Solid-Phase Peptide Synthesis

Peptides have become an important class of molecules in modern medicinal chemistry and chemical biology. Compared with traditional small molecules, peptides often offer higher target selectivity and stronger molecular recognition capability, while still retaining good structural tunability. As a ...

Solid-Phase Peptide Synthesis (SPPS) is a method in which a growing peptide chain is covalently “tethered” to insoluble resin beads, and the synthesis proceeds through repeated cycles of “deprotection → coupling one amino acid → washing.” Because the peptide remains attached to the ...