GPR40 agonist 4 - 10mM in DMSO , CAS No.2102196-57-4

CAS: 2102196-57-4 Cat. No.: G655813 Summenformel: C₂₁H₁₇ClO₅S Molekulargewicht: 416.87 PubChem CID: 131842087

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

GPR40 agonist 4 is a potent free fatty acid receptor 1 ( FFA1/ GPR40 ) agonist with a pEC 50 of 7.54.

In Vitro

GPR40 agonist 4 tends to have a low risk of activating caspase-3/7. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Single oral administration of GPR40 agonist 4 (compound 20) robustly reduces the plasma glucose excursion and enhances insulin secretion during an oral glucose tolerance test (OGTT) in a dose-dependent manner from 1 to 10 mg/kg when GPR40 agonist 4 is dosed 60 min prior to the oral glucose challenge. The area under the curve of blood glucose (AUC 0-120min ) and blood insulin (AUC 0-120min ) reveal that the minimum effective dose of GPR40 agonist 4 is 3 mg/kg. The hyperglycemia state is also markedly improved in GPR40 agonist 4 (20 mg/kg) treated group . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:pEC 50 : 7.54 (FFA1/GPR40)

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

GPR40 agonist 4 is a potent free fatty acid receptor 1 ( FFA1/ GPR40 ) agonist with a pEC 50 of 7.54.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

AGONIST

Namen und Kennungen

Isomere SMILES

C1=CC=C(C(=C1)C2=CC=CC(=C2)COC3=CC=C(C=C3)S(=O)(=O)CC(=O)O)Cl

PubChem CID

131842087

Molekulargewicht

416.87

Zugehörige Ziele (menschlich)

FFAR1 Tchem Free fatty acid receptor 1 (1 Activities)

Discover Target: FFAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2102196-57-4, the molecular formula is C21H17ClO5S, and the molecular weight is 416.87 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.