Firibastat - 10mM in Water , Aminopeptidase A inhibitor, CAS No.648927-86-0, Aminopeptidase A inhibitor

CAS: 648927-86-0 Cat. No.: F656797 Summenformel: C₈H₂₀N₂O₆S₄ Molekulargewicht: 368.51 EG-Nummer: 817-496-7 PubChem CID: 24851355

QUALITÄT & REINHEIT 10mM in Water

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor ( K i =200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats.

In Vivo

When given orally, Firibastat (0.1-30 mg/kg; p.o.) crosses the gastrointestinal and blood-brain barriers, enters the brain, and generates two active molecules of EC33 which inhibit brain APA activity, blocking brain angiotensin III formation, and decrease blood pressure for several hours in hypertensive rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Normotensive and hypertensive DOCA-salt rats Dosage: 0.1-30 mg/kg Administration: P.o. Result: Resulting in a dose-dependent decrease in mean arterial blood pressure (MABP).

Spezifikationen

Spezifikationen & Reinheit

10mM in Water

Biochemische und physiologische Mechanismen

Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor ( K i =200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III a

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Aminopeptidase A inhibitor

Produkteigenschaften

ALogP

-6.9

Namen und Kennungen

Isomere SMILES

C(CS(=O)(=O)O)[C@@H](CSSC[C@H](CCS(=O)(=O)O)N)N

Alternative CAS-Nummer

648927-86-0

PubChem CID

24851355

MeSH-Eintrag

4,4'-dithio(bis(3-aminobutyl sulfonic acid));firibastat;RB 150;RB-150;RB150;RB150 cpd

Molekulargewicht

368.51

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 648927-86-0, the molecular formula is C8H20N2O6S4, and the molecular weight is 368.51 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.