based pharmacophores in CNS and receptor ligand design. No specific publication cited; flag for editorial review.
3. Aladdin Scientific product page for F1297738: 4-(4-Fluorophenyl)piperazine-1-carboxamide. Retrieved from Aladdin Scientific official website.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.