The KRAS G12C mutation is one of the common driver mutations in malignant tumors such as colorectal cancer (CRC) and non-small cell lung cancer (NSCLC). Recently approved KRAS G12C inhibitors like Adagrasib (MRTX849) and Sotorasib have provided unprecedented therapeutic options for patients.
Animal tumor models are one of the indispensable technical platforms in modern oncology research, widely used in the fields of tumor occurrence mechanism research, new drug screening, pharmacological and toxicological evaluation, immunotherapy validation, and translational medicine exploration.
At present, with the rapid development of science and technology, semiconductor materials have become a shining pearl in the field of science and technology, widely penetrating into all aspects of our lives.
In vitro cytotoxicity testing is a fundamental technique in drug screening, compound safety evaluation, biomaterial assessment, and cancer research. These assays use cells as models to evaluate the effects of test substances on cell proliferation, viability, morphology, or function. Compared to ...
Gel electrophoresis is a common laboratory technique in molecular biology to identify, quantify, and purify nucleic acids. Because of its speed, simplicity, and versatility, the method is widely employed for separation and analysis of nucleic acids. Using gel electrophoresis, nucleic acids in ...
N-Fluorobenzenesulfonimide serves as a gentle electrophilic fluorinating agent and is also capable of acting as a potent oxidant to facilitate reductive elimination processes involving transition metals.
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