GPR81 agonist 1 - 10mM in DMSO , CAS No.1620992-67-7

CAS: 1620992-67-7 Cat. No.: G654547 Summenformel: C₂₂H₃₀N₄O₂S₂ Molekulargewicht: 446.63 PubChem CID: 86279608

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC 50 s of 58 nM and 50 nM for human and mouse GPR81, respectively. GPR81 agonist 1 inhibits lipolysis in differentiated 3T3-L1 adipocytes. GPR81 agonist 1 suppresses lipolysis in mice without cutaneous flushing. GPR81 agonist 1 displays remarkable selectivity for GPR81 over GPR109a.

In Vitro

GPR81 agonist 1 (compound 2) (1-1000 nM) inhibits lipolysis in differentiated 3T3-L1 adipocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GPR81 agonist 1 (100 mg/kg; i.p.) suppresses lipolysis in mice without cutaneous flushing . GPR81 agonist 1 (10 mg/kg; i.p.) shows good bioavailability (71%) and C max (6.3 μM) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Nine-week-old male C57/Bl6 mice (fed and fasted mice) Dosage: 100 mg/kg Administration: I.p. Result: Reduced plasma FFA content of fed and fasted mice by approximately 50% and 35%, respectively, at 15 min postdose when intraperitoneally administered at a dose of 100 mg/kg. Animal Model: Male C57/Bl6 mice Dosage: 10 mg/kg (Pharmacokinetic Analysis) Administration: I.p.(Pharmacokinetic Analysis) Result: Showed good bioavailability (71%) and C max (6.3 μM).

Specifications

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC 50 s of 58 nM and 50 nM for human and mouse GPR81, respectively. GPR81 agonist 1 inhibits lipolysis in differentiated 3T3-L1 adipocytes. GPR81 agonist 1 suppresses lipolysis in mice w

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

Isomere SMILES

CC1CCC(CC1)C(=O)NC2=NC(=C(S2)CC(=O)N3CCN(CC3)C)C4=CC=CS4

PubChem CID

86279608

Molekulargewicht

446.63

Zugehörige Ziele (menschlich)

HCAR1 Tchem Hydroxycarboxylic acid receptor 1 (0 Activities)

Discover Target: HCAR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1620992-67-7, the molecular formula is C22H30N4O2S2, and the molecular weight is 446.63 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.