λₘₐₓ, 980nm, NanoXact, 1mg/mL in water, Carboxyl (Lipoic Acid) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Product description：
Lipoic Acid contains both a carboxyl group and a dithiol group. The dithiol group strongly binds to the metal nanoparticle surface after reduction while the carboxylic acid group is available for further chemical derivatization. The acid group also provides a highly negatively charged surface at appropriately high pH.
Carboxyl surfaces can be used to covalently bind molecules with free amines (e.g. antibodies) to the surface of the particles. An amide bond between the acid surface and the free amine is formed using EDC / NHS chemistry.
At nanoComposix we use two different molecules to provide a surface with chemically accessible carboxylic acids. One is lipoic acid and the other is the lipoic acid derivative, lipoic-dPEG12-COOH, which is similar to lipoic acid but contains a PEG spacer between the thiol and carboxylic acid functional groups.
For BioReady gold nanoparticles with diameters less than 100 nm, the lipoic-dPEG12-acid is used. For larger diameter BioReady nanoparticles (e.g. 150 nm gold nanoshells), lipoic acid is used.
Peak Wavelength(> 90% peak absorbance)：980 nm
Silica Core Diameter：200 nm ± 10 nm
Gold Shell Thickness：20 nm ± 7 nm
Hydrodynamic diameter (DLS): TEM diameter plus to 30 nm
Zeta potential: –25 to –70 mV
pH of solution: 5.0 to 7.5
Particle surface: lipoic acid
Solvent: .02 mM potassium carbonate
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Löslichkeit | Soluble in H2O at 20℃ |
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