Amide bond

Decision Logic for Selecting Coupling Reagents in Amide Bond Formation: Activation Pathways, Side Reactions, Epimerization, Workup, and Safety

Amide bond formation is not as simple as merely “choosing a reagent that can activate a carboxylic acid.” Many coupling systems can connect an acid and an amine, but they do not channel the carboxylic acid through the same activation pathway, they generate different activated intermediates, ...