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Fluxametamide - 10mM in DMSO , CAS No.928783-29-3
AVAILABLE TO ORDER
GRADE & PURITY 10mM in DMSO
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Why this grade
10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels , with IC 50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls.
In Vitro
Fluxametamide is an antagonist of GABA- and glutamate-gated chloride channels, dose-dependently inhibits currents induced by GABA and glutamate in M. domestica GABACls and GluCls, with IC 50 values of 1.95 (1.18-3.21) nM and 225 (137-372) nM, respectively, and displays potent antagonistic activity against T. urticae GABACls with an IC 50 of 0.219 (0.127-0.381) nM. Fluxametamide inhibits GABA responses in the wild-type L. striatellus GABACls with IC 50 values of 1.40 (0.57-3.29) nM; in the A2′N mutant GABACls, the IC 50 value is 3.51 (2.17-5.69) nM. Moreover, Fluxametamide scarcely inhibits GABA (EC 50 )-induced currents in rat GABACls at 10 μM and with no inhibition on glycine (EC 50 )-induced current in human α1 GlyCls at tested concentrations. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Fluxametamide shows significant insecticidal activity with an LD 50 (LD 95 ) value of 12.9 ± 4.9 ng/fly (38.7 ± 6.3 ng/fly) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 1.95 nM ( M. domestica GABACls), 225 nM ( M. domestica GluCls)
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels , with IC 50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Action Type
ANTAGONIST
Names and Identifiers
| Isomeric SMILES | CC1=C(C=CC(=C1)C2=NOC(C2)(C3=CC(=CC(=C3)Cl)Cl)C(F)(F)F)C(=O)N/C=N\OC |
|---|---|
| PubChem CID | 135927338 |
| Molecular Weight | 474.26 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
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Look up COA →🔬 Specification Sheet
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View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
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