GDC-0575 (ARRY-575) - 10mM in DMSO , CAS No.1196541-47-5

CAS: 1196541-47-5 Cat. No.: G408434 Summenformel: C₁₆H₂₀BrN₅O Molekulargewicht: 378.27

GRADE & PURITY 10mM in DMSO

Synonyms

RG7741 | Cyclopropanecarboxam​ide, N-​[4-​[(3R)​-​3-​amino-​1-​piperidinyl]​-​5-​bromo-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl]​-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

GDC-0575 (ARRY-575, RG7741) is a potent and selectiveCHK1inhibitor with an IC50 of 1.2 nM.
In vitro

GDC-0575 enhances the cytotoxicity of Cytarabine (AraC) in vitro.

In vivo

GDC-0575 is a highly-selective oral small-molecule Chk1 inhibitor that results in tumor shrinkage and growth delay in xenograft models.
Cell Data

cell lines：various cancer cell lines belonging to 4 types of cancer—breast, ovarian, prostate, and endometrial cancer—in which the PIK3CA mutation and PTEN deficiency are frequently found and in which RAS/RAF is rarely mutated

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Synonyme

RG7741 | Cyclopropanecarboxam​ide, N-​[4-​[(3R)​-​3-​amino-​1-​piperidinyl]​-​5-​bromo-​1H-​pyrrolo[2,​3-​b]​pyridin-​3-​yl]​-

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

GDC-0575 (ARRY-575, RG7741) is a potent and selective CHK1 inhibitor with an IC50 of 1.2\u2009nM.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Produkteigenschaften

ALogP

1.621

hba_count

2

HBD-Zahl

3

Rotationsfähige Bindung

3

Namen und Kennungen

Isomere SMILES

C1C[C@H](CN(C1)C2=C3C(=CNC3=NC=C2Br)NC(=O)C4CC4)N

Molekulargewicht

378.27

Reaxy-Rn

39067843

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=39067843&ln=

Chemische und physikalische Eigenschaften

• Löslichkeit: Solubility (25°C) In vitro DMSO: 7 mg/mL (28.84 mM); Ethanol: 5 mg/mL (20.6 mM); Water: Insoluble
• DMSO (mg/ml) Maximale Löslichkeit: 75
• DMSO (mM) Maximale Löslichkeit: 198.271076215402
• Wasser (mg/ml) Maximale Löslichkeit: ＜1

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1196541-47-5, the molecular formula is C16H20BrN5O, and the molecular weight is 378.27 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.