Drugs

Aryl C–N bonds are widely found in pharmaceuticals, agrochemicals, and functional molecules. Transition-metal-catalyzed amination reactions such as Buchwald–Hartwig amination typically employ aryl halides or pseudohalides as aryl electrophiles, whereas classical nucleophilic aromatic ...

Drug molecules bind to proteins in an aqueous environment. Before binding, polar groups on the drug surface, such as hydroxyl groups, carbonyl groups, ether oxygens, and heterocyclic nitrogens, interact with surrounding water molecules, while water molecules with different positions and ...