1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Stem cells are undifferentiated or poorly differentiated cells capable of self-renewal and, under specific conditions, differentiation into one or more functional cell types. With the development of regenerative medicine, induced pluripotent stem cells, organoids, and cell-engineering ...
Autophagy is an essential lysosome-dependent quality-control process through which cells degrade and recycle intracellular material. Based on how substrates enter degradative compartments, autophagy is primarily classified into macroautophagy, microautophagy, and chaperone-mediated autophagy. ...
The coumarin scaffold consists of a benzene ring fused to an α,β-unsaturated lactone ring. The C2 carbonyl group, C3=C4 double bond, and benzene ring form a continuous π-conjugated system. Upon ultraviolet irradiation, electrons can be promoted from the ground state to higher energy levels, ...
Functional peptides can perform different biological and engineering functions through sequence and structural design. Cell-penetrating peptides are primarily used to improve the cellular uptake and intracellular delivery of macromolecular and hydrophilic cargoes; targeting peptides increase ...
Mitophagy is a quality-control process that selectively recognizes and removes damaged, dysfunctional, or physiologically designated mitochondria. Its core processes include damage sensing, selective labeling, autophagic membrane sequestration, and lysosomal degradation. The PINK1–Parkin ...
Classical lignans consist of two C6–C3 units joined by a direct C8–C8′ carbon–carbon bond. On the basis of this shared linkage, different lignans vary in the oxidation states of oxygen-containing functional groups on their side chains, intramolecular C–O linkages, and additional C–C ...
Suzuki–Miyaura coupling primarily uses aryl halides or aryl pseudohalides and organoboron reagents as coupling partners, and its typical outcome is the formation of a new C–C bond. In 2024, Onnuch, Ramagonolla, and Liu reported aminative Suzuki–Miyaura coupling, in which an NH unit is ...
Lignan-related natural products share a common phenylpropanoid structural basis. However, their fundamental classification as “lignans,” “neolignans,” or “oxyneolignans” does not depend on the presence of specific structural features such as furan rings, lactone rings, or biphenyl ...
With the acceleration of population aging, age-related cancers, cardiovascular diseases, neurodegenerative diseases, and metabolic abnormalities continue to increase, making the mechanisms of aging an important direction in life science and disease research. Cellular senescence is an important ...