Go 6976 - Moligand™, ≥98% , Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of protein kinase C alpha;Inhibitor of protein kinase D1, CAS No.136194-77-9, Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of protein kinase C alpha;Inhibitor of protein kinase D1

CAS: 136194-77-9 Cat. No.: G276069 Summenformel: C₂₄H₁₈N₄O Molekulargewicht: 378.43

GRADE & PURITY Moligand™, ≥98%

Synonyms

GO6976 | Go-6976 | 3-(13-Methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile | Goe 6976 | 5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile | B9IQO7JZ16

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Übersicht

Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.

Specifications

Synonyme

GO6976 | Go-6976 | 3-(13-Methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile | Goe 6976 | 5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile | B9IQO7JZ16

Spezifikationen & Reinheit

Moligand™, ≥98%

Biochemische und physiologische Mechanismen

Potent, selective PKC inhibitor (IC 50 values are 2.3 and 6.2 nM at PKCα and β1, respectively). Selectively inhibits Ca 2+ -dependent PKC isoforms over Ca 2+ -independent. No inhibitory activity at PKCδ, ε or ζ. Antitumor agent. Active in vitro and in viv

Storage

Store at -20°C,Desiccated

Verschickt in

Ice chest + Ice pads

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Note

Moligand™

Aktionsart

INHIBITOR

Mechanismus der Wirkung

Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of protein kinase C alpha;Inhibitor of protein kinase D1

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥98%

Namen und Kennungen

• Pubchem Sid: 488179775
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179775
• Kanonisches Lächeln: CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
• IUPAC Name: 3-(23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-3-yl)propanenitrile
• InChIKey: VWVYILCFSYNJHF-UHFFFAOYSA-N
• INCHI: 1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
• Isomere SMILES: CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
• Molekulargewicht: 378.43
• Reaxy-Rn: 8588138
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8588138&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Klasse Indoles and derivatives
      • Subclass Carbazoles
        • Ebene5 Pyrrolocarbazoles
          • Ebene6 Indolocarbazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Klasse: Indoles and derivatives
• Subclass: Carbazoles
• Intermediate Tree Nodes: Pyrrolocarbazoles
• Direct Parent: Indolocarbazoles
• Alternative Parents: Pyrrolo[2,3-a]carbazoles Pyrroloindoles Isoindolones N-alkylindoles Indoles Benzenoids N-methylpyrroles Heteroaromatic compounds Lactams Secondary carboxylic acid amides Azacyclic compounds Nitriles Organooxygen compounds Organopnictogen compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Indolocarbazole - Pyrrolo[2,3-a]carbazole - Pyrroloindole - N-alkylindole - Isoindolone - Indole - Isoindoline - Isoindole or derivatives - N-methylpyrrole - Benzenoid - Substituted pyrrole - Heteroaromatic compound - Pyrrole - Carboxamide group - Lactam - Secondary carboxylic acid amide - Nitrile - Carbonitrile - Carboxylic acid derivative - Azacycle - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as indolocarbazoles. These are polycyclic aromatic compounds containing an indole fused to a carbazole.
• External Descriptors: organic heterohexacyclic compound - indolocarbazole

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Zugehörige Ziele (menschlich)

CDK1 Tchem Cyclin-dependent kinase 1 (1 Activities)

Discover Target: CDK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor (1 Activities)

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 (1 Activities)

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK5 Tchem Cyclin-dependent-like kinase 5 (1 Activities)

Discover Target: CDK5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 (1 Activities)

Discover Target: TYK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IRAK4 Tchem Interleukin-1 receptor-associated kinase 4 (1 Activities)

Discover Target: IRAK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 (0 Activities)

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITK Tclin Tyrosine-protein kinase ITK/TSK (1 Activities)

Discover Target: ITK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK3 Tclin Tyrosine-protein kinase JAK3 (1 Activities)

Discover Target: JAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK4 Tchem Serine/threonine-protein kinase PLK4 (2 Activities)

Discover Target: PLK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCB Tchem Protein kinase C beta type (2 Activities)

Discover Target: PRKCB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKD2 Tchem Serine/threonine-protein kinase D2 (1 Activities)

Discover Target: PRKD2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKD1 Tchem Serine/threonine-protein kinase D1 (2 Activities)

Discover Target: PRKD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK2 Tchem Serine/threonine-protein kinase MARK2 (1 Activities)

