Articles by tag "2-oxabicyclo[2.1.1]hexane"

1. 2-Oxabicyclo[2.1.1]hexane as a Replacement for ortho- and meta-Disubstituted Benzenes: From Geometric Matching to Functional Validation
   posted this at 15.10.2026

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   Introduction 2-Oxabicyclo[2.1.1]hexane (2-oxa-BCH) is a rigid, sp³-rich, oxygen-containing bicyclic scaffold. Based on crystallographic structures, a 2020 study proposed that 1,4-disubstituted 2-oxa-BCH could mimic meta-disubstituted benzene, although the corresponding biological activity ...