Granzyme A

Granzyme A and Granzyme B Signaling Pathways: Cytotoxic Effects and Immune Regulatory Mechanisms

Granzyme A (GZMA) and Granzyme B (GZMB) are serine proteases released by cytotoxic T cells, natural killer cells, and some NKT cells. They are key effector molecules in the perforin–granzyme cytotoxic system. GZMB is mainly associated with caspase-dependent apoptosis, the Bid–mitochondrial ...