Discover Target: MARK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MARK3 Tchem MAP/microtubule affinity-regulating kinase 3 (1 Activities)

Discover Target: MARK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKB Tchem Aurora kinase B (1 Activities)

Discover Target: AURKB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta (1 Activities)

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCG Tchem Protein kinase C gamma type (1 Activities)

Discover Target: PRKCG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCA Tchem Protein kinase C alpha type (4 Activities)

Discover Target: PRKCA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RPS6KA3 Tchem Ribosomal protein S6 kinase alpha-3 (1 Activities)

Discover Target: RPS6KA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDPK1 Tchem 3-phosphoinositide-dependent protein kinase 1 (1 Activities)

Discover Target: PDPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)

Discover Target: ABL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

Discover Target: EGFR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

INSR Tclin Insulin receptor (5558 Activities)

Discover Target: INSR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

Discover Target: ERBB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDGFRB Tclin Platelet-derived growth factor receptor beta (5195 Activities)

Discover Target: PDGFRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IGF1R Tclin Insulin-like growth factor I receptor (8605 Activities)

Discover Target: IGF1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KIT Tclin Stem cell growth factor receptor (10667 Activities)

Discover Target: KIT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK2A1 Tchem Casein kinase II alpha (3512 Activities)

Discover Target: CSNK2A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DAPK3 Tchem Death-associated protein kinase 3 (2108 Activities)

Discover Target: DAPK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAPK11 Tchem MAP kinase p38 beta (2785 Activities)

Discover Target: MAPK11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)

Discover Target: LCK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAPK14 Tchem MAP kinase p38 alpha (12866 Activities)

Discover Target: MAPK14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)

Discover Target: GSK3B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKCZ Tchem Protein kinase C zeta (2414 Activities)

Discover Target: PRKCZ

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP2K6 Tchem Dual specificity mitogen-activated protein kinase kinase 6 (1284 Activities)

Discover Target: MAP2K6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MYLK Tchem Myosin light chain kinase, smooth muscle (1267 Activities)

Discover Target: MYLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1G1 Tchem Casein kinase I gamma 1 (2496 Activities)

Discover Target: CSNK1G1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FGFR2 Tclin Fibroblast growth factor receptor 2 (3405 Activities)

Discover Target: FGFR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FGFR1 Tclin Fibroblast growth factor receptor 1 (9149 Activities)

Discover Target: FGFR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

STK3 Tchem Serine/threonine-protein kinase MST2 (3069 Activities)

Discover Target: STK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSNK1D Tchem Casein kinase I delta (4546 Activities)

Discover Target: CSNK1D

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CAMK2B Tchem CaM kinase II beta (1626 Activities)

Discover Target: CAMK2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)

Discover Target: SRC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHEK2 Tchem Serine/threonine-protein kinase Chk2 (4015 Activities)

Discover Target: CHEK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PDPK1 Tchem 3-phosphoinositide dependent protein kinase-1 (3758 Activities)

Discover Target: PDPK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKT2 Tchem Serine/threonine-protein kinase AKT2 (4301 Activities)

Discover Target: AKT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKT3 Tchem Serine/threonine-protein kinase AKT3 (3157 Activities)

Discover Target: AKT3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHUK Tchem Inhibitor of nuclear factor kappa B kinase alpha subunit (3170 Activities)

Discover Target: CHUK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IKBKB Tchem Inhibitor of nuclear factor kappa B kinase beta subunit (5554 Activities)

Discover Target: IKBKB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DAPK2 Tchem Death-associated protein kinase 2 (740 Activities)

Discover Target: DAPK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AURKB Tchem Serine/threonine-protein kinase Aurora-B (6805 Activities)

Discover Target: AURKB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA4 Tchem Ribosomal protein S6 kinase alpha 4 (2104 Activities)

Discover Target: RPS6KA4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ROCK1 Tclin Rho-associated protein kinase 1 (4723 Activities)

Discover Target: ROCK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIM1 Tchem Serine/threonine-protein kinase PIM1 (9629 Activities)

Discover Target: PIM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PKN2 Tchem Protein kinase N2 (1991 Activities)

Discover Target: PKN2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CSK Tchem Tyrosine-protein kinase CSK (2395 Activities)

Discover Target: CSK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

JAK3 Tclin Tyrosine-protein kinase JAK3 (8349 Activities)

