HA14-1 - 10mM in DMSO , CAS No.65673-63-4

CAS: 65673-63-4 Cat. No.: H408968 Molecular Weight: 409.23

GRADE & PURITY 10mM in DMSO

Synonyms

(R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

HA14-1 is a non-peptidic ligand of aBcl-2surface pocket withIC50of ~9 μM.
In vitro

HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS.

In vivo

HA14-1(400 nM) treatment did not have any significant effect on the growth of glioblastoma tumors in immunodeficient mice. But HA14-1 (400 nM) increases the effect of the DNA-damaging agent etoposide (2.5 mg/Kg) on glioblastoma growth in vivo.
Cell Data

cell lines：

Concentrations：~25 μM

Incubation Time：20 h

Powder Purity:

Specifications

Synonyms

(R)-ethyl 2-amino-6-bromo-4-((R)-1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

HA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Isomeric SMILES: CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N
• WGK Germany: 3
• Molecular Weight: 409.23
• Reaxy-Rn: 1405035
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1405035&ln=

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 32.5 mg/mL warmed with 50ºC Water: bath (100.16 mM); Water: Insoluble; Ethanol: Insoluble
• Refractive Index: 1.57
• Boil Point(°C): 535.1° C at 760 mmHg
• Melt Point(°C): 105-108°C