1,700+ technical articles by Aladdin Scientific's scientists on reagent selection, reaction mechanisms, assay design and formulation. New every week.
Poorly soluble drugs in aqueous drug-delivery systems are prone to insufficient drug-loading concentrations, crystallization during storage, and precipitation after dilution with physiological fluids. Solubilizers, hydrotropes, and cosolvents can increase drug solubility through micellar ...
Lead compound optimization usually requires the simultaneous modulation of target activity, solubility, membrane permeability, metabolic stability, and nonspecific binding. A structural change may improve one property while shifting another outside the desired range. For example, basic amines ...
Hydroquinone, also known as 1,4-dihydroxybenzene, contains two phenolic hydroxyl groups at the para positions of the benzene ring. During the formation of arbutin, one phenolic hydroxyl group forms an O-glycosidic bond with the anomeric carbon of D-glucose, while the other phenolic hydroxyl ...
Efferocytosis is the process by which phagocytes recognize, engulf, and degrade dying cells before they undergo secondary necrosis. Clearance of apoptotic cells is the most typical form of efferocytosis and involves phagocyte recruitment, phosphatidylserine recognition, phagocytic receptor ...
Coenzyme Q10 is commonly used in antioxidant and anti-aging skincare products.
“Plant collagen” in skincare products does not refer to a single substance with a completely uniform composition and structure. The term may refer to plant-derived protein peptides such as hydrolyzed soy protein and hydrolyzed wheat protein; it may also refer to recombinant collagen produced ...
Polydeoxyribonucleotide (PDRN) is a mixture of DNA fragments composed of deoxyribonucleotides linked through 3′,5′-phosphodiester bonds. PDRN is not a single compound with a fixed molecular weight. Different raw materials may vary considerably in average chain length, molecular weight ...
Depression involves multilevel abnormalities in monoaminergic transmission, the balance between glutamate and GABA, regulation of the stress axis, and synaptic plasticity. Different targets separately influence mood, reward, cognition, sleep, and stress responses and together form an ...
In skincare products, retinol generally refers to all-trans-retinol. It has the molecular formula C₂₀H₃₀O and belongs to the naturally occurring vitamin A family of compounds.