Discover Target: JAK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA5 Tchem Ribosomal protein S6 kinase alpha 5 (3355 Activities)

Discover Target: RPS6KA5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKCE Tchem Protein kinase C epsilon (1520 Activities)

Discover Target: PRKCE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKCG Tchem Protein kinase C gamma (2471 Activities)

Discover Target: PRKCG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKCI Tchem Protein kinase C iota (2821 Activities)

Discover Target: PRKCI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKD1 Tchem Protein kinase C mu (1904 Activities)

Discover Target: PRKD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAF1 Tclin Serine/threonine-protein kinase RAF (4169 Activities)

Discover Target: RAF1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SYK Tclin Tyrosine-protein kinase SYK (7372 Activities)

Discover Target: SYK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITK Tclin Tyrosine-protein kinase ITK/TSK (3699 Activities)

Discover Target: ITK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA1 Tchem Ribosomal protein S6 kinase alpha 1 (2796 Activities)

Discover Target: RPS6KA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

JAK2 Tclin Tyrosine-protein kinase JAK2 (12915 Activities)

Discover Target: JAK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RPS6KA6 Tchem Ribosomal protein S6 kinase alpha 6 (2027 Activities)

Discover Target: RPS6KA6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CAMK1 Tchem CaM kinase I alpha (1664 Activities)

Discover Target: CAMK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zugehörige Ziele (nicht menschlich)

Prkcd Protein kinase C delta (192 Activities)

Discover Target: Prkcd

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Prkcb Protein kinase C beta (2 Activities)

Discover Target: Prkcb

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fgfr4 Fibroblast growth factor receptor 4 (138 Activities)

Discover Target: Fgfr4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)

Discover Target: Fgfr3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKG1 cGMP-dependent protein kinase 1 alpha (35 Activities)

Discover Target: PRKG1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Camk2g CaM kinase II gamma (1 Activities)

Discover Target: Camk2g

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tec Tyrosine-protein kinase TEC (25 Activities)

Discover Target: Tec

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero (26788 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Splenocyte (1641 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GCN5 Histone acetyltransferase GCN5 (89 Activities)

Discover Target: GCN5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Irf1 Interferon regulatory factor 1 (3 Activities)

Discover Target: Irf1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Impa1 Inositol monophosphatase 1 (16203 Activities)

Discover Target: Impa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Löslichkeit: Soluble in DMSO to 10 mM
• Molekulargewicht: 378.400 g/mol
• XLogP3: 3.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 378.148 Da
• Monoisotopic Mass: 378.148 Da
• Topological Polar Surface Area: 62.800 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 730.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Application Protocols

Only item-specific protocols and tested applications may be listed here, and none are provided in the Product Data.

• Tested applications (e.g., biochemical assay conditions, cell-based treatment protocols, positive controls): Not specified for this item; refer to CoA/Spec Sheet.
• Recommended working concentrations, incubation times, and vehicle controls: Not specified for this item; refer to CoA/Spec Sheet.

General note: For detergent- or serum-containing media, verify solubility and adsorption behavior empirically and include appropriate vehicle controls.

Biological Roles

Context from literature (for background only; not product specifications):

• Go 6976 (Gö 6976) is widely referenced as a small-molecule tool compound used to interrogate kinase-mediated signal transduction. It is commonly described as an ATP-competitive inhibitor within the broader staurosporine/indolocarbazole or bisindolylmaleimide family.
• Typical research uses include probing serine/threonine kinase pathways in cellular and biochemical systems to evaluate pathway dependencies, feedback regulation, and phosphorylation dynamics.
• Due to its polyaromatic heterocycle framework, it can interact with kinase ATP-binding pockets; selectivity profiles and off-target activity are assay- and concentration-dependent and should be empirically validated under the user’s specific conditions.

Important notes:

• Specific target selectivity, potency values, and cellular phenotypes are not provided in the Product Data for this catalog item. Researchers should consult primary literature and the item’s CoA/Spec Sheet for any available characterization and confirm results under their experimental conditions.
• All uses are for research only; not for diagnostic, clinical, or in vivo therapeutic applications.

Buffer Applications

This product is a bioactive small molecule, not a buffering reagent. It does not define a pH buffering range or capacity.

