4-Ethylpiperazin-2-one Hydrochloride: FAQs & Lab Guide

4-Ethylpiperazin-2-one hydrochloride is a piperazinone-class heterocyclic building block widely used as a synthetic intermediate in medicinal chemistry and pharmaceutical research.

Product Name

4-Ethylpiperazin-2-one hydrochloride

Aladdin SKU

E770111

Chemical Class

Piperazin-2-one (piperazinone) derivative, hydrochloride salt

Primary Application

Synthetic intermediate and building block in medicinal and heterocyclic chemistry

Physical Form

Solid (hydrochloride salt form)

Recommended Storage

Cool, dry conditions; away from moisture and incompatible materials

What Is 4-Ethylpiperazin-2-one Hydrochloride?

4-Ethylpiperazin-2-one hydrochloride is a six-membered nitrogen-containing heterocyclic compound belonging to the piperazin-2-one (piperazinone) family. The free base features a piperazine ring with a ketone (lactam) at the 2-position and an ethyl substituent at the 4-nitrogen. It is supplied as its hydrochloride salt to improve stability and ease of handling compared with the free base form.

This compound is of interest in pharmaceutical and synthetic chemistry as a versatile scaffold. The piperazinone core is found in numerous bioactive molecules, making N-substituted derivatives such as this compound valuable building blocks for drug discovery programs and combinatorial chemistry libraries.

Solubility, Storage, and Handling

Solubility: As a hydrochloride salt, 4-Ethylpiperazin-2-one hydrochloride is expected to show good solubility in water and polar protic solvents such as methanol and ethanol. Solubility in non-polar organic solvents is expected to be limited. Users should prepare fresh stock solutions and verify solubility empirically for their specific application conditions.

Storage: Store in a tightly sealed container under cool, dry conditions, protected from moisture and light. Hydrochloride salts of lactam compounds can be hygroscopic; desiccant storage is recommended. Consult the product-specific Safety Data Sheet (SDS) for full storage and disposal requirements.

Handling: Standard laboratory precautions apply. Use appropriate personal protective equipment (PPE) including gloves, lab coat, and eye protection. Work in a well-ventilated area or fume hood when handling powders to minimize inhalation exposure.

Purity, Specifications, and Quality

Aladdin Scientific supplies 4-Ethylpiperazin-2-one hydrochloride (SKU E770111) for research use. For precise purity grade, analytical data (such as HPLC purity, NMR confirmation, and elemental analysis), and available pack sizes, researchers and procurement staff should consult the current product page on the Aladdin Scientific website or contact technical support directly.

When evaluating reagent quality for sensitive synthetic steps, consider requesting a Certificate of Analysis (CoA) for the specific lot number. The CoA documents actual measured purity and any additional quality control data generated for that batch.

Ordering, Availability, and Support

How to Order: 4-Ethylpiperazin-2-one hydrochloride is listed under SKU E770111 in the Aladdin Scientific catalog. Orders can be placed directly through the Aladdin Scientific online store, by email, or through your institution's preferred procurement channel.

Availability: Stock availability may vary. For the most current inventory status, lead times for out-of-stock items, and bulk or custom quantity inquiries, contact Aladdin Scientific customer service or your local distributor.

Technical Support: For application questions, compatibility queries, or documentation requests (SDS, CoA), Aladdin Scientific's technical support team is available to assist research and procurement staff.

Frequently asked questions

What is the CAS number for 4-Ethylpiperazin-2-one hydrochloride?

The specific CAS number for 4-Ethylpiperazin-2-one hydrochloride should be confirmed on the current Aladdin Scientific product page for SKU E770111 or the product's Certificate of Analysis, as CAS numbers differ between the free base and the hydrochloride salt forms.

In what solvents can 4-Ethylpiperazin-2-one hydrochloride be dissolved?

As a hydrochloride salt of a polar lactam, this compound is expected to dissolve well in water and polar protic solvents such as methanol and ethanol. Solubility in aprotic solvents such as DMSO may be limited and should be tested empirically. Non-polar solvents are generally unsuitable.

How should 4-Ethylpiperazin-2-one hydrochloride be stored to maintain stability?

Store the compound in a tightly sealed container at cool room temperature in a dry environment, protected from moisture and direct light. Because hydrochloride salts of lactam compounds can absorb atmospheric moisture, storage with a desiccant is advisable. Always refer to the product SDS for authoritative storage guidance.

What are the typical research applications of 4-Ethylpiperazin-2-one hydrochloride?

This compound serves primarily as a synthetic building block and intermediate in medicinal chemistry, particularly for the preparation of piperazinone-containing drug candidates and heterocyclic libraries. The piperazin-2-one scaffold is prevalent in pharmacologically active compounds, making N-substituted derivatives like this one valuable for structure-activity relationship (SAR) studies.

Is a Certificate of Analysis (CoA) available for SKU E770111?

Yes, a lot-specific Certificate of Analysis is typically available for Aladdin Scientific products. You can request the CoA for a specific lot number of E770111 through the Aladdin Scientific website or by contacting customer service, providing the lot number printed on your product label.

References

1. Aladdin Scientific product listing: 4-Ethylpiperazin-2-one hydrochloride, SKU E770111.
2. McLin (麦克林) reference: E899263 — cross-reference noted in source material; relationship to Aladdin SKU E770111 requires verification.

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.