FG-2216 - 10mM in DMSO , CAS No.223387-75-5
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SKU
F422685
HIF Modulators
Information
FG-2216 FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 . Phase 2.
Targets
PHD2 (Cell-free assay) 3.9 μM
In vitro
FG-2216 shows the ability to stabilize HIF-α to stimulate EPO secretion.
In vivo
In male rhesus macaques, FG-2216 (60 mg/kg, p.o.), induces significant and reversible Epo induction, and induces a small elevation of HbF expression.
Weitere Informationen
| CAS | 223387-75-5 |
|---|---|
| Konzentration | 10mM in DMSO |
| Synonyme | (((1-Chloro-4-hydroxyisoquinolin-3-yl)carbonyl)amino)acetic acid | 1-Chloro-N- (hydroxyformylmethyl-4-hydroxyisoquinoline-3-carboxamide | A899534 | Isoquinoline 3 | 4ie6 | SCHEMBL522744 | DB08687 | IOX3;YM311 | FG 2216 | SCHEMBL166144 | [(1-Chloro-4-hydro |
| Spezifikationen & Reinheit | 10mM in DMSO |
| Storage | Store at -80°C |
| Verschickt in | Dry ice packs + Cold packs |
| Product Description | Information FG-2216 FG-2216 is a potent, and orally active HIF prolyl 4-hydroxylase inhibitor with IC50 of 3.9 μM for PHD2 . Phase 2. Targets PHD2 (Cell-free assay) 3.9 μM In vitro FG-2216 shows the ability to stabilize HIF-α to stimulate EPO secretion. In vivo In male rhesus macaques, FG-2216 (60 mg/kg, p.o.), induces significant and reversible Epo induction, and induces a small elevation of HbF expression. |
| Pubchem Sid | 528764454 |
| Ziel | EGLN1 |
| PubChem CID | 6914666 |
| Molekulare Formel | C12H9ClN2O4 |
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