Practical handling in buffers (general guidance):

• Prepare a concentrated DMSO stock and dilute into your assay buffer immediately before use. Maintain final DMSO below the tolerance of your system (commonly ≤0.1–0.5% v/v).
• If precipitation occurs upon dilution, add the stock slowly with vigorous mixing, warm gently to room temperature, or incorporate a small percentage of co-solvent compatible with the assay (e.g., up to 0.1–0.2% DMF or ethanol), ensuring appropriate controls.
• Filter working solutions through 0.22 μm if particulate matter is observed.

For pH buffering needs, select an appropriate buffer system (e.g., HEPES, Tris, phosphate) independent of this compound.

Green Alternatives

As a bioactive test article rather than a solvent or reagent used in bulk, “green alternatives” pertain mainly to solvent and process choices during handling and assay setup.

Greener handling strategies (general):

• Prefer aqueous assay buffers with minimal DMSO carryover (≤0.1–0.2% v/v) while maintaining solubility and activity.
• Use micro-scale workflows and miniaturized assay plates (384/1536-well) to reduce compound and solvent consumption.
• Consider solvent alternatives for cleaning and sample prep (e.g., IPA/water mixtures) rather than chlorinated solvents.

Comparison of common stock solvents for bioactives (general):

• DMSO: high solvency; biodegradable but with workplace exposure considerations; minimize volumes and ensure proper waste segregation.
• PEG-400 or aqueous cyclodextrin vehicles: can enhance apparent solubility for certain assays; evaluate biological compatibility and assay interference.
• Ethanol: more volatile and flammable; lower solvency for polyaromatics but easier to remove in analytical prep.

Waste minimization:

• Consolidate DMSO-containing waste streams and avoid unnecessary rinses with chlorinated solvents.
• Use sealed plates and low-evaporation lids to minimize solvent loss and repeat dosing.

Pharmaceutical Uses

This catalog item is designated for research use only. No pharmacopeial status, excipient function, or clinical/formulation role is provided in the Product Data.

General context (non-clinical):

• Compounds of this class are commonly used as reference standards or tool compounds in preclinical discovery research, assay development, and mechanistic studies.
• Any consideration of formulation, ADME, or in vivo dosing falls outside the scope of this listing and must not be inferred. If you require data suitable for regulated development work, request a GMP-grade or pharmacopeial alternative and associated documentation.

Item-specific note:

• No therapeutic claims are made. Not for human or veterinary use. Not for household use.

Physical Properties

Item-specific properties (from Product Data):

• Appearance: Not specified for this item; refer to CoA/Spec Sheet.
• Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.

Literature/general values and expectations (informational only; not product specifications):

• Physical state: Typically supplied as a solid research compound; frequently dissolved in DMSO to make stock solutions for biochemical assays.
• Solubility profile (literature):
  • DMSO: commonly used solvent for stock solutions due to high solvating ability for polyaromatic kinase inhibitors.
  • Aqueous buffers: often very low intrinsic solubility; may require co-solvent (DMSO) or surfactant systems for working dilutions.
  • Alcohols and DMF: moderate solubility often reported for related scaffolds.
• Partitioning: Aromatic, heterocycle-rich scaffolds generally show moderate-to-high lipophilicity (qualitative, literature-based).
• Melting point, boiling point, density, pKa, logP/logD, refractive index: Not specified for this item; consult primary literature or CoA/Spec Sheet if available.

Practical notes (general):

• Prepare concentrated DMSO stocks (e.g., 10–50 mM) and dilute into assay buffer immediately before use to minimize precipitation.
• Filter-sterilization of working solutions (0.22 μm) may help remove particulates if used in cell-based research.

Quality and Grades

• Item-specific grade: Moligand™ (as provided). While not a standardized external grade designation, this label typically indicates a screening- or library-ready small molecule intended for research use, often suitable for biochemical/cellular assay development and high-throughput screening contexts.

What this generally implies (context, not a specification):

• Emphasis on identity and usability for discovery workflows (e.g., supplied with known identifiers and compatible with DMSO stock preparation).
• May prioritize batch-to-batch consistency and dryness appropriate for accurate weighing and stock preparation.

What is not specified for this item (consult CoA/Spec Sheet):

• Exact purity assay and method, water content, residual solvents, inorganic/metal content, stabilizers, or UV-cutoff. If any of these are critical for your application (e.g., quantitative enzymology, analytical reference use), request the current CoA.

