Fatostatin - ≥98% , CAS No.125256-00-0

CAS: 125256-00-0 Cat. No.: F414484 Summenformel: C₁₈H₁₈N₂S Molekulargewicht: 294.41 EG-Nummer: 682-929-7

GRADE & PURITY ≥98%

Synonyms

2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole | Fatostatin;125B11 | BCP20994 | cid_2850562 | 2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobromide | 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole | 4-(4-METHYLPHENYL)-2-(2-PROPYL-4-PYRIDYL)-1,3-TH

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Information

Fatostatin Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.

Targets

SREBP

In vitro

Fatostatin impairs the activation process of sterol regulatory element binding proteins (SREBPs), thereby decreasing the transcription of lipogenic genes in cells. Fatostatin inhibits the ER-Golgi translocation of SREBPs through binding to their escort protein, the SREBP cleavage-activating protein (SCAP), at a distinct site from the sterol-binding domain.

In vivo

Fatostatin blocks increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake. Fatostatin may serve as a tool for gaining further insights into the regulation of SREBP.

Cell Research(from reference)

Cell lines：CHO-K1 cells 

Concentrations：20 μM 

Incubation Time：20 h 

Specifications

Synonyme

2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole | Fatostatin;125B11 | BCP20994 | cid_2850562 | 2-(2-propyl-4-pyridyl)-4-(p-tolyl)thiazole;hydrobromide | 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole | 4-(4-METHYLPHENYL)-2-(2-PROPYL-4-PYRIDYL)-1,3-TH

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. F

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Reinheit

≥98%

Produkteigenschaften

ALogP

4.898

hba_count

2

Rotationsfähige Bindung

4

Namen und Kennungen

Pubchem Sid

504760647

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/504760647

Kanonisches Lächeln

CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C

IUPAC Name

4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole

InChIKey

ZROSUBKIGBSZCG-UHFFFAOYSA-N

INCHI

1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3

Isomere SMILES

CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C

Molekulargewicht

294.41

Reaxy-Rn

18507978

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=18507978&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Azoles
      • Subclass Thiazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Azoles
• Subclass: Thiazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: 2,4-disubstituted thiazoles
• Alternative Parents: Toluenes Pyridines and derivatives Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Toluene - 2,4-disubstituted 1,3-thiazole - Benzenoid - Pyridine - Monocyclic benzene moiety - Heteroaromatic compound - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as 2,4-disubstituted thiazoles. These are compounds containing a thiazole ring substituted at the positions 2 and 3.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (nicht menschlich)

Mycobacterium tuberculosis (203094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 75 mg/mL (254.74 mM); Ethanol: 75 mg/mL (254.74 mM); Water: Insoluble
• DMSO (mg/ml) Maximale Löslichkeit: 75
• DMSO (mM) Maximale Löslichkeit: 254.746781698991
• Wasser (mg/ml) Maximale Löslichkeit: ＜1
• Molekulargewicht: 294.400 g/mol
• XLogP3: 4.800
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 294.119 Da
• Monoisotopic Mass: 294.119 Da
• Topological Polar Surface Area: 54.000 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 314.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1