10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Argon charged,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Übersicht
GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα / REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC 50 s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hyd
In Vitro:GSK2945 dose-dependently enhances the transcriptional activity of Rev-erbα and a Bmal1 (a target gene of REV-ERBs) luciferase reporter ( EC 50 of 2.05 μM). GSK2945 (20 μM; 12 hours and 24 hours; mouse and human primary hepatocytes) treatment incre
In Vivo:GSK2945 (0-10mg/kg; intraperitoneal injection; twice every day; for 7 days; male C57BL/6 mice) treatment increases hepatic mouse cholesterol 7α-hydroxylase (Cyp7a1) level and lowers plasma cholesterol in wild-type mice. MCE has not independently con
Biological Activity:GSK2945 hydrochloride is a class of tertiary amine, and is a highly specific Rev-erbα / REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist with EC 50 s of 21.5 μM and 20.8 μM, respectively. GSK2945 hydrochloride enhances cholesterol 7α-hyd
Specifications
Spezifikationen & Reinheit
10mM in DMSO
Storage
Argon charged,Store at -80°C
Verschickt in
Dry ice packs + Cold packs
Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.
Aktionsart
ACTIVATOR
Namen und Kennungen
Molekulargewicht
457.8
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Lösungsrechner
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Bewertungen
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Häufig gestellte Fragen
How should this product be stored?
Store at ?80 °C under argon. It is supplied under an argon blanket; reseal under inert gas after each use.
How is this product shipped?
This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.
What are the CAS number, molecular formula and molecular weight?
The CAS Number is G661636(DMSO), the molecular formula is C20H19Cl3N2O2S, and the molecular weight is 457.8 g/mol.
What documentation is provided?
Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.
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