My animal has died immediately after injection of (clodronate) liposomes。

My animal has died immediately after injection of (clodronate) liposomes。

This is most probably due to injection of non-homogenous, precipitated liposomes. The precipitated liposomes may cause an embolism and thereby a partial or total blocking of blood flow in an artery or vein. Since liposomes tend to precipitate during storage, please make sure to resuspend by gently shaking before usage.

Another reason might be the temperature of the liposomal suspension. Liposomes should be stored between 4 and 8 degrees Celsius, but they should be administered at room temperature.