Practical quality considerations for kinase-tool compounds (general):

• Verify identity by LC–MS or HPLC-UV upon receipt if using in quantitative studies.
• For low-solubility materials, confirm apparent purity in the chosen solvent system to avoid precipitation masking impurities.

Reaction and Applications

This product is primarily used as a bioactive research tool compound rather than as a synthetic reagent.

Applications in research workflows (general, literature-based):

• Cell signaling studies: employed in pathway dissection experiments to modulate kinase activity in cells or lysates.
• Enzymology/biochemistry: used in in vitro kinase inhibition assays to establish IC50 values, probe ATP-competitive binding, or serve as a control inhibitor.
• Chemical biology: reference compound in screening panels to benchmark assay performance and target engagement metrics.
• Phenotypic assays: applied to assess downstream readouts (e.g., phosphorylation states) contingent on the targeted signaling axis.

Practical tips:

• Prepare fresh working solutions from frozen DMSO stocks immediately prior to use to minimize adsorption losses and hydrolytic degradation.
• Include a vehicle control (matching DMSO percentage) and, where applicable, a positive control inhibitor to contextualize results.
• Titrate over a broad concentration range (e.g., 0.1 nM to 10 μM) initially to capture potency window; refine based on observed activity. Verify solubility and absence of visible precipitation across the range.

Note: For any use in chemical synthesis, no specific reaction utility has been provided for this item; conventional named-reaction guidance is not applicable.

Reaction Conditions

Not a synthetic reagent; no item-specific reaction condition guidance applies.

General handling conditions for assay use (literature/practice-based):

• Stock preparation: dissolve the compound in anhydrous DMSO to prepare a concentrated stock (e.g., 10–50 mM). Mix thoroughly and confirm complete dissolution (visual inspection and, if critical, analytical verification).
• Working solutions: dilute stocks into assay buffers immediately before use, maintaining DMSO within acceptable assay limits (commonly ≤0.1–0.5% v/v). Gentle warming to room temperature and vortexing can help avoid precipitation.
• Temperature: store frozen stocks at the recommended storage temperature; perform incubations at temperatures appropriate for the biological assay (e.g., 25–37°C) and limit light exposure if photosensitivity is suspected.
• Stability: minimize repeated freeze–thaw cycles via aliquoting. Discard solutions showing precipitation, discoloration, or unexpected assay artifacts.

For chemical synthesis conditions (solvent, base, catalysts, yields): not applicable to this product.

Safety and Handling

Item-specific hazard data provided: none.

• Signal Word: Not specified for this item; refer to SDS.
• H-Statements: Not specified for this item; refer to SDS.
• GHS Classification: Not specified for this item; refer to SDS.
• Pictograms: Not specified for this item; refer to SDS.

General laboratory safety guidance (informational; defer to SDS as authoritative):

• Personal protective equipment: lab coat, safety glasses, and appropriate chemically resistant gloves (e.g., nitrile). Handle powders/solids in a fume hood to minimize dust inhalation.
• Avoid inhalation, ingestion, and skin/eye contact. Wash thoroughly after handling. Do not pipette by mouth.
• Storage incompatibilities: segregate from strong oxidizers and strong acids/bases unless compatibility is known. Keep container tightly closed to limit moisture uptake and contamination.
• Special care for bioactive small molecules: minimize exposure; prepare small aliquots to avoid repeated handling. Consider light protection if the compound is reported as photosensitive in literature (check SDS/CoA).
• First-aid overview: in case of skin contact, wash with soap and water; eye contact, rinse cautiously with water for several minutes and seek medical attention; if inhaled, move to fresh air; if swallowed, rinse mouth and seek medical advice. Always consult the SDS for specific instructions.

Disposal: Collect waste and contaminated materials as hazardous organic waste in accordance with institutional and local regulations.

Solvent Selection

Compound category: bioactive, heteroaromatic small molecule. Not a process solvent; solvent choice here refers to dissolving the analyte for assay or screening use.

