FD-IN-1 - ≥99% , CAS No.1646682-14-5

CAS: 1646682-14-5 Cat. No.: F649632 Summenformel: C₂₃H₂₃NO₄ Molekulargewicht: 377.43

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D ( FD ) inhibitor with an IC 50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC 50 s of 7.7 and 6.5 µM, respectively.

In Vitro

FD-IN-1 (Compound 12) exhibits functional inhibition of AP activation (IC 50 =0.26 μM) in vitro in a membrane attack complex (MAC) deposition assay using 50% human whole blood (WB). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

FD-IN-1 (Compound 12) demonstrates systemic suppression of AP activation in a lipopolysaccharide-induced alternative complement pathway (AP) activation model as well as local ocular suppression in intravitreal injection-induced AP activation model in mice expressing human FD . FD-IN-1 (Compound 12) exhibits high oral bioavailability (C57BL6 mice 83%, Beagle dogs 70%) following oral administration (mice and dogs 10 mg/kg) . FD-IN-1 (Compound 12) exhibits terminal elimination half-lives (C57BL6 mice 1.6 h and Beagle dogs 3.8 h) following intravenous administration (mice and dogs 1 mg/kg) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Human FD knock-in mice Dosage: 3 and 10 mg/kg Administration: Oral gavage Result: The AP pathway was fully inhibited for up to 10 h at the 10 mg/kg dose.

Form:Solid

Specifications

Spezifikationen & Reinheit

≥99%

Biochemische und physiologische Mechanismen

FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D ( FD ) inhibitor with an IC 50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD

Storage

Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥99%

Namen und Kennungen

Molekulargewicht

377.43

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 62.5 mg/mL (165.59 mM; ultrasonic and warming and heat to 80°C)

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥99% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1646682-14-5, the molecular formula is C23H23NO4, and the molecular weight is 377.43 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.