FPL 62064 - ≥98% , CAS No.103141-09-9

CAS: 103141-09-9 Cat. No.: F412529 Summenformel: C₁₆H₁₅N₃O Molekulargewicht: 265.31

GRADE & PURITY ≥98%

Synonyms

WKLGNFJHVJIZPK-UHFFFAOYSA-N | MFCD00877802 | S0759 | 1H-Pyrazol-3-amine, N-(4-methoxyphenyl)-1-phenyl-;1H-Pyrazol-3-amine, N-(4-methoxyphenyl)-1-phenyl- | SCHEMBL5324598 | N-(4-methoxyphenyl)-1-phenylpyrazol-3-amine | 1H-Pyrazol-3-amine, N-(4-methoxypheny

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Übersicht

Information

FPL 62064 FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has potent anti-inflammatory activity.

Targets

seminal vesicle prostaglandin synthetase (Cell-free assay); RBL-1 cytosolic 5-LOX (Cell-free assay) 3.1 μM; 3.5 μM

Specifications

Synonyme

WKLGNFJHVJIZPK-UHFFFAOYSA-N | MFCD00877802 | S0759 | 1H-Pyrazol-3-amine, N-(4-methoxyphenyl)-1-phenyl-;1H-Pyrazol-3-amine, N-(4-methoxyphenyl)-1-phenyl- | SCHEMBL5324598 | N-(4-methoxyphenyl)-1-phenylpyrazol-3-amine | 1H-Pyrazol-3-amine, N-(4-methoxypheny

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and prostaglandin synthetase (cyclooxygenase, COX) with IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and seminal vesicle prostaglandin synthetase, respectively. FPL 62064 has p

Storage

Protected from light,Store at -20°C

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Produkteigenschaften

• ALogP: 4.129
• hba_count: 2
• HBD-Zahl: 1
• Rotationsfähige Bindung: 4

Namen und Kennungen

• Pubchem Sid: 504756988
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504756988
• Kanonisches Lächeln: COC1=CC=C(C=C1)NC2=NN(C=C2)C3=CC=CC=C3
• IUPAC Name: N-(4-methoxyphenyl)-1-phenylpyrazol-3-amine
• InChIKey: WKLGNFJHVJIZPK-UHFFFAOYSA-N
• INCHI: 1S/C16H15N3O/c1-20-15-9-7-13(8-10-15)17-16-11-12-19(18-16)14-5-3-2-4-6-14/h2-12H,1H3,(H,17,18)
• Isomere SMILES: COC1=CC=C(C=C1)NC2=NN(C=C2)C3=CC=CC=C3
• Molekulargewicht: 265.31
• Reaxy-Rn: 13503711
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=13503711&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Azoles
      • Subclass Pyrazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Azoles
• Subclass: Pyrazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Phenylpyrazoles
• Alternative Parents: Methoxyanilines Phenoxy compounds Methoxybenzenes Anisoles Alkyl aryl ethers Imidolactams Heteroaromatic compounds Secondary amines Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Phenylpyrazole - Methoxyaniline - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Aniline or substituted anilines - Alkyl aryl ether - Monocyclic benzene moiety - Imidolactam - Benzenoid - Heteroaromatic compound - Ether - Azacycle - Secondary amine - Organooxygen compound - Organonitrogen compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Amine - Organic oxygen compound - Aromatic heteromonocyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as phenylpyrazoles. These are compounds containing a phenylpyrazole skeleton, which consists of a pyrazole bound to a phenyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

ABCB11 Tchem Bile salt export pump (2311 Activities)

Discover Target: ABCB11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 53 mg/mL (199.76 mM); Ethanol: 20 mg/mL (75.38 mM); Water: Insoluble
• Empfindlichkeit: Light sensitive
• DMSO (mg/ml) Maximale Löslichkeit: 53
• DMSO (mM) Maximale Löslichkeit: 199.766311107761
• Wasser (mg/ml) Maximale Löslichkeit: ＜1
• Molekulargewicht: 265.310 g/mol
• XLogP3: 3.700
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 265.122 Da
• Monoisotopic Mass: 265.122 Da
• Topological Polar Surface Area: 39.100 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 285.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Häufig gestellte Fragen

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C, protected from light. The material is light-sensitive — keep it in its original opaque or amber container.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 103141-09-9, the molecular formula is C16H15N3O, and the molecular weight is 265.31 g/mol. InChIKey WKLGNFJHVJIZPK-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.