General solvent guidance (literature/practice-based, not item-specific specs):

• Primary stock solvent: DMSO is the preferred vehicle for concentrated stocks (e.g., 10–50 mM) due to strong solvating power for polyaromatic kinase inhibitors.
• Secondary solvents: DMF or NMP can also solubilize similar scaffolds; however, they are less common in biological assays compared with DMSO.
• Aqueous compatibility: Working solutions are usually prepared by diluting the DMSO stock into buffered saline or cell culture media, targeting final DMSO ≤0.1–0.5% v/v where assay-tolerable.
• Co-solvent strategies: For stubborn precipitation, add stock slowly with vigorous mixing, or premix with a small percentage of ethanol or PEG-400 before aqueous dilution (verify assay compatibility).

Small comparison (general):

• DMSO: maximal solvency, widely compatible with biochemical assays; may affect cell membranes at high %.
• Ethanol: easier evaporation, but lower solvency for polyaromatics; higher volatility can complicate dose accuracy.
• Aqueous buffers: typically poor direct solubility; use only after DMSO stock preparation.

Storage and Reconstitution

Item-specific storage and shipping (from Product Data):

• Storage Conditions: Store at -20°C, Desiccated.
• Shipped In: Ice chest + Ice pads.

Item-specific stabilizers, buffer, and reconstitution medium: Not specified for this item; refer to CoA/Spec Sheet.

General reconstitution guidance for bioactive small molecules (informational; not a specification):

• Reconstitution solvent: Use anhydrous DMSO to prepare a concentrated stock (e.g., 10–50 mM). Mix thoroughly to ensure complete dissolution.
• Aliquoting: Dispense into small, single-use aliquots in solvent-resistant tubes to minimize freeze–thaw cycles and headspace moisture.
• Storage of stocks: Store aliquots at -20°C or below, protected from light and moisture. Allow to warm to room temperature before opening to reduce condensation.
• Working solution preparation: Dilute the DMSO stock into pre-warmed assay buffer or media with vigorous mixing to the desired final concentration, keeping final DMSO within assay tolerance.

Stability note: Without item-specific stability data, users should verify integrity by LC–MS/HPLC after storage and before critical experiments. Discard solutions if precipitation or degradation is observed.

Research Use Note: For research use only.

Structure and Identity

Brief overview: Go 6976 (often styled Gö 6976 in literature) is a well-known small-molecule research tool compound frequently used in kinase signaling studies. The exact molecular identifiers for this catalog item are limited in the supplied Product Data; literature descriptors are provided for general context.

• Item-specific (from Product Data):

  • SKU: G276069
  • Product Name: Go 6976
  • CAS: 136194-77-9
  • CID: 3501 (as provided)
  • InChIKey: 390556 (as provided)
  • SMILES: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Formula: Not specified for this item; refer to CoA/Spec Sheet.
  • Molecular Weight: Not specified for this item; refer to CoA/Spec Sheet.

• Literature/general structural context (for background only, not item specifications):

  • Commonly described as a staurosporine-related indolocarbazole/bisindolylmaleimide-class kinase inhibitor scaffold.
  • Structural features typically include fused indole-like aromatic systems and a maleimide-like core enabling ATP-site binding in serine/threonine kinases.
  • 2D description: polycyclic, largely planar, heteroaromatic framework with multiple ring nitrogens and a central imide functionality; no stereocenters in the prototypical scaffold.

• Stereochemistry: No item-specific stereochemical information provided; refer to CoA/Spec Sheet.

Synthetic Utility

This product is not positioned as a synthetic building block or reagent in the Product Data; it is a bioactive small-molecule tool compound. Consequently, typical synthetic utility (e.g., as a coupling partner, catalyst, or protecting group reagent) is not applicable.

General chemistry perspective (literature context):

• Indolocarbazole/bisindolylmaleimide-like scaffolds are end-products of multistep syntheses and are themselves used as standards or probes rather than as intermediates.
• If derivatization is of interest (e.g., for probe development, biotinylation, or fluorescent tagging), researchers typically begin from earlier synthetic intermediates that possess orthogonal handles; the parent inhibitor is not commonly used as a linchpin reagent due to limited functional handles and potential activity loss upon modification.

Recommendation:

• For SAR or probe synthesis, consult primary synthetic literature to identify modifiable positions and suitable protected intermediates rather than modifying the final inhibitor directly.

Target Specificity

Only item-specific data from the Product Data may be included here.

• Specific biological targets, selectivity profile, potency values, and off-targets: Not specified for this item; refer to CoA/Spec Sheet.
• Assay-validated applications, species selectivity, and mechanistic annotations: Not specified for this item; refer to CoA/Spec Sheet.